doi: 10.1089/rej.2005.8.3.
Selective mitochondrial autophagy, or mitophagy, as a _targeted defense against oxidative stress, mitochondrial dysfunction, and aging
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- PMID: 15798367
- DOI: 10.1089/rej.2005.8.3
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Selective mitochondrial autophagy, or mitophagy, as a _targeted defense against oxidative stress, mitochondrial dysfunction, and aging
Rejuvenation Res.
2005 Spring.
Abstract
In autophagy, portions of cytoplasm are sequestered into autophagosomes and delivered to lysosomes for degradation. Long assumed to be a random process, increasing evidence suggests that autophagy of mitochondria, peroxisomes, and possibly other organelles is selective. A recent paper (Kissova et al., J. Biol. Chem. 2004;279:39068-39074) shows in yeast that a specific outer membrane protein, Uth1p, is required for efficient mitochondrial autophagy. For this selective autophagy of mitochondria, we propose the term "mitophagy" to emphasize the non-random nature of the process. Mitophagy may play a key role in retarding accumulation of somatic mutations of mtDNA with aging.
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