Abstract
Neonates represent a vulnerable population for infections and neonatal sepsis is a major cause of mortality and morbidity worldwide. Therefore, antimicrobials are the most commonly prescribed drugs in the Neonatal Intensive Care Unit Setting but unfortunately are quite often used inappropriately with various short and long-term effects. The rational use of antimicrobials is of paramount importance in this population and structured antimicrobial stewardship interventions should be in place. These interventions are slightly different from those used in adults and older children due to the particularities of the neonatal medicine. The aim of this review is to provide an update in the field and identify areas for further consideration and future research.
Keywords: Antimicrobial stewardship, neonate, interventions, pathogens, Candida, therapeutic challenges.
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In early life, organs and hormonal axes are especially susceptible to changes that can affect the intestinal mucosa, immune system, and long-term health. Critical factors in the developmental process, including maternal diet, type of delivery, breastfeeding, and the nutritional status of mothers and children, have gained prominence. Evidence suggests that ...read more
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