Natural and Synthetic Retinoids: Structural Bases and Biological Effects of Potential Clinical Relevance for the Prevention and Treatment of Infection-Driven Tumors

Title: Natural and Synthetic Retinoids: Structural Bases and Biological Effects of Potential Clinical Relevance for the Prevention and Treatment of Infection-Driven Tumors

Volume: 5 Issue: 1

Author(s): Riccardo Dolcetti, Dario D. Luca and Angel R. de Lera

Affiliation:

Keywords: Retinoids, rexinoids, RARs, RXRs, epstein-barr virus, human herpesvirus 8, human immunodeficiency virus

Abstract: Retinoids play a critical role in the regulation of cell division, growth, differentiation, and proliferation, and represent an exciting new avenue for _targeted therapy of different diseases, including cancer. Natural and synthetic retinoids are also endowed with antiviral properties that make these compounds particularly attractive for the prevention and treatment of infection-driven tumors. In this review, we will summarize the structural bases and the cellular and antiviral effects of retinoids which provide a molecular basis for the management of virus-associated tumors, including Kaposis sarcoma (HHV-8) and post-transplant lymphoproliferative disorders (EBV). Particular relevance will be given to the selectivity of these retinoids for their cognate receptors (RAR and RXR) in order to establish a link between receptor modulation and antiviral/antitumor effects.

Cite this article as:

Dolcetti Riccardo, Luca D. Dario and de Lera R. Angel, Natural and Synthetic Retinoids: Structural Bases and Biological Effects of Potential Clinical Relevance for the Prevention and Treatment of Infection-Driven Tumors, Anti-Infective Agents in Medicinal Chemistry 2006; 5 (1) . https://dx.doi.org/10.2174/187152106774755617