@prefix dbo: . @prefix dbr: . dbr:Drugs_controlled_by_the_UK_Misuse_of_Drugs_Act dbo:wikiPageWikiLink dbr:Alfentanil . dbr:Brifentanil dbo:wikiPageWikiLink dbr:Alfentanil . dbr:Substantia_nigra dbo:wikiPageWikiLink dbr:Alfentanil . dbr:Drug_policy_of_India dbo:wikiPageWikiLink dbr:Alfentanil . @prefix foaf: . @prefix wikipedia-en: . wikipedia-en:Alfentanil foaf:primaryTopic dbr:Alfentanil . @prefix ns4: . ns4:_Al dbo:wikiPageWikiLink dbr:Alfentanil . dbo:wikiPageWikiLink dbr:Alfentanil . dbr:Opioid dbo:wikiPageWikiLink dbr:Alfentanil . dbr:ATC_code_N01 dbo:wikiPageWikiLink dbr:Alfentanil . dbo:wikiPageWikiLink dbr:Alfentanil . dbr:Sedative dbo:wikiPageWikiLink dbr:Alfentanil . dbr:Analgesic dbo:wikiPageWikiLink dbr:Alfentanil . dbr:Janssen_Pharmaceuticals dbo:wikiPageWikiLink dbr:Alfentanil . dbr:Opium_Law dbo:wikiPageWikiLink dbr:Alfentanil . dbo:wikiPageWikiLink dbr:Alfentanil . dbr:CYP2B6 dbo:wikiPageWikiLink dbr:Alfentanil . dbr:CYP3A4 dbo:wikiPageWikiLink dbr:Alfentanil . dbr:History_of_general_anesthesia dbo:wikiPageWikiLink dbr:Alfentanil . dbr:Allodynia dbo:wikiPageWikiLink dbr:Alfentanil . dbr:Anesthetic dbo:wikiPageWikiLink dbr:Alfentanil . dbr:Grindeks dbo:wikiPageWikiLink dbr:Alfentanil . @prefix rdf: . @prefix yago: . dbr:Alfentanil rdf:type yago:Ketone114926294 , dbo:Drug , yago:Ability105616246 , yago:Message106598915 , yago:Cognition100023271 , yago:WikicatEthers , yago:Quintessence114847103 , yago:Statement106722453 , dbo:ChemicalSubstance , yago:Creativity105624700 , yago:Part113809207 . @prefix umbel-rc: . dbr:Alfentanil rdf:type umbel-rc:DrugProduct , yago:Abstraction100002137 . @prefix wikidata: . dbr:Alfentanil rdf:type wikidata:Q8386 , yago:WikicatKetones , yago:Element114840755 , yago:Invention105633385 , yago:WikicatMolecularFormulas , yago:MolecularFormula106817173 , yago:Formula106816935 . @prefix ns9: . dbr:Alfentanil rdf:type ns9:ChemicalObject , yago:WikicatBelgianInventions . @prefix owl: . dbr:Alfentanil rdf:type owl:Thing , yago:Matter100020827 , yago:OrganicCompound114727670 , yago:Material114580897 , yago:Compound114818238 , yago:Chemical114806838 , yago:Substance100019613 , yago:Communication100033020 , yago:PhysicalEntity100001930 , yago:Urea115085472 , yago:Relation100031921 , yago:WikicatUreas , yago:PsychologicalFeature100023100 . @prefix rdfs: . dbr:Alfentanil rdfs:label "Alfentanil"@sv , "\u0410\u043B\u0444\u0435\u043D\u0442\u0430\u043D\u0438\u043B"@ru , "Alfentanil"@fr , "Alfentanil"@pt , "Alfentanil"@it , "Alfentanyl"@pl , "Alfentanil"@nl , "Alfentanil"@en , "Alfentanilo"@es , "Alfentanil"@de ; rdfs:comment "Alfentanil (Handelsnamen Rapifen, Alfenta) ist ein synthetisches Opioid, das fast ausschlie\u00DFlich zur An\u00E4sthesie verwendet wird. Der Wirkstoff wurde 1978 von Janssen Pharmaceutica patentiert und wird als Hydrochlorid-Monohydrat eingesetzt. Nebenwirkungen und Wechselwirkungen sind praktisch dieselben wie beim verwandten Fentanyl. Im Vergleich zu Fentanyl weist Alfentanil einen schnelleren Wirkeintritt und eine k\u00FCrzere Wirkdauer auf. Alfentanil unterliegt der Bet\u00E4ubungsmittel-Verschreibungsverordnung."@de , "Alfentanil \u00E9 um opi\u00F3ide sint\u00E9tico de curta lat\u00EAncia e curta dura\u00E7\u00E3o. Sua utiliza\u00E7\u00E3o mais frequente se d\u00E1 em anestesias ambulatoriais como suplemento intravenoso com f\u00E1rmacos anest\u00E9sicos inalat\u00F3rios ou intravenosos, ou como componente principal de anestesia balanceada (p. ex., com \u00F3xido nitroso e um f\u00E1rmaco bloqueador neuromuscular), especialmente em cirurgia card\u00EDaca."