doi: 10.4161/auto.8822.
Epub 2009 Aug 21.
p65/RelA binds and activates the beclin 1 promoter
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- PMID: 19458474
- DOI: 10.4161/auto.8822
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p65/RelA binds and activates the beclin 1 promoter
Autophagy.
2009 Aug.
Abstract
We unveiled novel p65/RelA consensus sites in the promoter of the beclin 1 gene and demonstrate that p65/RelA positively modulates canonical autophagy in various human cell lines both under basal conditions and upon induction by ceramide. Interestingly, we find that T cell receptor-dependent activation of Jurkat cells triggers an increase in the binding of p65/RelA to the beclin 1 promoter accompanied by enhanced autophagy, suggesting that p65/RelA could regulate T-cell activation and homeostasis through autophagy.
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