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. 2013 Nov;30(11):2785-94.
doi: 10.1007/s11095-013-1097-1. Epub 2013 Jun 6.

Drug delivery using platelet cancer cell interaction

Sounik Sarkar  1 , Mohammed Aftab Alam, Jyoti Shaw, Anjan Kr Dasgupta
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Drug delivery using platelet cancer cell interaction

Sounik Sarkar et al. Pharm Res. 2013 Nov.

Abstract

Purpose: To develop an efficient biocompatible and _targeted drug delivery system in which platelets, an essential blood component having a natural affinity for cancer cells, are used as carrier of anticancer drug as delivery of drug to the _targeted site is crucial for cancer treatment.

Methods: Doxorubicin hydrochloride, a potent anti cancer drug, was delivered in lung adenocarcinoma cell line (A549) using platelet as a delivery agent. This delivery mode was also tested in Ehrlich ascites carcinoma (EAC) bearing mice in presence and absence of platelets.

Results: The results show that platelets can uptake the drug and release the same upon activation. The efficiency of drug loaded platelets in inducing cytotoxicity was significantly higher in both in vitro and in vivo model, as compared to the free drug.

Conclusions: The proposed drug delivery strategy may lead to clinical improvement in the management of cancer treatment as lower drug concentration can be used in a _targeted mode. Additionally the method can be personalized as patient's own platelet can be used for deliver various drugs.

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