IN THIS ISSUE [1]

• Note from the Editor

  Terri Grodzicker

SPECIAL SECTION: PERSPECTIVE [1]

• Epigenetics and transcription regulation during eukaryotic diversification: the saga of TFIID

  Simona V. Antonova ... Berend Snel

SPECIAL SECTION: REVIEWS [5]

• PRC2 is high maintenance

  Jia-Ray Yu ... Danny Reinberg
• Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer

  Adrian P. Bracken ... C. Peter Verrijzer
• Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation

  Leighton Core, Karen Adelman
• MITF—the first 25 years

  Colin R. Goding, Heinz Arnheiter
• Transcription-mediated replication hindrance: a major driver of genome instability

  Belén Gómez-González, Andrés Aguilera

OUTLOOK [1]

• Dosage compensation plans: protein aggregation provides additional insurance against aneuploidy

  Rahul S. Samant ... Judith Frydman

RESEARCH PAPERS [4]

• Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells

  Christopher M. Brennan ... Angelika Amon
• Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3

  Saifeng Wang ... Stefan A. Muljo
• KLF4 protein stability regulated by interaction with pluripotency transcription factors overrides transcriptional control

  Navroop K. Dhaliwal ... Jennifer A. Mitchell
• The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation

  Shengyi Sun ... David J. Mangelsdorf