Review
Interstitial pneumonitis in the transplant patient: consider sirolimus-associated pulmonary toxicity
Affiliations
- PMID: 19772040
Item in Clipboard
Review
Interstitial pneumonitis in the transplant patient: consider sirolimus-associated pulmonary toxicity
J La State Med Soc.
2009 May-Jun.
Abstract
Interstitial pneumonia in a transplant patient can have a varied etiology. Sirolimus (Rapamycin; Rapamune) is a popularly used immunosuppressant in solid organ transplantation that has anecdotally been associated with pulmonary toxicity. Sirolimus-induced pulmonary toxicity consists of a range of syndromes that is characterized by the presence of organizing pneumonia, interstitial pneumonitis, pulmonary alveolar proteinosis, focal fibrosis, or by the presence of alveolar hemorrhage. Diagnosis can be challenging and is usually made by exclusion of other etiologies. In this report we present two cases of sirolimus-associated pulmonary toxicity with a review of the literature.
Similar articles
-
Interstitial pneumonitis associated with sirolimus in liver transplantation: a case report.Transplant Proc. 2007 Dec;39(10):3498-9. doi: 10.1016/j.transproceed.2007.06.082. Transplant Proc. 2007. PMID: 18089419
-
Sirolimus-associated interstitial pneumonitis in solid organ transplant recipients.Clin Transplant. 2005 Oct;19(5):698-703. doi: 10.1111/j.1399-0012.2005.00356.x. Clin Transplant. 2005. PMID: 16146565
-
[Pulmonary toxicity associated with sirolimus therapy in liver transplantation].Gastroenterol Hepatol. 2006 Dec;29(10):616-8. doi: 10.1157/13095205. Gastroenterol Hepatol. 2006. PMID: 17198638 Review. Spanish.
-
Patterns of pulmonary complications associated with sirolimus.Respiration. 2006;73(3):367-74. doi: 10.1159/000087945. Epub 2005 Aug 25. Respiration. 2006. PMID: 16127266
-
Sirolimus-Induced Combined Posterior Reversible Encephalopathy Syndrome and Lymphocytic Pneumonitis in a Renal Transplant Recipient: Case Report and Review of the Literature.Exp Clin Transplant. 2017 Feb;15(Suppl 1):170-174. doi: 10.6002/ect.mesot2016.P36. Exp Clin Transplant. 2017. PMID: 28260460 Review.
Cited by
-
Rapamycin Regulates Bleomycin-Induced Lung Damage in SP-C-Deficient Mice.Pulm Med. 2011;2011:653524. doi: 10.1155/2011/653524. Epub 2011 Mar 21. Pulm Med. 2011. PMID: 21660239 Free PMC article.
-
Sirolimus-induced secondary pulmonary alveolar proteinosis.Respir Med Case Rep. 2021 Dec 15;35:101566. doi: 10.1016/j.rmcr.2021.101566. eCollection 2022. Respir Med Case Rep. 2021. PMID: 34976718 Free PMC article.
-
In Vitro Identification of New Transcriptomic and miRNomic Profiles Associated with Pulmonary Fibrosis Induced by High Doses Everolimus: Looking for New Pathogenetic Markers and Therapeutic _targets.Int J Mol Sci. 2018 Apr 20;19(4):1250. doi: 10.3390/ijms19041250. Int J Mol Sci. 2018. PMID: 29677166 Free PMC article.
-
Interstitial pneumonitis is a frequent complication in liver transplant recipients treated with sirolimus.Ir J Med Sci. 2012 Jun;181(2):231-5. doi: 10.1007/s11845-011-0789-y. Epub 2012 Jan 15. Ir J Med Sci. 2012. PMID: 22246568
-
Pulmonary alveolar proteinosis due to mycophenolate and cyclosporine combination therapy in a renal transplant recipient.Lung India. 2014 Jul;31(3):282-4. doi: 10.4103/0970-2113.135782. Lung India. 2014. PMID: 25125821 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical