The 2021 Melon Music Awards, organized by Kakao M and Melon, took place on December 4, 2021. This was the thirteenth ceremony in the show's history, and the second to be held without an audience in light of the COVID-19 pandemic. Hosted by comedian Lee Yong-jin and radio announcer Park Seon-young, the ceremony was broadcast online through KakaoTV, Melon, and 1theK's official YouTube channel. Artists who released music between November 11, 2020, and November 7, 2021, were eligible for and honored at the awards.