Recent advances in tRNA mitochondrial import
- PMID: 18513973
- DOI: 10.1016/j.tibs.2008.04.010
Recent advances in tRNA mitochondrial import
Abstract
In many eukaryotes, tRNA import from the cytosol into mitochondria is essential for mitochondrial biogenesis and, consequently, for cell viability. Recent work has begun to unravel the molecular mechanisms involved in tRNA transport in yeast, trypanosomatids and plants. The mechanisms of tRNA _targeting to, and translocation through, the double mitochondrial membrane in addition to how selectivity and regulation of these processes are achieved are the main questions that have been addressed. The characterization of both direct and co-import mechanisms involving distinct protein-import factors is in agreement with a polyphyletic origin of tRNA import. Moreover, our increased understanding of the tRNA-import pathway has been exploited recently to rescue dysfunctions associated with mitochondrial tRNA mutations.
Similar articles
-
Leishmania mitochondrial tRNA importers.Int J Biochem Cell Biol. 2008;40(12):2681-5. doi: 10.1016/j.biocel.2007.10.025. Epub 2007 Nov 20. Int J Biochem Cell Biol. 2008. PMID: 18061510 Review.
-
The voltage-dependent anion channel, a major component of the tRNA import machinery in plant mitochondria.Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18362-7. doi: 10.1073/pnas.0606449103. Epub 2006 Nov 14. Proc Natl Acad Sci U S A. 2006. PMID: 17105808 Free PMC article.
-
Nuclear DNA-encoded tRNAs _targeted into mitochondria can rescue a mitochondrial DNA mutation associated with the MERRF syndrome in cultured human cells.Hum Mol Genet. 2004 Oct 15;13(20):2519-34. doi: 10.1093/hmg/ddh267. Epub 2004 Aug 18. Hum Mol Genet. 2004. PMID: 15317755
-
Sequence dependence of tRNA(Gly) import into tobacco mitochondria.Biochimie. 2005 Sep-Oct;87(9-10):863-72. doi: 10.1016/j.biochi.2005.04.004. Biochimie. 2005. PMID: 15927343
-
[Are there distinct mechanisms of mitochondrial tRNA import in higher plants?].Tanpakushitsu Kakusan Koso. 2005 Nov;50(14 Suppl):1799-800. Tanpakushitsu Kakusan Koso. 2005. PMID: 16318320 Review. Japanese. No abstract available.
Cited by
-
Trafficking of mitochondrial double-stranded RNA from mitochondria to the cytosol.Life Sci Alliance. 2024 Jul 2;7(9):e202302396. doi: 10.26508/lsa.202302396. Print 2024 Sep. Life Sci Alliance. 2024. PMID: 38955468 Free PMC article.
-
Evolutionary and phylogenetic insights from the mitochondrial genomic analysis of Diceraeus melacanthus and D. furcatus (Hemiptera: Pentatomidae).Sci Rep. 2024 Jun 4;14(1):12861. doi: 10.1038/s41598-024-63584-w. Sci Rep. 2024. PMID: 38834792 Free PMC article.
-
ANT2 functions as a translocon for mitochondrial cross-membrane translocation of RNAs.Cell Res. 2024 Jul;34(7):504-521. doi: 10.1038/s41422-024-00978-5. Epub 2024 May 29. Cell Res. 2024. PMID: 38811766
-
A landscape of mouse mitochondrial small non-coding RNAs.PLoS One. 2024 Jan 2;19(1):e0293644. doi: 10.1371/journal.pone.0293644. eCollection 2024. PLoS One. 2024. PMID: 38165955 Free PMC article.
-
Mitochondrial transport of catalytic RNAs and _targeting of the organellar transcriptome in human cells.J Mol Cell Biol. 2024 Jan 17;15(8):mjad051. doi: 10.1093/jmcb/mjad051. J Mol Cell Biol. 2024. PMID: 37591617 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
