Marie Smallface Marule (Isstoikamo¹saakii, 1944 – December 31, 2014) was a Canadian academic administrator, activist, and educator. She served as executive director of the National Indian Brotherhood (NIB), chief administrator of the World Council of Indigenous Peoples (WCIP), and secretary of the Indian Association of Alberta. Marule was president of Red Crow Community College for two decades, and led the creation of several indigenous studies programs. She was previously an assistant professor of Native American studies at the University of Lethbridge.