Antiproliferative activities of citrus flavonoids against six human cancer cell lines
- PMID: 12358447
- DOI: 10.1021/jf020121d
Antiproliferative activities of citrus flavonoids against six human cancer cell lines
Abstract
Citrus fruits contain high concentrations of several classes of phenols, including numerous hydroxycinnamates, flavonoid glycosides, and polymethoxylated flavones. The latter group of compounds occurs without glycosidic linkages and has been shown to inhibit the proliferation of a number of cancer cell lines. This antiproliferative property was further demonstrated against additional human cancer cell lines, and the antiproliferative actions of a series of synthetic methoxylated flavones were also studied. Similar to the naturally occurring compounds, the synthetic compounds exhibited strong antiproliferative activities. In many cases the IC(50) values occurred below 10 microm. Other hydroxylated flavone and flavanone aglycons also exhibited antiproliferative activities against the cancer cell lines, with the flavones showing greater activities than the flavanones. Glycosylation of these compounds removed their activity. The strong antiproliferative activities of the polymethoxylated flavones suggest that they may have use as anticancer agents in humans.
Similar articles
-
Antiproliferative activity of flavonoids on several cancer cell lines.Biosci Biotechnol Biochem. 1999 May;63(5):896-9. doi: 10.1271/bbb.63.896. Biosci Biotechnol Biochem. 1999. PMID: 10380632
-
Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines.Eur J Nutr. 1999 Jun;38(3):133-42. doi: 10.1007/s003940050054. Eur J Nutr. 1999. PMID: 10443335
-
Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro.Cancer Lett. 1991 Feb;56(2):147-52. doi: 10.1016/0304-3835(91)90089-z. Cancer Lett. 1991. PMID: 1998943
-
Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity.J Agric Food Chem. 2008 Aug 13;56(15):6185-205. doi: 10.1021/jf8006568. Epub 2008 Jul 2. J Agric Food Chem. 2008. PMID: 18593176 Review.
-
Biological properties of citrus flavonoids pertaining to cancer and inflammation.Curr Med Chem. 2001 Feb;8(2):135-53. doi: 10.2174/0929867013373723. Curr Med Chem. 2001. PMID: 11172671 Review.
Cited by
-
Proteomics-based network pharmacology and molecular docking reveal the potential mechanisms of 5,6,7,4'-tetramethoxyflavone against HeLa cancer cells.Heliyon. 2024 Oct 4;10(20):e38951. doi: 10.1016/j.heliyon.2024.e38951. eCollection 2024 Oct 30. Heliyon. 2024. PMID: 39449708 Free PMC article.
-
The Role of Adipocytes Recruited as Part of Tumor Microenvironment in Promoting Colorectal Cancer Metastases.Int J Mol Sci. 2024 Jul 30;25(15):8352. doi: 10.3390/ijms25158352. Int J Mol Sci. 2024. PMID: 39125923 Free PMC article. Review.
-
Comprehensive identifying flavonoids in Citri Reticulatae Pericarpium using a novel strategy based on precursor ions locked and _targeted MS/MS analysis.Sci Rep. 2024 Apr 27;14(1):9679. doi: 10.1038/s41598-024-60415-w. Sci Rep. 2024. PMID: 38678045 Free PMC article.
-
Comparative Evaluation of Secondary Metabolite Chemodiversity of Citrus Genebank Collection in Greece: Can the Peel be More than Waste?J Agric Food Chem. 2024 Apr 24;72(16):9019-9032. doi: 10.1021/acs.jafc.4c00486. Epub 2024 Apr 13. J Agric Food Chem. 2024. PMID: 38613500 Free PMC article.
-
Sinensetin suppresses breast cancer cell progression via Wnt/β-catenin pathway inhibition.Transl Cancer Res. 2024 Jan 31;13(1):348-362. doi: 10.21037/tcr-23-1317. Epub 2024 Jan 12. Transl Cancer Res. 2024. PMID: 38410229 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
