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- CDKN2B-AS, also known as ANRIL (antisense non-coding RNA in the INK4 locus) is a long non-coding RNA consisting of 19 exons, spanning 126.3kb in the genome, and its spliced product is a 3834bp RNA. It is located within the p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster, in the antisense direction. Single nucleotide polymorphisms (SNPs) which alter the expression of CDKN2B-AS are associated with human healthy life expectancy, as well as with multiple diseases, including coronary artery disease, diabetes and many cancers. It binds to chromobox 7 (CBX7) within the polycomb repressive complex 1 and to SUZ12, a component of polycomb repression complex 2 and through these interactions is involved in transcriptional repression. (en)
- CDKN2B-AS亦被称为ANRIL（INK4基因座中反义非编码RNA，英語：antisense non-coding RNA in the INK4 locus）是一条由19个外显子组成的长链非编码RNA，在基因组中横跨12.63万个碱基对，转录产物被剪接为长3834个碱基的RNA。该长链位于p15-p16-p14ARF基因座中且与蛋白编码基因呈反义方向转录。一些位于CDKN2B-AS的單核苷酸多態性位点（SNPs）改变其表达量，并与冠狀動脈性心臟病、糖尿病及多种癌症在内的许多疾病呈关联性。该条长链与中的克罗莫框7（）及中的SUZ12相结合，并通过与这两种多梳蛋白相互作用引起其它基因转录沉默。 (zh)
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- Predicted secondary structure and sequence conservation of CDKN2B-AS (en)
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- CDKN2B antisense RNA 1 intronic conserved region (en)
- CDKN2B antisense RNA 1 intronic convserved region (en)
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- CDKN2B-AS, also known as ANRIL (antisense non-coding RNA in the INK4 locus) is a long non-coding RNA consisting of 19 exons, spanning 126.3kb in the genome, and its spliced product is a 3834bp RNA. It is located within the p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster, in the antisense direction. Single nucleotide polymorphisms (SNPs) which alter the expression of CDKN2B-AS are associated with human healthy life expectancy, as well as with multiple diseases, including coronary artery disease, diabetes and many cancers. It binds to chromobox 7 (CBX7) within the polycomb repressive complex 1 and to SUZ12, a component of polycomb repression complex 2 and through these interactions is involved in transcriptional repression. (en)
- CDKN2B-AS亦被称为ANRIL（INK4基因座中反义非编码RNA，英語：antisense non-coding RNA in the INK4 locus）是一条由19个外显子组成的长链非编码RNA，在基因组中横跨12.63万个碱基对，转录产物被剪接为长3834个碱基的RNA。该长链位于p15-p16-p14ARF基因座中且与蛋白编码基因呈反义方向转录。一些位于CDKN2B-AS的單核苷酸多態性位点（SNPs）改变其表达量，并与冠狀動脈性心臟病、糖尿病及多种癌症在内的许多疾病呈关联性。该条长链与中的克罗莫框7（）及中的SUZ12相结合，并通过与这两种多梳蛋白相互作用引起其它基因转录沉默。 (zh)
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- CDKN2BAS (en)
- CDKN2BAS (zh)
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