@pt , "Alfentanil \u00E8 un potente oppioide sintetico OP3 mu-agonista di breve durata d'azione analgesica, scoperto nella Janssen Pharmaceutica nel 1976. \u00C8 utilizzato per l'anestesia in chirurgia.Si tratta di un derivato del fentanyl con circa 1/10 della sua potenza e circa 1/3 della sua durata di azione ma con una velocit\u00E0 5 volte superiore.Mentre l'alfentanil tende a provocare meno complicazioni cardiovascolari rispetto ad altri farmaci simili come il fentanyl e il remifentanil, questo farmaco tende a provocare una forte depressione respiratoria e quindi il suo impiego richiede un attento monitoraggio dei segni vitali e di respirazione. L'alfentanil \u00E8 somministrato per via parenterale (iniezione) che permette di ottenere una rapida insorgenza degli effetti e di controllare precisamente il dosaggio."@it , "Alfentanyl \u2013 organiczny zwi\u0105zek chemiczny, silny, kr\u00F3tko dzia\u0142aj\u0105cy opioidowy lek przeciwb\u00F3lowy. Pod wzgl\u0119dem chemicznym jest pochodn\u0105 piperydyny i analogiem fentanylu, od kt\u00F3rego jest kilkakrotnie (3\u20134 razy) s\u0142abszy. Dzia\u0142anie przeciwb\u00F3lowe, znieczulaj\u0105ce i uspokajaj\u0105ce pojawia si\u0119 ju\u017C po kilku minutach od podania i utrzymuje si\u0119 kilkana\u015Bcie minut, co jest zwi\u0105zane z gwa\u0142townie zachodz\u0105cymi procesami dystrybucji i redystrybucji. Efekt terapeutyczny wywo\u0142ywany jest g\u0142\u00F3wnie poprzez agonistyczne dzia\u0142anie na receptor \u03BC. Stosowany jest wy\u0142\u0105cznie w anestezjologii w celu podtrzymania znieczulenia og\u00F3lnego w czasie zabiegu operacyjnego. Dzia\u0142a przeciwb\u00F3lowo 40 razy kr\u00F3cej od morfiny. Zapewnia dobr\u0105 stabilizacj\u0119 uk\u0142adu kr\u0105\u017Cenia, nie dzia\u0142a depresyjnie na mi\u0119sie\u0144 sercowy."@pl , "\u0410\u043B\u0444\u0435\u043D\u0442\u0430\u043D\u0438\u043B \u2014 \u043C\u043E\u0449\u043D\u044B\u0439 \u0441\u0438\u043D\u0442\u0435\u0442\u0438\u0447\u0435\u0441\u043A\u0438\u0439 \u043E\u043F\u0438\u043E\u0438\u0434\u043D\u044B\u0439 \u0430\u043D\u0430\u043B\u044C\u0433\u0435\u0442\u0438\u043A \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u0433\u043E \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044F, \u0438\u0441\u043F\u043E\u043B\u044C\u0437\u0443\u0435\u043C\u044B\u0439 \u0434\u043B\u044F \u043D\u0430\u0440\u043A\u043E\u0437\u0430 \u0432 \u0445\u0438\u0440\u0443\u0440\u0433\u0438\u0438. \u0410\u043D\u0430\u043B\u043E\u0433 \u0444\u0435\u043D\u0442\u0430\u043D\u0438\u043B\u0430, \u0432 4\u201410 \u0440\u0430\u0437 \u0441\u043B\u0430\u0431\u0435\u0435 \u0438 \u0432 3 \u0440\u0430\u0437\u0430 \u043C\u0435\u043D\u0435\u0435 \u0434\u043B\u0438\u0442\u0435\u043B\u044C\u043D\u043E\u0433\u043E \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044F, \u043D\u043E \u0441 \u043D\u0430\u0441\u0442\u0443\u043F\u043B\u0435\u043D\u0438\u0435\u043C \u044D\u0444\u0444\u0435\u043A\u0442\u0430 \u0432 4 \u0440\u0430\u0437\u0430 \u0431\u044B\u0441\u0442\u0440\u0435\u0435. \u0418\u043C\u0435\u0435\u0442 \u043A\u043E\u043D\u0441\u0442\u0430\u043D\u0442\u0443 \u043A\u0438\u0441\u043B\u043E\u0442\u043D\u043E\u0441\u0442\u0438 \u043E\u043A\u043E\u043B\u043E 6,5, \u0447\u0442\u043E \u043F\u0440\u0438\u0432\u043E\u0434\u0438\u0442 \u043A \u043E\u0447\u0435\u043D\u044C \u0432\u044B\u0441\u043E\u043A\u043E\u0439 \u0434\u043E\u043B\u0435 \u043D\u0435\u0438\u043E\u043D\u0438\u0437\u0438\u0440\u043E\u0432\u0430\u043D\u043D\u044B\u0445 \u043C\u043E\u043B\u0435\u043A\u0443\u043B \u043F\u0440\u0435\u043F\u0430\u0440\u0430\u0442\u0430 \u043F\u0440\u0438 \u0444\u0438\u0437\u0438\u043E\u043B\u043E\u0433\u0438\u0447\u0435\u0441\u043A\u043E\u043C pH, \u0447\u0442\u043E \u044F\u0432\u043B\u044F\u0435\u0442\u0441\u044F \u043F\u0440\u0438\u0447\u0438\u043D\u043E\u0439 \u0431\u044B\u0441\u0442\u0440\u043E\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044F \u043F\u0440\u0435\u043F\u0430\u0440\u0430\u0442\u0430. \u0410\u043D\u0442\u0430\u0433\u043E\u043D\u0438\u0441\u0442 \u03BC-\u043E\u043F\u0438\u043E\u0438\u0434\u043D\u044B\u0445 \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u043E\u0432. \u0412\u043F\u0435\u0440\u0432\u044B\u0435 \u0441\u0438\u043D\u0442\u0435\u0437\u0438\u0440\u043E\u0432\u0430\u043D \u0432 1976 \u0433\u043E\u0434\u0443 \u0424\u0440\u0430\u043D\u0441\u043E\u043C \u042F\u043D\u0441\u0441\u0435\u043D\u0441\u043E\u043C \u0438\u0437 \u043A\u043E\u043C\u043F\u0430\u043D\u0438\u0438 ."@ru , "Alfentanil is een synthetisch opio\u00EFde met een sterke analgetische werking. Het werkt snel (na \u00E9\u00E9n minuut) maar kort (10 \u00E0 20 minuten bij eenmalige toediening), sneller en korter dan het verwante fentanyl. Het wordt bijna uitsluitend gebruikt voor intubaties tijdens anesthesie en bij kortdurende operatieve ingrepen. Alfentanil heeft over het algemeen minder cardiovasculaire bijwerkingen dan fentanyl of , maar de toediening van alfentanil kan ademdepressie veroorzaken. Observatie van de ademhaling tijdens en na de operatie is daarom nodig."@nl , "El alfentanilo es un f\u00E1rmaco analg\u00E9sico sint\u00E9tico de origen opioide, de corta duraci\u00F3n y que se usa generalmente por v\u00EDa parenteral. Es com\u00FAnmente usado como anest\u00E9sico durante la cirug\u00EDa. Es un an\u00E1logo del fentanilo, pero con s\u00F3lo un 10-20% de potencia. Comparado con otros f\u00E1rmacos de su misma clase, el alfentanilo produce menos complicaciones cardiovasculares, pero provoca mayor depresi\u00F3n respiratoria. Debido a su tiempo de vida medio m\u00E1s corto es m\u00E1s usado que otros m\u00F3rficos incluso en cirug\u00EDa de larga duraci\u00F3n, debido a su m\u00E1s r\u00E1pida eliminaci\u00F3n."@es , "Alfentanil \u00E4r en kemisk f\u00F6rening med summaformeln C21H32N6O3. \u00C4mnet anv\u00E4nds som bed\u00F6vningsmedel och tillh\u00F6r gruppen opioider. \u00C4mnet \u00E4r narkotikaklassat. i Sverige f\u00F6r \u00E4mnet \u00E4r Rapifen. Alfentanil har en mycket kort (90 - 111 minuter) och ges oftast i kontinuerlig infusion via dropp. Detta medf\u00F6r att patienten f\u00E5r mindre besv\u00E4r i uppvaket efter operationen, eftersom bland annat den andningsh\u00E4mmande effekten snabbt avtar efter att infusionen upph\u00F6r. \u00C4r mindre potent \u00E4n fentanyl men mer potent \u00E4n morfin. Biotillg\u00E4ngligheten \u00E4r 100%."