About: Monocrotaline

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Monocrotaline (MCT) is a pyrrolizidine alkaloid that is present in plants of the Crotalaria genus. These species can synthesise MCT out of amino acids and can cause liver, lung and kidney damage in various organisms. Initial stress factors are released intracellular upon binding of MCT to BMPR2 receptors and elevated MAPK phosphorylation levels are induced, which can cause cancer in Homo sapiens. MCT can be detoxified in rats via oxidation, followed by glutathione-conjugation and hydrolysis.

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  • Monocrotalin ist ein Alkaloid und gehört aufgrund seiner Struktur zur Gruppe der Pyrrolizidinalkaloide. Es ist pflanzlichen Ursprungs und giftig. (de)
  • Monocrotaline (MCT) is a pyrrolizidine alkaloid that is present in plants of the Crotalaria genus. These species can synthesise MCT out of amino acids and can cause liver, lung and kidney damage in various organisms. Initial stress factors are released intracellular upon binding of MCT to BMPR2 receptors and elevated MAPK phosphorylation levels are induced, which can cause cancer in Homo sapiens. MCT can be detoxified in rats via oxidation, followed by glutathione-conjugation and hydrolysis. (en)
dbo:alternativeName
  • (en)
  • Crotaline (en)
  • Retronecine cyclic 2,3-dihydroxy-2,3,4-trimethylglutarate (en)
  • (-)-Monocrotaline (en)
dbo:iupacName
  • (1R,4R,5R,6R,16R)-5,6-dihydroxy-4,5,6-trimethyl-2,8-dioxa-13-azatricyclo[8.5.1.013,16]hexadec-10-ene-3,7-dione (en)
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  • 70148516 (xsd:integer)
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  • 16998 (xsd:nonNegativeInteger)
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  • 1098568046 (xsd:integer)
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  • Chemical structure of monocrotaline (en)
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  • Monocrotaline.svg (en)
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  • Skeleton formula of a carbon ring, containing oxygen, hydrogen and nitrogen atoms. It is supposed to be monocrotaline (en)
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  • -56 (xsd:integer)
dbp:othernames
  • (en)
  • Crotaline (en)
  • -Monocrotaline (en)
  • Retronecine cyclic 2,3-dihydroxy-2,3,4-trimethylglutarate (en)
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  • Monocrotalin ist ein Alkaloid und gehört aufgrund seiner Struktur zur Gruppe der Pyrrolizidinalkaloide. Es ist pflanzlichen Ursprungs und giftig. (de)
  • Monocrotaline (MCT) is a pyrrolizidine alkaloid that is present in plants of the Crotalaria genus. These species can synthesise MCT out of amino acids and can cause liver, lung and kidney damage in various organisms. Initial stress factors are released intracellular upon binding of MCT to BMPR2 receptors and elevated MAPK phosphorylation levels are induced, which can cause cancer in Homo sapiens. MCT can be detoxified in rats via oxidation, followed by glutathione-conjugation and hydrolysis. (en)
rdfs:label
  • Monocrotalin (de)
  • Monocrotaline (en)
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