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. 2012 Jun 6;12(1):22.
doi: 10.1186/1475-2867-12-22.

TRAIL and vitamins: opting for keys to castle of cancer proteome instead of open sesame

Ammad Ahmad Farooqi  1 , Shahzad Bhatti, Muhammad Ismail
Affiliations

TRAIL and vitamins: opting for keys to castle of cancer proteome instead of open sesame

Ammad Ahmad Farooqi et al. Cancer Cell Int. .

Abstract

Cancer is a multifaceted molecular disorder that is modulated by a combination of genetic, metabolic and signal transduction aberrations, which severely impair the normal homeostasis of cell growth and death. Accumulating findings highlight the fact that different genetic alterations, such as mutations in tumor suppressor genes, might be related to distinct and differential sensitivity to _targeted therapies. It is becoming increasingly apparent that a multipronged approach that addresses genetic milieu (alterations in upstream and/or parallel pathways) eventually determines the response of individual tumors to therapy. Cancerous cells often acquire the ability to evade death by attenuating cell death pathways that normally function to eliminate damaged and harmful cells. Therefore impaired cell death nanomachinery and withdrawal of death receptors from cell surface are some of major determinants for the development of chemotherapeutic resistance encountered during treatment. It is therefore essential to emphasize underlying factors which predispose cells to refractoriness against TRAIL mediated cell death pathway and the relevant regulatory components involved. We bring to limelight the strategies to re-sensitize TRAIL resistant cells via vitamins to induce apoptosis.

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Figures

Figure 1
Figure 1
Modes of internalization of death receptors.
Figure 2
Figure 2
Various routes of translocation of death receptors and decoy receptors towards cell surface.
See this image and copyright information in PMC

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