@sv , "Alfentanil (R-39209, trade name Alfenta, Rapifen in Australia) is a potent but short-acting synthetic opioid analgesic drug, used for anaesthesia in surgery. It is an analogue of fentanyl with around one-fourth to one-tenth the potency, one-third the duration of action, and an onset of action four times faster than that of fentanyl. Alfentanil has a pKa of approximately 6.5, which leads to a very high proportion of the drug being uncharged at physiologic pH, a characteristic responsible for its rapid onset. It is an agonist at mu opioid receptors."@en , "L'alfentanil (Rapifen, R39209) est un analg\u00E9sique majeur alternatif \u00E0 la morphine utilis\u00E9 en anesth\u00E9sie sous forme de chlorhydrate d'alfentanil (Rapifen). Son d\u00E9lai d'action court et son \u00E9limination rapide le rendent int\u00E9ressant pour les chirurgies de courte dur\u00E9e. Il a \u00E9t\u00E9 synth\u00E9tis\u00E9 pour la premi\u00E8re fois en 1976. Compar\u00E9 au Fentanyl, qui lui est chimiquement apparent\u00E9, il exerce un effet quatre fois plus rapide et trois fois plus court, avec une puissance analg\u00E9sique 4 fois plus faible. 1 mg de Fentanyl = 4 mg d'Alfentanyl.Le pic analg\u00E9sique intervient d\u00E9j\u00E0 une minute apr\u00E8s l'injection."@fr ; foaf:depiction , . @prefix dct: . @prefix dbc: . dbr:Alfentanil dct:subject dbc:General_anesthetics , dbc:Synthetic_opioids , dbc:Tetrazoles , dbc:Mu-opioid_receptor_agonists , dbc:Ethers , dbc:Lactams , dbc:Janssen_Pharmaceutica , dbc:Piperidines , dbc:Belgian_inventions , dbc:Ureas , dbc:Fentanyl , dbc:Anilides ; dbo:abstract "L'alfentanil (Rapifen, R39209) est un analg\u00E9sique majeur alternatif \u00E0 la morphine utilis\u00E9 en anesth\u00E9sie sous forme de chlorhydrate d'alfentanil (Rapifen). Son d\u00E9lai d'action court et son \u00E9limination rapide le rendent int\u00E9ressant pour les chirurgies de courte dur\u00E9e. Il a \u00E9t\u00E9 synth\u00E9tis\u00E9 pour la premi\u00E8re fois en 1976. Compar\u00E9 au Fentanyl, qui lui est chimiquement apparent\u00E9, il exerce un effet quatre fois plus rapide et trois fois plus court, avec une puissance analg\u00E9sique 4 fois plus faible. 1 mg de Fentanyl = 4 mg d'Alfentanyl.Le pic analg\u00E9sique intervient d\u00E9j\u00E0 une minute apr\u00E8s l'injection."@fr , "\u0410\u043B\u0444\u0435\u043D\u0442\u0430\u043D\u0438\u043B \u2014 \u043C\u043E\u0449\u043D\u044B\u0439 \u0441\u0438\u043D\u0442\u0435\u0442\u0438\u0447\u0435\u0441\u043A\u0438\u0439 \u043E\u043F\u0438\u043E\u0438\u0434\u043D\u044B\u0439 \u0430\u043D\u0430\u043B\u044C\u0433\u0435\u0442\u0438\u043A \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u0433\u043E \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044F, \u0438\u0441\u043F\u043E\u043B\u044C\u0437\u0443\u0435\u043C\u044B\u0439 \u0434\u043B\u044F \u043D\u0430\u0440\u043A\u043E\u0437\u0430 \u0432 \u0445\u0438\u0440\u0443\u0440\u0433\u0438\u0438. \u0410\u043D\u0430\u043B\u043E\u0433 \u0444\u0435\u043D\u0442\u0430\u043D\u0438\u043B\u0430, \u0432 4\u201410 \u0440\u0430\u0437 \u0441\u043B\u0430\u0431\u0435\u0435 \u0438 \u0432 3 \u0440\u0430\u0437\u0430 \u043C\u0435\u043D\u0435\u0435 \u0434\u043B\u0438\u0442\u0435\u043B\u044C\u043D\u043E\u0433\u043E \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044F, \u043D\u043E \u0441 \u043D\u0430\u0441\u0442\u0443\u043F\u043B\u0435\u043D\u0438\u0435\u043C \u044D\u0444\u0444\u0435\u043A\u0442\u0430 \u0432 4 \u0440\u0430\u0437\u0430 \u0431\u044B\u0441\u0442\u0440\u0435\u0435. \u0418\u043C\u0435\u0435\u0442 \u043A\u043E\u043D\u0441\u0442\u0430\u043D\u0442\u0443 \u043A\u0438\u0441\u043B\u043E\u0442\u043D\u043E\u0441\u0442\u0438 \u043E\u043A\u043E\u043B\u043E 6,5, \u0447\u0442\u043E \u043F\u0440\u0438\u0432\u043E\u0434\u0438\u0442 \u043A \u043E\u0447\u0435\u043D\u044C \u0432\u044B\u0441\u043E\u043A\u043E\u0439 \u0434\u043E\u043B\u0435 \u043D\u0435\u0438\u043E\u043D\u0438\u0437\u0438\u0440\u043E\u0432\u0430\u043D\u043D\u044B\u0445 \u043C\u043E\u043B\u0435\u043A\u0443\u043B \u043F\u0440\u0435\u043F\u0430\u0440\u0430\u0442\u0430 \u043F\u0440\u0438 \u0444\u0438\u0437\u0438\u043E\u043B\u043E\u0433\u0438\u0447\u0435\u0441\u043A\u043E\u043C pH, \u0447\u0442\u043E \u044F\u0432\u043B\u044F\u0435\u0442\u0441\u044F \u043F\u0440\u0438\u0447\u0438\u043D\u043E\u0439 \u0431\u044B\u0441\u0442\u0440\u043E\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044F \u043F\u0440\u0435\u043F\u0430\u0440\u0430\u0442\u0430. \u0410\u043D\u0442\u0430\u0433\u043E\u043D\u0438\u0441\u0442 \u03BC-\u043E\u043F\u0438\u043E\u0438\u0434\u043D\u044B\u0445 \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u043E\u0432. \u0412\u043F\u0435\u0440\u0432\u044B\u0435 \u0441\u0438\u043D\u0442\u0435\u0437\u0438\u0440\u043E\u0432\u0430\u043D \u0432 1976 \u0433\u043E\u0434\u0443 \u0424\u0440\u0430\u043D\u0441\u043E\u043C \u042F\u043D\u0441\u0441\u0435\u043D\u0441\u043E\u043C \u0438\u0437 \u043A\u043E\u043C\u043F\u0430\u043D\u0438\u0438 ."@ru , "Alfentanil \u00E4r en kemisk f\u00F6rening med summaformeln C21H32N6O3. \u00C4mnet anv\u00E4nds som bed\u00F6vningsmedel och tillh\u00F6r gruppen opioider. \u00C4mnet \u00E4r narkotikaklassat. i Sverige f\u00F6r \u00E4mnet \u00E4r Rapifen. Alfentanil har en mycket kort (90 - 111 minuter) och ges oftast i kontinuerlig infusion via dropp. Detta medf\u00F6r att patienten f\u00E5r mindre besv\u00E4r i uppvaket efter operationen, eftersom bland annat den andningsh\u00E4mmande effekten snabbt avtar efter att infusionen upph\u00F6r. \u00C4r mindre potent \u00E4n fentanyl men mer potent \u00E4n morfin. Biotillg\u00E4ngligheten \u00E4r 100%. Substansen \u00E4r narkotikaklassad och ing\u00E5r i f\u00F6rteckning N I i 1961 \u00E5rs allm\u00E4nna narkotikakonvention, samt i f\u00F6rteckning II i Sverige."@sv , "Alfentanyl \u2013 organiczny zwi\u0105zek chemiczny, silny, kr\u00F3tko dzia\u0142aj\u0105cy opioidowy lek przeciwb\u00F3lowy. Pod wzgl\u0119dem chemicznym jest pochodn\u0105 piperydyny i analogiem fentanylu, od kt\u00F3rego jest kilkakrotnie (3\u20134 razy) s\u0142abszy. Dzia\u0142anie przeciwb\u00F3lowe, znieczulaj\u0105ce i uspokajaj\u0105ce pojawia si\u0119 ju\u017C po kilku minutach od podania i utrzymuje si\u0119 kilkana\u015Bcie minut, co jest zwi\u0105zane z gwa\u0142townie zachodz\u0105cymi procesami dystrybucji i redystrybucji. Efekt terapeutyczny wywo\u0142ywany jest g\u0142\u00F3wnie poprzez agonistyczne dzia\u0142anie na receptor \u03BC. Stosowany jest wy\u0142\u0105cznie w anestezjologii w celu podtrzymania znieczulenia og\u00F3lnego w czasie zabiegu operacyjnego. Dzia\u0142a przeciwb\u00F3lowo 40 razy kr\u00F3cej od morfiny. Zapewnia dobr\u0105 stabilizacj\u0119 uk\u0142adu kr\u0105\u017Cenia, nie dzia\u0142a depresyjnie na mi\u0119sie\u0144 sercowy."