| dbo:abstract
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- Les Slit forment une famille de glycoprotéines jouant un rôle important dans le neurodéveloppement des bilatériens. (fr)
- Slit is a family of secreted extracellular matrix proteins which play an important signalling role in the neural development of most bilaterians (animals with bilateral symmetry). While lower animal species, including insects and nematode worms, possess a single Slit gene, humans, mice and other vertebrates possess three Slit homologs: Slit1, Slit2 and Slit3. Human Slits have been shown to be involved in certain pathological conditions, such as cancer and inflammation. The ventral midline of the central nervous system is a key place where axons can either decide to cross and laterally project or stay on the same side of the brain. The main function of Slit proteins is to act as midline repellents, preventing the crossing of through the midline of the central nervous system of most bilaterian animal species, including mice, chickens, humans, insects, nematode worms and planarians. It also prevents the recrossing of . Its canonical receptor is Robo but it may have other receptors. The Slit protein is produced and secreted by cells within the floor plate (in vertebrates) or by midline glia (in insects) and diffuses outward. Slit/Robo signaling is important in pioneer axon guidance. (en)
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| dbo:arm
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| dbo:band
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| dbo:chromosome
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| dbo:entrezgene
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| dbo:hgncid
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| dbo:locusSupplementaryData
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| dbo:omim
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- 603742 (xsd:integer)
- 603745 (xsd:integer)
- 603746 (xsd:integer)
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| dbo:refseq
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- NM_003061
- NM_003062
- NM_004787
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| dbo:symbol
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- SLIL1
- SLIL2
- SLIL3
- SLIT1
- SLIT2
- SLIT3
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| dbo:thumbnail
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| dbo:uniprot
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| dbo:wikiPageID
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| dbo:wikiPageLength
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- 16964 (xsd:nonNegativeInteger)
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| dbo:wikiPageRevisionID
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| dbo:wikiPageWikiLink
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| dbp:altsymbols
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- SLIL1 (en)
- SLIL2 (en)
- SLIL3 (en)
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| dbp:arm
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| dbp:band
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- 15.200000 (xsd:double)
- 23.300000 (xsd:double)
- 35 (xsd:integer)
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| dbp:chromosome
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- 4 (xsd:integer)
- 5 (xsd:integer)
- 10 (xsd:integer)
- 2.0 (dbd:degreeRankine)
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| dbp:entrezchromosome
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| dbp:entrezgene
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- 6585 (xsd:integer)
- 6586 (xsd:integer)
- 9353 (xsd:integer)
- 36746 (xsd:integer)
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| dbp:genlocEnd
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| dbp:genlocStart
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| dbp:hgncid
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- 11085 (xsd:integer)
- 11086 (xsd:integer)
- 11087 (xsd:integer)
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| dbp:locussupplementarydata
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| dbp:name
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| dbp:omim
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- 603742 (xsd:integer)
- 603745 (xsd:integer)
- 603746 (xsd:integer)
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| dbp:organism
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- Drosophila melanogaster (en)
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| dbp:refseq
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- NM_003061 (en)
- NM_003062 (en)
- NM_004787 (en)
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| dbp:refseqmrna
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| dbp:refseqprotein
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| dbp:symbol
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| dbp:taxid
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| dbp:uniprot
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- O75093 (en)
- O75094 (en)
- O94813 (en)
- P24014 (en)
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| dbp:wikiPageUsesTemplate
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| dct:subject
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| rdf:type
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| rdfs:comment
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- Les Slit forment une famille de glycoprotéines jouant un rôle important dans le neurodéveloppement des bilatériens. (fr)
- Slit is a family of secreted extracellular matrix proteins which play an important signalling role in the neural development of most bilaterians (animals with bilateral symmetry). While lower animal species, including insects and nematode worms, possess a single Slit gene, humans, mice and other vertebrates possess three Slit homologs: Slit1, Slit2 and Slit3. Human Slits have been shown to be involved in certain pathological conditions, such as cancer and inflammation. (en)
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| rdfs:label
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- Slit (fr)
- Slit (protein) (en)
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| owl:sameAs
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| prov:wasDerivedFrom
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| foaf:depiction
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| foaf:isPrimaryTopicOf
| |
| foaf:name
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- slit homolog 1 (en)
- slit homolog 2 (en)
- slit homolog 3 (en)
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| is dbo:wikiPageDisambiguates
of | |
| is dbo:wikiPageRedirects
of | |
| is dbo:wikiPageWikiLink
of | |
| is foaf:primaryTopic
of | |
