Li-Huei Tsai (Chinese: 蔡立慧) is a neuroscientist and the director of the Picower Institute for Learning and Memory in the Department of Brain and Cognitive Sciences at the Massachusetts Institute of Technology. She is known for her work on neurological disorders that affect learning and memory, particularly for her research on Alzheimer’s disease and the role of CDK5 and chromatin remodeling in the progression of the disease. Additionally, her laboratory has innovated numerous applications of induced pluripotent stem cells for in vitro modeling of neurological diseases.