@pl , "Alfentanil \u00E9 um opi\u00F3ide sint\u00E9tico de curta lat\u00EAncia e curta dura\u00E7\u00E3o. Sua utiliza\u00E7\u00E3o mais frequente se d\u00E1 em anestesias ambulatoriais como suplemento intravenoso com f\u00E1rmacos anest\u00E9sicos inalat\u00F3rios ou intravenosos, ou como componente principal de anestesia balanceada (p. ex., com \u00F3xido nitroso e um f\u00E1rmaco bloqueador neuromuscular), especialmente em cirurgia card\u00EDaca."@pt , "Alfentanil (R-39209, trade name Alfenta, Rapifen in Australia) is a potent but short-acting synthetic opioid analgesic drug, used for anaesthesia in surgery. It is an analogue of fentanyl with around one-fourth to one-tenth the potency, one-third the duration of action, and an onset of action four times faster than that of fentanyl. Alfentanil has a pKa of approximately 6.5, which leads to a very high proportion of the drug being uncharged at physiologic pH, a characteristic responsible for its rapid onset. It is an agonist at mu opioid receptors. While alfentanil tends to cause fewer cardiovascular complications than other similar drugs such as fentanyl and remifentanil, it tends to give stronger respiratory depression and so requires careful monitoring of breathing and vital signs. Almost exclusively used by anesthesia providers during portions of a case where quick, fast-acting (though not long-lasting) pain control is needed (as, for example, during nerve blocks), alfentanil is administered by the parenteral (injected) route for fast onset and precise control of dosage. Discovered at Janssen Pharmaceutica in 1976, alfentanil is classified as a Schedule II drug in the United States. Side effects of fentanyl analogs are similar to those of fentanyl itself and include itching, nausea and potentially life-threatening respiratory depression. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear."@en , "Alfentanil (Handelsnamen Rapifen, Alfenta) ist ein synthetisches Opioid, das fast ausschlie\u00DFlich zur An\u00E4sthesie verwendet wird. Der Wirkstoff wurde 1978 von Janssen Pharmaceutica patentiert und wird als Hydrochlorid-Monohydrat eingesetzt. Nebenwirkungen und Wechselwirkungen sind praktisch dieselben wie beim verwandten Fentanyl. Im Vergleich zu Fentanyl weist Alfentanil einen schnelleren Wirkeintritt und eine k\u00FCrzere Wirkdauer auf. Alfentanil unterliegt der Bet\u00E4ubungsmittel-Verschreibungsverordnung."@de , "Alfentanil is een synthetisch opio\u00EFde met een sterke analgetische werking. Het werkt snel (na \u00E9\u00E9n minuut) maar kort (10 \u00E0 20 minuten bij eenmalige toediening), sneller en korter dan het verwante fentanyl. Het wordt bijna uitsluitend gebruikt voor intubaties tijdens anesthesie en bij kortdurende operatieve ingrepen. Alfentanil heeft over het algemeen minder cardiovasculaire bijwerkingen dan fentanyl of , maar de toediening van alfentanil kan ademdepressie veroorzaken. Observatie van de ademhaling tijdens en na de operatie is daarom nodig. Alfentanil werd ontwikkeld door Janssen Pharmaceutica. Het wordt verkocht onder de merknaam Rapifen door Janssen-Cilag, in ampullen van 2 of 10 milliliter voor injectie. De injectievloeistof bevat 0,5 milligram per milliliter alfentanil als hydrochloride. In de Verenigde Staten is de merknaam Alfenta."