Review
doi: 10.1002/cbdv.200900343.
Locked nucleic acids: promising nucleic acid analogs for therapeutic applications
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- PMID: 20232325
- DOI: 10.1002/cbdv.200900343
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Review
Locked nucleic acids: promising nucleic acid analogs for therapeutic applications
Chem Biodivers.
2010 Mar.
Free article
Abstract
Locked Nucleic Acid (LNA) is a unique nucleic-acid modification possessing very high binding affinity and excellent specificity toward complementary RNA or DNA oligonucleotides. The remarkable properties exhibited by LNA oligonucleotides have been employed in different nucleic acid-based therapeutic strategies both in vitro and in vivo. Herein, we highlight the applications of LNA nucleotides for controlling gene expression.
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