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. 2012 Jan;47(1):214-20.
doi: 10.1016/j.ejmech.2011.10.047. Epub 2011 Nov 4.

Induction of cell cycle arrest by the carbazole alkaloid Clauszoline-I from Clausena vestita D. D. Tao via inhibition of the PKCδ phosphorylation

Wei Lin  1 , Ying Wang, Sisi Lin, Cuixian Li, Chun Zhou, Shaogui Wang, Heqing Huang, Peiqing Liu, Guan Ye, Xiaoyan Shen
Affiliations

Induction of cell cycle arrest by the carbazole alkaloid Clauszoline-I from Clausena vestita D. D. Tao via inhibition of the PKCδ phosphorylation

Wei Lin et al. Eur J Med Chem. 2012 Jan.

Abstract

Sixteen carbazole alkaloids from Clausena vestita D. D. Tao were extracted, and their anti-tumor activities were evaluated. Among the extracts, Clauszoline-I exhibited an obvious growth inhibitory activity against several cancer cell lines through its ability to induce cell cycle arrest in the S and G2/M phases. A dramatic morphologic change with decreased F-actin staining and RhoA activity was found in Clauszoline-I treated HepG2 cells, in which the phosphorylation of PKCδ (Ser643) was inhibited. Our results indicated that induction cell cycle arrest by Clauszoline-I might be achieved by decreasing the RhoA activity via the inhibition of PKCδ phosphorylation.

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