Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Apr 7;15(4):294-303.
doi: 10.1016/j.ccr.2009.02.022.

Oncogenic Braf induces melanocyte senescence and melanoma in mice

Nathalie Dhomen  1 , Jorge S Reis-Filho, Silvy da Rocha Dias, Robert Hayward, Kay Savage, Veronique Delmas, Lionel Larue, Catrin Pritchard, Richard Marais
Affiliations
Free article

Oncogenic Braf induces melanocyte senescence and melanoma in mice

Nathalie Dhomen et al. Cancer Cell. .
Free article

Abstract

We show here that inducible expression of Braf(V600E) off the endogenous Braf gene in mouse melanocytes stimulates skin hyperpigmentation and the appearance of nevi harboring senescent melanocytes. Additionally, approximately 70% of Braf(V600E) mice develop melanomas that reproduce many of the cardinal histological and molecular features of human melanoma and whose cells can colonize the lungs of nude mice. We show that the tumor suppressor p16(INK4a) is not required to induce melanocyte senescence and that its loss is not required for tumor progression, although it does regulate tumor penetrance and latency. Thus, we have developed a mouse model of melanoma driven by Braf(V600E) expressed at physiological levels that reflects the genetics and pathology of the human disease.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

Substances

LinkOut - more resources

  NODES
twitter 2