About: Ripasudil

Property	Value
dbo:abstract	Ripasudil (trade name Glanatec), a derivative of fasudil, is a rho kinase inhibitor drug (previously known as K-115) used for the treatment of glaucoma and ocular hypertension. (en) リパスジル（Ripasudil）は、Rhoキナーゼ阻害剤（ROCK阻害薬）の1種。RhoキナーゼのアイソフォームのヒトROCK-1及びROCK-2に対して選択的な阻害作用を示す。眼科領域でリパスジル塩酸塩水和物（Ripasudil Hydrochloride Hydrate）として緑内障の点眼治療剤として使用される。商品名「グラナテック」（Glanatec）。糖尿病性網膜症の治療薬としても臨床試験が進められている。 (ja)
dbo:alternativeName	Glanatec (en)
dbo:casNumber	223645-67-8
dbo:fdaUniiCode	11978226XX
dbo:kegg	D10463
dbo:pubchem	9863672
dbo:thumbnail	wiki-commons:Special:FilePath/Ripasudil.svg?width=300
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dbo:wikiPageWikiLink	dbr:Carbonic_anhydrase dbr:Endothelin_receptor dbr:Trabecular_meshwork dbr:Aqueous_humour dbr:Derivative_(chemistry) dbr:Intraocular_pressure dbr:Lethal_dose dbc:Organofluorides dbr:Maximum_tolerated_dose dbr:No-observed-adverse-effect_level dbr:Fuchs'_dystrophy dbr:Conjunctiva dbr:Corneal_endothelium dbr:Calcium-activated_potassium_channel dbr:Pharmaceuticals_and_Medical_Devices_Agency dbr:Muscarinic_acetylcholine_receptor dbc:Ophthalmology_drugs dbr:Glaucoma dbr:HMG-CoA_reductase dbr:Actomyosin dbr:Adrenergic_receptor dbr:Edema dbr:Fasudil dbr:Ciliary_body dbr:Glutamate_receptor dbr:Histamine_receptor dbr:Red_eye_(medicine) dbc:Isoquinolines dbr:Isoquinoline dbr:Angiotensin_receptor dbc:Diazepanes dbc:Protein_kinase_inhibitors dbc:Sulfonamides dbr:Diabetic_retinopathy dbr:Diazepam dbr:Fibroblast dbr:Kowa_(company) dbr:Ocular_hypertension dbr:ROCK1 dbr:Eye_drop dbr:Guttae_(medical) dbr:Thygeson's_superficial_punctate_keratopathy dbr:Topical_medication dbr:Schlemm's_canal dbr:Rho_kinase_inhibitor dbr:Prostanoid_receptor dbr:Bulbar
dbp:atcPrefix	S01 (en)
dbp:atcSuffix	EX07 (en)
dbp:c	15 (xsd:integer)
dbp:casNumber	223645 (xsd:integer)
dbp:chemspiderid	8039366 (xsd:integer)
dbp:f	1 (xsd:integer)
dbp:h	18 (xsd:integer)
dbp:iupacName	4 (xsd:integer)
dbp:kegg	D10463 (en)
dbp:n	3 (xsd:integer)
dbp:o	2 (xsd:integer)
dbp:pubchem	9863672 (xsd:integer)
dbp:routesOfAdministration	Topical (en)
dbp:s	1 (xsd:integer)
dbp:smiles	O=SN3[C@H]C (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	QSKQVZWVLOIIEV-NSHDSACASA-N (en)
dbp:synonyms	K-115 (en)
dbp:tradename	Glanatec (en)
dbp:unii	11978226 (xsd:integer)
dbp:width	119 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Infobox_drug dbt:Reflist dbt:Cascite dbt:Fdacite dbt:Antiglaucoma_preparations_and_miotics
dct:subject	dbc:Organofluorides dbc:Ophthalmology_drugs dbc:Isoquinolines dbc:Diazepanes dbc:Protein_kinase_inhibitors dbc:Sulfonamides
gold:hypernym	dbr:Drug
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug
rdfs:comment	Ripasudil (trade name Glanatec), a derivative of fasudil, is a rho kinase inhibitor drug (previously known as K-115) used for the treatment of glaucoma and ocular hypertension. (en) リパスジル（Ripasudil）は、Rhoキナーゼ阻害剤（ROCK阻害薬）の1種。RhoキナーゼのアイソフォームのヒトROCK-1及びROCK-2に対して選択的な阻害作用を示す。眼科領域でリパスジル塩酸塩水和物（Ripasudil Hydrochloride Hydrate）として緑内障の点眼治療剤として使用される。商品名「グラナテック」（Glanatec）。糖尿病性網膜症の治療薬としても臨床試験が進められている。 (ja)
rdfs:label	リパスジル (ja) Ripasudil (en)
owl:sameAs	freebase:Ripasudil yago-res:Ripasudil wikidata:Ripasudil dbpedia-ja:Ripasudil https://global.dbpedia.org/id/zmrQ
prov:wasDerivedFrom	wikipedia-en:Ripasudil?oldid=1072213125&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Ripasudil.svg
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is foaf:primaryTopic of	wikipedia-en:Ripasudil