About: Narlaprevir

Property	Value
dbo:abstract	Narlaprevir (trade name Arlansa, codenamed SCH 900518), is an inhibitor of NS3/4A serine protease, intended for the treatment of chronic hepatitis C caused by genotype 1 virus in combination with other antiviral drugs. Narlaprevir is the first Russian tableted medication for the treatment of chronic hepatitis C. (en) Нарлапреви́р (SCH 900518) — ингибитор NS3/4A сериновой протеазы второго поколения, предназначенный для лечения хронического гепатита С (генотип 1) в комбинации с другими противовирусными препаратами. Первый российский таблетированный препарат для лечения хронического вирусного гепатита С. С 2018 года входит в перечень ЖНВЛП. (ru)
dbo:alternativeName	Arlansa (en)
dbo:casNumber	865466-24-6
dbo:chEBI	173104
dbo:chEMBL	1255891
dbo:fdaUniiCode	2857LA2O07
dbo:kegg	D09644
dbo:pubchem	11857239
dbo:thumbnail	wiki-commons:Special:FilePath/Narlaprevir.svg?width=300
dbo:wikiPageID	52672538 (xsd:integer)
dbo:wikiPageLength	12765 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1101830576 (xsd:integer)
dbo:wikiPageWikiLink	dbc:Sulfones dbr:Pregnancy dbr:Enzyme_inhibitor dbr:Mutation dbr:NS3_(HCV) dbr:Boceprevir dbr:Antiviral_drug dbr:Ribavirin dbr:Ritonavir dbr:DNA_replication dbr:United_States dbc:Cyclopropanes dbc:Ureas dbr:Russia dbr:Oral_administration dbr:R-Pharm dbr:Cirrhosis dbr:NS4A dbr:Lactase dbr:Lactation dbr:Liver dbr:Clinical_trial dbr:Active_site dbr:Cell_(biology) dbr:Drug_resistance dbr:Amide dbc:Carboxamides dbr:Protease dbc:Heterocyclic_compounds_with_2_rings dbc:NS3/4A_protease_inhibitors dbr:Telaprevir dbr:Covalent_bond dbr:Lactose_intolerance dbr:Hepatitis_C_virus dbr:CYP3A4 dbr:Interferon_alfa-2b dbr:Merck_&_Co. dbr:Cathepsin_B dbr:Neutropenia dbr:Liver_failure dbr:Pharmacokinetics dbr:Serine_protease
dbp:atcPrefix	J05 (en)
dbp:atcSuffix	AE (en)
dbp:c	36 (xsd:integer)
dbp:casNumber	865466 (xsd:integer)
dbp:chebi	173104 (xsd:integer)
dbp:chembl	1255891 (xsd:integer)
dbp:chemspiderid	ID10031710 (en)
dbp:excretion	Feces , urine (en)
dbp:h	61 (xsd:integer)
dbp:iupacName	-3 (xsd:integer)
dbp:jmol	None (en)
dbp:kegg	D09644 (en)
dbp:legalStatus	℞-only (en)
dbp:metabolism	Extensive hepatic through oxidation, reduction and N-dealkylation (en)
dbp:n	5 (xsd:integer)
dbp:o	7 (xsd:integer)
dbp:proteinBound	86.500000 (xsd:double)
dbp:pubchem	11857239 (xsd:integer)
dbp:routesOfAdministration	dbr:Oral_administration
dbp:s	1 (xsd:integer)
dbp:smiles	CCCC[C@H]CCNC4CC4 (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	RICZEKWVNZFTNZ-LFGITCQGSA-N (en)
dbp:synonyms	SCH 900518 (en)
dbp:tradename	Arlansa (en)
dbp:unii	2857 (xsd:integer)
dbp:width	275 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Cite_journal dbt:Infobox_drug dbt:Refbegin dbt:Refend dbt:Reflist dbt:Fdacite dbt:RNA_antivirals
dcterms:subject	dbc:Sulfones dbc:Cyclopropanes dbc:Ureas dbc:Carboxamides dbc:Heterocyclic_compounds_with_2_rings dbc:NS3/4A_protease_inhibitors
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug
rdfs:comment	Narlaprevir (trade name Arlansa, codenamed SCH 900518), is an inhibitor of NS3/4A serine protease, intended for the treatment of chronic hepatitis C caused by genotype 1 virus in combination with other antiviral drugs. Narlaprevir is the first Russian tableted medication for the treatment of chronic hepatitis C. (en) Нарлапреви́р (SCH 900518) — ингибитор NS3/4A сериновой протеазы второго поколения, предназначенный для лечения хронического гепатита С (генотип 1) в комбинации с другими противовирусными препаратами. Первый российский таблетированный препарат для лечения хронического вирусного гепатита С. С 2018 года входит в перечень ЖНВЛП. (ru)
rdfs:label	Narlaprevir (en) Нарлапревир (ru)
owl:sameAs	wikidata:Narlaprevir dbpedia-fa:Narlaprevir dbpedia-ru:Narlaprevir https://global.dbpedia.org/id/2YS5Z yago-res:Narlaprevir
prov:wasDerivedFrom	wikipedia-en:Narlaprevir?oldid=1101830576&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Narlaprevir.svg
foaf:isPrimaryTopicOf	wikipedia-en:Narlaprevir
is dbo:wikiPageWikiLink of	dbr:List_of_drugs:_N–Na
is foaf:primaryTopic of	wikipedia-en:Narlaprevir