@nl , "El alfentanilo es un f\u00E1rmaco analg\u00E9sico sint\u00E9tico de origen opioide, de corta duraci\u00F3n y que se usa generalmente por v\u00EDa parenteral. Es com\u00FAnmente usado como anest\u00E9sico durante la cirug\u00EDa. Es un an\u00E1logo del fentanilo, pero con s\u00F3lo un 10-20% de potencia. Comparado con otros f\u00E1rmacos de su misma clase, el alfentanilo produce menos complicaciones cardiovasculares, pero provoca mayor depresi\u00F3n respiratoria. Debido a su tiempo de vida medio m\u00E1s corto es m\u00E1s usado que otros m\u00F3rficos incluso en cirug\u00EDa de larga duraci\u00F3n, debido a su m\u00E1s r\u00E1pida eliminaci\u00F3n. El alfentanilo fue desarrollado por Janssen Pharmaceutica en 1976. \n* Datos: Q176533 \n* Multimedia: Alfentanil / Q176533"@es , "Alfentanil \u00E8 un potente oppioide sintetico OP3 mu-agonista di breve durata d'azione analgesica, scoperto nella Janssen Pharmaceutica nel 1976. \u00C8 utilizzato per l'anestesia in chirurgia.Si tratta di un derivato del fentanyl con circa 1/10 della sua potenza e circa 1/3 della sua durata di azione ma con una velocit\u00E0 5 volte superiore.Mentre l'alfentanil tende a provocare meno complicazioni cardiovascolari rispetto ad altri farmaci simili come il fentanyl e il remifentanil, questo farmaco tende a provocare una forte depressione respiratoria e quindi il suo impiego richiede un attento monitoraggio dei segni vitali e di respirazione. L'alfentanil \u00E8 somministrato per via parenterale (iniezione) che permette di ottenere una rapida insorgenza degli effetti e di controllare precisamente il dosaggio."@it ; dbo:wikiPageWikiLink dbr:Remifentanil , dbr:Analgesic , dbc:Lactams , dbc:Ethers , dbr:Fentanyl , dbr:Cardiovascular , dbr:Liver , dbr:Anaesthesia , dbc:Belgian_inventions , dbr:Respiratory_depression , dbr:Medication , dbr:Nausea , dbr:Itching , dbc:Piperidines , dbr:Surgery . @prefix ns14: . dbr:Alfentanil dbo:wikiPageWikiLink ns14:parenteral , dbc:Fentanyl , dbr:Mu_opioid_receptor , dbc:Mu-opioid_receptor_agonists , dbr:Janssen_Pharmaceutica , dbc:Synthetic_opioids , dbc:General_anesthetics , dbr:Intravenous_therapy , dbr:Subcut , dbr:Nerve_block , dbc:Tetrazoles , dbc:Anilides , dbc:Ureas , dbc:Janssen_Pharmaceutica , dbr:Controlled_Substances_Act , dbr:Opioid . @prefix dbp: . @prefix dbt: . dbr:Alfentanil dbp:wikiPageUsesTemplate dbt:Opioidergics , dbt:Short_description , dbt:Ebicite , dbt:Analgesics , dbt:Cascite , dbt:Chemspidercite , dbt:Reflist , dbt:Drugbankcite , dbt:Stdinchicite , dbt:Keggcite , , dbt:Drugbox , dbt:Fdacite , dbt:General_anesthetics ; dbo:thumbnail ; dbo:wikiPageRevisionID 1106912231 ; dbo:wikiPageExternalLink , , . @prefix xsd: . dbr:Alfentanil dbo:wikiPageLength "5672"^^xsd:nonNegativeInteger ; dbo:wikiPageID 1035337 . @prefix dbpedia-pl: . dbr:Alfentanil owl:sameAs dbpedia-pl:Alfentanyl . @prefix dbpedia-sr: . dbr:Alfentanil owl:sameAs dbpedia-sr:Alfentanil . @prefix dbpedia-fr: . dbr:Alfentanil owl:sameAs dbpedia-fr:Alfentanil . @prefix dbpedia-es: . dbr:Alfentanil owl:sameAs dbpedia-es:Alfentanilo . @prefix dbpedia-de: . dbr:Alfentanil owl:sameAs dbpedia-de:Alfentanil . @prefix yago-res: . dbr:Alfentanil owl:sameAs yago-res:Alfentanil . @prefix dbpedia-pt: . dbr:Alfentanil owl:sameAs dbpedia-pt:Alfentanil . @prefix dbpedia-fi: . dbr:Alfentanil owl:sameAs dbpedia-fi:Alfentaniili . @prefix dbpedia-sv: . dbr:Alfentanil owl:sameAs dbpedia-sv:Alfentanil . @prefix ns27: . dbr:Alfentanil owl:sameAs ns27:DB00802 . @prefix dbpedia-nl: . dbr:Alfentanil owl:sameAs dbpedia-nl:Alfentanil . @prefix dbpedia-it: . dbr:Alfentanil owl:sameAs dbpedia-it:Alfentanil . @prefix dbpedia-sh: . dbr:Alfentanil owl:sameAs