Review
doi: 10.1002/wrna.47.
Epub 2010 Sep 20.
Alternative mRNA polyadenylation in eukaryotes: an effective regulator of gene expression
Affiliations
- PMID: 21956967
- DOI: 10.1002/wrna.47
Item in Clipboard
Review
Alternative mRNA polyadenylation in eukaryotes: an effective regulator of gene expression
Wiley Interdiscip Rev RNA.
2011 Jan-Feb.
Abstract
Alternative RNA processing mechanisms, including alternative splicing and alternative polyadenylation, are increasingly recognized as important regulators of gene expression. This article will focus on what has recently been described about alternative polyadenylation in development, differentiation, and disease in higher eukaryotes. We will also describe how the evolving global methodologies for examining the cellular transcriptome, both experimental and bioinformatic, are revealing new details about the complex nature of alternative 3(') end formation as well as interactions with other RNA-mediated and RNA processing mechanisms.
Copyright © 2010 John Wiley & Sons, Ltd.
Similar articles
-
Alternative mRNA polyadenylation in eukaryotes: an effective regulator of gene expression.Wiley Interdiscip Rev RNA. 2011 Jan-Feb;2(1):23-31. doi: 10.1002/wrna.47. Wiley Interdiscip Rev RNA. 2011. PMID: 21278855 Free PMC article. Review.
-
Immunoglobulin heavy chain gene regulation through polyadenylation and splicing competition.Wiley Interdiscip Rev RNA. 2011 Jan-Feb;2(1):92-105. doi: 10.1002/wrna.36. Wiley Interdiscip Rev RNA. 2011. PMID: 21956971 Review.
-
Alternative polyadenylation: a twist on mRNA 3' end formation.ACS Chem Biol. 2008 Oct 17;3(10):609-17. doi: 10.1021/cb800138w. Epub 2008 Sep 26. ACS Chem Biol. 2008. PMID: 18817380 Review.
-
Genome-wide alternative polyadenylation in animals: insights from high-throughput technologies.J Mol Cell Biol. 2012 Dec;4(6):352-61. doi: 10.1093/jmcb/mjs041. Epub 2012 Oct 25. J Mol Cell Biol. 2012. PMID: 23099521 Review.
-
The polyadenylation code: a unified model for the regulation of mRNA alternative polyadenylation.J Zhejiang Univ Sci B. 2014 May;15(5):429-37. doi: 10.1631/jzus.B1400076. J Zhejiang Univ Sci B. 2014. PMID: 24793760 Free PMC article. Review.
Cited by
-
The Glycine-Rich RNA-Binding Protein Is a Vital Post-Transcriptional Regulator in Crops.Plants (Basel). 2023 Oct 9;12(19):3504. doi: 10.3390/plants12193504. Plants (Basel). 2023. PMID: 37836244 Free PMC article. Review.
-
CAFuncAPA: a knowledgebase for systematic functional annotations of APA events in human cancers.NAR Cancer. 2023 Jan 23;5(1):zcad004. doi: 10.1093/narcan/zcad004. eCollection 2023 Mar. NAR Cancer. 2023. PMID: 36694725 Free PMC article.
-
Developmentally regulated alternate 3' end cleavage of nascent transcripts controls dynamic changes in protein expression in an adult stem cell lineage.Genes Dev. 2022 Aug 1;36(15-16):916-935. doi: 10.1101/gad.349689.122. Epub 2022 Sep 29. Genes Dev. 2022. PMID: 36175033 Free PMC article.
-
MCL1 alternative polyadenylation is essential for cell survival and mitochondria morphology.Cell Mol Life Sci. 2022 Mar 1;79(3):164. doi: 10.1007/s00018-022-04172-x. Cell Mol Life Sci. 2022. PMID: 35229202 Free PMC article.
-
Implications of Poly(A) Tail Processing in Repeat Expansion Diseases.Cells. 2022 Feb 15;11(4):677. doi: 10.3390/cells11040677. Cells. 2022. PMID: 35203324 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
