@prefix dbo: . @prefix dbr: . dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . @prefix foaf: . @prefix wikipedia-en: . wikipedia-en:Arrestin_beta_2 foaf:primaryTopic dbr:Arrestin_beta_2 . dbr:Mdm2 dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:AP2B1 dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . @prefix rdf: . @prefix yago: . dbr:Arrestin_beta_2 rdf:type yago:PhysicalEntity100001930 , yago:WikicatHumanProteins , yago:Molecule114682133 , yago:Unit109465459 , yago:Macromolecule114944888 , yago:Matter100020827 , dbo:Protein , yago:Protein114728724 , yago:OrganicCompound114727670 , yago:Material114580897 , dbo:HumanGene , dbo:Biomolecule , dbo:Gene , yago:Abstraction100002137 . @prefix wikidata: . dbr:Arrestin_beta_2 rdf:type wikidata:Q7187 . @prefix umbel-rc: . dbr:Arrestin_beta_2 rdf:type umbel-rc:ProteinMolecule . @prefix owl: . dbr:Arrestin_beta_2 rdf:type owl:Thing , wikidata:Q206229 , yago:Relation100031921 , yago:Compound114818238 , yago:Chemical114806838 , yago:Substance100019613 , yago:Thing100002452 , yago:Part113809207 . @prefix rdfs: . dbr:Arrestin_beta_2 rdfs:label "Arrestin beta 2"@en , "ARRB2"@uk , "Arrestina beta 2"@es ; rdfs:comment "Beta-arrestin-2, also known as arrestin beta-2, is an intracellular protein that in humans is encoded by the ARRB2 gene. Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals, as well as having signalling roles in their own right. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific dese"@en , "La arrestina beta 2 (ARRB2) es una prote\u00EDna intracelular codificada en humanos por el gen arrb2. Los miembros de la familia de prote\u00EDnas de las parecen participar en la desensibilizaci\u00F3n mediada por agonista de los receptores acoplados a prote\u00EDnas G, causando un apagamiento espec\u00EDfico de la respuesta celular a est\u00EDmulos como hormonas, neurotransmisores o se\u00F1ales sensoriales,\u200B\u200B\u200B adem\u00E1s de actuar con diferentes papeles en la se\u00F1alizaci\u00F3n celular.\u200B\u200B\u200B\u200B\u200B La arrestina beta 2, al igual que la arrestina beta 1, fue identificada al demostrar su capacidad para inhibir la funci\u00F3n de los receptores beta adren\u00E9rgicos en ensayos in vitro. Presenta elevados niveles de expresi\u00F3n en el sistema nervioso central y puede desempe\u00F1ar un papel en la regulaci\u00F3n de los receptores sin\u00E1pticos. Adem\u00E1s del cerebro, s"@es , "ARRB2 (\u0430\u043D\u0433\u043B. Arrestin beta 2) \u2013 \u0431\u0456\u043B\u043E\u043A, \u044F\u043A\u0438\u0439 \u043A\u043E\u0434\u0443\u0454\u0442\u044C\u0441\u044F \u043E\u0434\u043D\u043E\u0439\u043C\u0435\u043D\u043D\u0438\u043C \u0433\u0435\u043D\u043E\u043C, \u0440\u043E\u0437\u0442\u0430\u0448\u043E\u0432\u0430\u043D\u0438\u043C \u0443 \u043B\u044E\u0434\u0435\u0439 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C\u0443 \u043F\u043B\u0435\u0447\u0456 17-\u0457 \u0445\u0440\u043E\u043C\u043E\u0441\u043E\u043C\u0438. \u0414\u043E\u0432\u0436\u0438\u043D\u0430 \u043F\u043E\u043B\u0456\u043F\u0435\u043F\u0442\u0438\u0434\u043D\u043E\u0433\u043E \u043B\u0430\u043D\u0446\u044E\u0433\u0430 \u0431\u0456\u043B\u043A\u0430 \u0441\u0442\u0430\u043D\u043E\u0432\u0438\u0442\u044C 409 \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u0430 \u043C\u0430\u0441\u0430 \u2014 46 106. \u041F\u043E\u0441\u043B\u0456\u0434\u043E\u0432\u043D\u0456\u0441\u0442\u044C \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442 A: \u0410\u043B\u0430\u043D\u0456\u043DC: \u0426\u0438\u0441\u0442\u0435\u0457\u043DD: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430E: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430F: \u0424\u0435\u043D\u0456\u043B\u0430\u043B\u0430\u043D\u0456\u043DG: \u0413\u043B\u0456\u0446\u0438\u043DH: \u0413\u0456\u0441\u0442\u0438\u0434\u0438\u043DI: \u0406\u0437\u043E\u043B\u0435\u0439\u0446\u0438\u043DK: \u041B\u0456\u0437\u0438\u043DL: \u041B\u0435\u0439\u0446\u0438\u043DM: \u041C\u0435\u0442\u0456\u043E\u043D\u0456\u043DN: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043DP: \u041F\u0440\u043E\u043B\u0456\u043DQ: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043DR: \u0410\u0440\u0433\u0456\u043D\u0456\u043DS: \u0421\u0435\u0440\u0438\u043DT: \u0422\u0440\u0435\u043E\u043D\u0456\u043DV: \u0412\u0430\u043B\u0456\u043D Y: \u0422\u0438\u0440\u043E\u0437\u0438\u043D"@uk . @prefix dcterms: . @prefix dbc: . dbr:Arrestin_beta_2 dcterms:subject dbc:Human_proteins , dbc:Genes ; dbo:abstract "ARRB2 (\u0430\u043D\u0433\u043B. Arrestin beta 2) \u2013 \u0431\u0456\u043B\u043E\u043A, \u044F\u043A\u0438\u0439 \u043A\u043E\u0434\u0443\u0454\u0442\u044C\u0441\u044F \u043E\u0434\u043D\u043E\u0439\u043C\u0435\u043D\u043D\u0438\u043C \u0433\u0435\u043D\u043E\u043C, \u0440\u043E\u0437\u0442\u0430\u0448\u043E\u0432\u0430\u043D\u0438\u043C \u0443 \u043B\u044E\u0434\u0435\u0439 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C\u0443 \u043F\u043B\u0435\u0447\u0456 17-\u0457 \u0445\u0440\u043E\u043C\u043E\u0441\u043E\u043C\u0438. \u0414\u043E\u0432\u0436\u0438\u043D\u0430 \u043F\u043E\u043B\u0456\u043F\u0435\u043F\u0442\u0438\u0434\u043D\u043E\u0433\u043E \u043B\u0430\u043D\u0446\u044E\u0433\u0430 \u0431\u0456\u043B\u043A\u0430 \u0441\u0442\u0430\u043D\u043E\u0432\u0438\u0442\u044C 409 \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u0430 \u043C\u0430\u0441\u0430 \u2014 46 106. \u041F\u043E\u0441\u043B\u0456\u0434\u043E\u0432\u043D\u0456\u0441\u0442\u044C \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442 A: \u0410\u043B\u0430\u043D\u0456\u043DC: \u0426\u0438\u0441\u0442\u0435\u0457\u043DD: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430E: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430F: \u0424\u0435\u043D\u0456\u043B\u0430\u043B\u0430\u043D\u0456\u043DG: \u0413\u043B\u0456\u0446\u0438\u043DH: \u0413\u0456\u0441\u0442\u0438\u0434\u0438\u043DI: \u0406\u0437\u043E\u043B\u0435\u0439\u0446\u0438\u043DK: \u041B\u0456\u0437\u0438\u043DL: \u041B\u0435\u0439\u0446\u0438\u043DM: \u041C\u0435\u0442\u0456\u043E\u043D\u0456\u043DN: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043DP: \u041F\u0440\u043E\u043B\u0456\u043DQ: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043DR: \u0410\u0440\u0433\u0456\u043D\u0456\u043DS: \u0421\u0435\u0440\u0438\u043DT: \u0422\u0440\u0435\u043E\u043D\u0456\u043DV: \u0412\u0430\u043B\u0456\u043D Y: \u0422\u0438\u0440\u043E\u0437\u0438\u043D \u041A\u043E\u0434\u043E\u0432\u0430\u043D\u0438\u0439 \u0433\u0435\u043D\u043E\u043C \u0431\u0456\u043B\u043E\u043A \u0437\u0430 \u0444\u0443\u043D\u043A\u0446\u0456\u044F\u043C\u0438 \u043D\u0430\u043B\u0435\u0436\u0438\u0442\u044C \u0434\u043E \u0444\u043E\u0441\u0444\u043E\u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0456\u0432, \u0456\u043D\u0433\u0456\u0431\u0456\u0442\u043E\u0440\u0456\u0432 \u043F\u0435\u0440\u0435\u0434\u0430\u0447\u0456 \u0432\u043D\u0443\u0442\u0440\u0456\u0448\u043D\u044C\u043E\u043A\u043B\u0456\u0442\u0438\u043D\u043D\u0438\u0445 \u0441\u0438\u0433\u043D\u0430\u043B\u0456\u0432. \u0417\u0430\u0434\u0456\u044F\u043D\u0438\u0439 \u0443 \u0442\u0430\u043A\u0438\u0445 \u0431\u0456\u043E\u043B\u043E\u0433\u0456\u0447\u043D\u0438\u0445 \u043F\u0440\u043E\u0446\u0435\u0441\u0430\u0445, \u044F\u043A \u0442\u0440\u0430\u043D\u0441\u043F\u043E\u0440\u0442, \u0442\u0440\u0430\u043D\u0441\u043F\u043E\u0440\u0442 \u0431\u0456\u043B\u043A\u0456\u0432, \u0430\u043B\u044C\u0442\u0435\u0440\u043D\u0430\u0442\u0438\u0432\u043D\u0438\u0439 \u0441\u043F\u043B\u0430\u0439\u0441\u0438\u043D\u0433. \u041B\u043E\u043A\u0430\u043B\u0456\u0437\u043E\u0432\u0430\u043D\u0438\u0439 \u0443 \u043A\u043B\u0456\u0442\u0438\u043D\u043D\u0456\u0439 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u0456, \u0446\u0438\u0442\u043E\u043F\u043B\u0430\u0437\u043C\u0456, \u044F\u0434\u0440\u0456, \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u0456, \u043A\u043B\u0430\u0442\u0440\u0438\u043D-\u0432\u043A\u0440\u0438\u0442\u0438\u0445 \u0437\u0430\u0433\u043B\u0438\u0431\u0438\u043D\u0430\u0445 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u0438, \u0446\u0438\u0442\u043E\u043F\u043B\u0430\u0437\u043C\u0430\u0442\u0438\u0447\u043D\u0438\u0445 \u0432\u0435\u0437\u0438\u043A\u0443\u043B\u0430\u0445."@uk , "La arrestina beta 2 (ARRB2) es una prote\u00EDna intracelular codificada en humanos por el gen arrb2. Los miembros de la familia de prote\u00EDnas de las parecen participar en la desensibilizaci\u00F3n mediada por agonista de los receptores acoplados a prote\u00EDnas G, causando un apagamiento espec\u00EDfico de la respuesta celular a est\u00EDmulos como hormonas, neurotransmisores o se\u00F1ales sensoriales,\u200B\u200B\u200B adem\u00E1s de actuar con diferentes papeles en la se\u00F1alizaci\u00F3n celular.\u200B\u200B\u200B\u200B\u200B La arrestina beta 2, al igual que la arrestina beta 1, fue identificada al demostrar su capacidad para inhibir la funci\u00F3n de los receptores beta adren\u00E9rgicos en ensayos in vitro. Presenta elevados niveles de expresi\u00F3n en el sistema nervioso central y puede desempe\u00F1ar un papel en la regulaci\u00F3n de los receptores sin\u00E1pticos. Adem\u00E1s del cerebro, se ha podido aislar ADNc de la arrestina beta 2 en la gl\u00E1ndula tiroidea, por lo que podr\u00EDa tambi\u00E9n estar implicada en la desensibilizaci\u00F3n espec\u00EDfica de hormona de los . Se han descrito diversas variantes transcripcionales de este gen, pero algunas de ellas a\u00FAn no han sido bien caracterizadas.\u200B La arrestina beta 2 podr\u00EDa interaccionar con el agonista en la se\u00F1alizaci\u00F3n del receptor 5-HT2A.\u200B\u200B"@es , "Beta-arrestin-2, also known as arrestin beta-2, is an intracellular protein that in humans is encoded by the ARRB2 gene. Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals, as well as having signalling roles in their own right. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. The protein may interact with the agonist DOI in 5-HT2A receptor signaling. Arrestin beta 2 is crucial for the development of tolerance to morphine and other opioids."