About: ATP cone

Property	Value
dbo:abstract	In molecular biology, the ATP-cone is an evolutionarily mobile, ATP-binding regulatory domain which is found in a variety of proteins including ribonucleotide reductases, phosphoglycerate kinases and transcriptional regulators. In ribonucleotide reductase protein R1 from Escherichia coli this domain is located at the N terminus, and is composed mostly of helices. It forms part of the allosteric effector region and contains the general allosteric activity site in a cleft located at the tip of the N-terminal region. This site binds either ATP (activating) or dATP (inhibitory), with the base bound in a hydrophobic pocket and the phosphates bound to basic residues. Substrate binding to this site is thought to affect enzyme activity by altering the relative positions of the two subunits of ribonucleotide reductase. (en)
dbo:symbol	ATP-cone
dbo:thumbnail	wiki-commons:Special:FilePath/PDB_7r1r_EBI.jpg?width=300
dbo:wikiPageID	32149638 (xsd:integer)
dbo:wikiPageLength	2581 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1032042711 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Allosteric_regulation dbr:Ribonucleotide_reductase dbr:Gene_regulation dbr:Protein_subunit dbr:Transcription_(genetics) dbr:Reductase dbr:Allosteric dbr:Alpha_helix dbr:Binding_(molecular) dbr:Enzyme_activity dbr:Protein_domain dbr:Protein dbc:Protein_domains dbr:Effector_(biology) dbr:Phosphate dbr:Evolutionary dbr:Hydrophobic dbr:Ribonucleotide dbr:Kinases dbr:Enzyme_substrate
dbp:caption	ribonucleotide reductase e441q mutant r1 protein from escherichia coli (en)
dbp:interpro	IPR005144 (en)
dbp:name	ATP-cone (en)
dbp:pfam	PF03477 (en)
dbp:scop	7 (xsd:integer)
dbp:symbol	ATP-cone (en)
dbp:wikiPageUsesTemplate	dbt:Infobox_protein_family dbt:InterPro_content dbt:Orphan dbt:Reflist
dct:subject	dbc:Protein_domains
rdf:type	owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Protein yago:SocialGroup107950920 yago:Unit108189659
rdfs:comment	In molecular biology, the ATP-cone is an evolutionarily mobile, ATP-binding regulatory domain which is found in a variety of proteins including ribonucleotide reductases, phosphoglycerate kinases and transcriptional regulators. (en)
rdfs:label	ATP cone (en)
owl:sameAs	freebase:ATP cone wikidata:ATP cone https://global.dbpedia.org/id/2KitX
prov:wasDerivedFrom	wikipedia-en:ATP_cone?oldid=1032042711&ns=0
foaf:depiction	wiki-commons:Special:FilePath/PDB_7r1r_EBI.jpg
foaf:isPrimaryTopicOf	wikipedia-en:ATP_cone
is foaf:primaryTopic of	wikipedia-en:ATP_cone