dbpedia-sh:Alfentanil , . @prefix dbpedia-ro: . dbr:Alfentanil owl:sameAs dbpedia-ro:Alfentanil . @prefix dbpedia-da: . dbr:Alfentanil owl:sameAs dbpedia-da:Alfentanil , . @prefix dbpedia-la: . dbr:Alfentanil owl:sameAs dbpedia-la:Alfentanilum . @prefix ns34: . dbr:Alfentanil owl:sameAs ns34:hycS , wikidata:Q176533 , , dbr:Alfentanil , , ; dbp:meltingPoint "140.8"^^xsd:double . @prefix prov: . dbr:Alfentanil prov:wasDerivedFrom ; foaf:isPrimaryTopicOf wikipedia-en:Alfentanil ; dbp:chembl 634 ; dbo:chEMBL "634" ; dbp:atcSuffix "AH02"@en ; dbo:alternativeName "Alfenta"@en ; dbp:n 6 ; dbp:chemspiderid 46451 ; dbp:c 21 ; dbp:verifiedrevid 477317188 ; dbp:h 32 ; dbo:pubchem "51263" ; dbp:routesOfAdministration "Intravenous; Subcutaneous"@en ; dbp:o 3 ; dbp:pubchem 51263 ; dbp:stdinchikey "IDBPHNDTYPBSNI-UHFFFAOYSA-N"@en ; dbp:smiles "O=C1NCCN3CCCCOC"@en ; dbo:fdaUniiCode "1N74HM2BS7" ; dbp:legalUk "Class A"@en ; dbp:legalCa "Schedule I"@en ; dbp:iupacName "N-{1-[2-ethyl]-4-piperidin-4-yl}-N-phenylpropanamide"@en ; dbp:unii 1 ; dbp:casNumber 71195 ; dbp:atcPrefix "N01"@en ; dbp:stdinchi 1 ; dbp:legalDe "Anlage III"@en ; dbo:casNumber "71195-58-9" ; dbp:medlineplus "a601130"@en ; dbo:medlinePlus "a601130" . @prefix dbd: . dbr:Alfentanil dbp:durationOfAction "900.0"^^dbd:second ; dbo:chEBI "2569" ; dbp:chebi 2569 ; dbp:iupharLigand 7108 ; dbp:legalAu "S8"@en ; dbp:proteinBound "92.0"^^dbd:perCent ; dbp:width 220 ; dbp:legalUs "Schedule II"@en ; dbp:image "Alfentanil 3D BS.png"@en ; dbo:kegg "D07122" ; dbp:eliminationHalfLife "-6660.0"^^dbd:second ; dbo:drugbank "DB00802" ; dbp:drugbank "DB00802"@en ; dbp:tradename "Alfenta"@en ; dbp:bioavailability "~50%"@en ; dbp:metabolism dbr:Liver ; dbp:kegg "D07122"@en . dbr:Remifentanil dbo:wikiPageWikiLink dbr:Alfentanil . dbr:Alfentanyl dbo:wikiPageWikiLink dbr:Alfentanil ; dbo:wikiPageRedirects dbr:Alfentanil . dbr:Single_Convention_on_Narcotic_Drugs dbo:wikiPageWikiLink dbr:Alfentanil . dbr:Misuse_of_Drugs_Act_1977 dbo:wikiPageWikiLink dbr:Alfentanil . dbo:wikiPageWikiLink dbr:Alfentanil . dbr:Fentanyl dbo:wikiPageWikiLink dbr:Alfentanil . dbo:wikiPageWikiLink dbr:Alfentanil . dbo:wikiPageWikiLink dbr:Alfentanil . dbr:List_of_fentanyl_analogues dbo:wikiPageWikiLink dbr:Alfentanil . dbr:List_of_opioids dbo:wikiPageWikiLink dbr:Alfentanil . dbr:C21H32N6O3 dbo:wikiPageWikiLink dbr:Alfentanil ; dbo:wikiPageRedirects dbr:Alfentanil . dbr:Controlled_Drugs_and_Substances_Act dbo:wikiPageWikiLink dbr:Alfentanil . dbr:Mirfentanil dbo:wikiPageWikiLink dbr:Alfentanil . dbr:Trefentanil dbo:wikiPageWikiLink dbr:Alfentanil . dbr:Alfenta dbo:wikiPageWikiLink dbr:Alfentanil ; dbo:wikiPageRedirects dbr:Alfentanil . dbr:ATC_code_N01AH02 dbo:wikiPageWikiLink dbr:Alfentanil ; dbo:wikiPageRedirects dbr:Alfentanil . dbr:ATCvet_code_QN01AH02 dbo:wikiPageWikiLink dbr:Alfentanil ; dbo:wikiPageRedirects dbr:Alfentanil . dbr:Rapifen dbo:wikiPageWikiLink dbr:Alfentanil ; dbo:wikiPageRedirects dbr:Alfentanil . dbr:Alfentamil dbo:wikiPageWikiLink dbr:Alfentanil ; dbo:wikiPageRedirects dbr:Alfentanil . dbr:Alfentanil_Hydrochloride dbo:wikiPageWikiLink dbr:Alfentanil ; dbo:wikiPageRedirects dbr:Alfentanil . dbr:Alfentanil_hydrochloride dbo:wikiPageWikiLink dbr:Alfentanil ; dbo:wikiPageRedirects dbr:Alfentanil . dbr:Alfentanile dbo:wikiPageWikiLink dbr:Alfentanil ; dbo:wikiPageRedirects dbr:Alfentanil .
  NODES