The Smoky Mountain Conference – officially the Smoky Mountain Athletic Conference – was an intercollegiate athletic conference that existed from December 1926 to October 1966. Most teams in the league were located in Tennessee, and there were at times teams from Virginia and North Carolina. The first commissioner of the league was W. O. "Chink" Lowe, who had played college football for the Tennessee Volunteers; he served as commissioner until September 1941.