@en ; dbo:wikiPageWikiLink dbr:RALGDS , , dbc:Genes , dbr:Protein , dbr:Protein-protein_interaction , dbr:Gene , , dbr:PSCD2 , dbr:Beta-adrenergic_receptor , dbr:Thyroid_gland , dbr:Drug_tolerance , dbr:AP2B1 , dbr:Arrestin , dbr:Alternatively_spliced , dbr:G_protein-coupled_receptor , dbr:TSH_receptor , dbc:Human_proteins , dbr:Mdm2 , dbr:CDNA , dbr:Opioid , dbr:Morphine , dbr:Arrestin_beta_1 . @prefix dbp: . @prefix dbt: . dbr:Arrestin_beta_2 dbp:wikiPageUsesTemplate dbt:Reflist , dbt:UCSC_gene_info , dbt:Infobox_gene , dbt:NLM_content , dbt:Cite_journal , dbt:Refbegin , dbt:Membrane_proteins , dbt:Refend , dbt:Short_description ; dbo:wikiPageRevisionID 1115895011 . @prefix xsd: . dbr:Arrestin_beta_2 dbo:wikiPageLength "16825"^^xsd:nonNegativeInteger ; dbo:wikiPageID 14415818 . @prefix dbpedia-sr: . dbr:Arrestin_beta_2 owl:sameAs dbpedia-sr:Arestin_beta_2 , dbr:Arrestin_beta_2 . @prefix dbpedia-sh: . dbr:Arrestin_beta_2 owl:sameAs dbpedia-sh:Arestin_beta_2 . @prefix ns17: . dbr:Arrestin_beta_2 owl:sameAs ns17:iz16 , wikidata:Q17832094 , . @prefix yago-res: . dbr:Arrestin_beta_2 owl:sameAs yago-res:Arrestin_beta_2 . @prefix dbpedia-uk: . dbr:Arrestin_beta_2 owl:sameAs dbpedia-uk:ARRB2 . @prefix dbpedia-es: . dbr:Arrestin_beta_2 owl:sameAs dbpedia-es:Arrestina_beta_2 . @prefix ns21: . dbr:Arrestin_beta_2 owl:sameAs ns21:ARRB2 . @prefix gold: . dbr:Arrestin_beta_2 gold:hypernym dbr:Protein . @prefix prov: . dbr:Arrestin_beta_2 prov:wasDerivedFrom ; foaf:isPrimaryTopicOf wikipedia-en:Arrestin_beta_2 . dbr:CYTH2 dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:RALGDS dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:RAC3 dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:RB-64 dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:Arrestin dbo:wikiPageWikiLink dbr:Arrestin_beta_2 ; dbp:name dbr:Arrestin_beta_2 ; dbp:symbol dbr:Arrestin_beta_2 . dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:Pamoic_acid dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:Cannabichromene dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:Oliceridine dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:PZM21 dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:FFAR2-FFAR3_receptor_heteromer dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:Cannabinoid_receptor_type_1 dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:Mitragynine dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:Dopamine_receptor dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:MAPK10 dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:NDUFS7 dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:SHR9352 dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:SR-17018 dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbr:TRV734 dbo:wikiPageWikiLink dbr:Arrestin_beta_2 . dbo:wikiPageWikiLink dbr:Arrestin_beta_2 ; dbo:wikiPageRedirects dbr:Arrestin_beta_2 . dbo:wikiPageWikiLink dbr:Arrestin_beta_2 ; dbo:wikiPageRedirects dbr:Arrestin_beta_2 . dbr:ARRB2 dbo:wikiPageWikiLink dbr:Arrestin_beta_2 ; dbo:wikiPageRedirects dbr:Arrestin_beta_2 . dbr:Beta-arrestin-2 dbo:wikiPageWikiLink dbr:Arrestin_beta_2 ; dbo:wikiPageRedirects dbr:Arrestin_beta_2 . dbr:Beta-arrestin_2 dbo:wikiPageWikiLink dbr:Arrestin_beta_2 ; dbo:wikiPageRedirects dbr:Arrestin_beta_2 . dbo:wikiPageWikiLink dbr:Arrestin_beta_2 ; dbo:wikiPageRedirects dbr:Arrestin_beta_2 .
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