Polyphenols-rich natural products for treatment of diabetes
- PMID: 25174925
- DOI: 10.2174/0929867321666140826115422
Polyphenols-rich natural products for treatment of diabetes
Abstract
Currently, experimental and clinical evidences showed that polyphenols-rich natural products, like nutraceuticals and food supplements, may offer unique treatment modalities in type 2 diabetes mellitus (DM), due to their biological properties. Natural products modulate the carbohydrate metabolism by various mechanisms, such as restoring beta-cells integrity and physiology, enhancing insulin releasing activity, and the glucose using. Sea buckthorn berries, red grapes, bilberries, chokeberries and popular drinks like cocoa, coffee and green tea are all rich in polyphenols and may decrease the insulin response, offer in g a natural alternative of treatment in diabetes. Therefore, researches are now focused on potential efficacies of different types of polyphenols, including flavonoids, phenolic acids, lignans, anthocyans and stilbenes. Animal and human studies showed that polyphenols modulate carbohydrate and lipid metabolism, decrease glycemia and insulin resistance, increase lipid metabolism and optimize oxidative stress and inflammatory processes. It is important to understand the proper dose and duration of supplementation with polyphenols-rich extracts in order to guide effective therapeutic interventions in diabetic patients.
Similar articles
-
Polyphenols: Potential Future Arsenals in the Treatment of Diabetes.Curr Pharm Des. 2016;22(5):549-65. doi: 10.2174/1381612822666151125001111. Curr Pharm Des. 2016. PMID: 26601968 Review.
-
Food Polyphenols and Type II Diabetes Mellitus: Pharmacology and Mechanisms.Molecules. 2023 May 10;28(10):3996. doi: 10.3390/molecules28103996. Molecules. 2023. PMID: 37241737 Free PMC article. Review.
-
Dietary polyphenols as potential nutraceuticals in management of diabetes: a review.J Diabetes Metab Disord. 2013 Aug 13;12(1):43. doi: 10.1186/2251-6581-12-43. J Diabetes Metab Disord. 2013. PMID: 23938049 Free PMC article.
-
Polyphenols and Glycemic Control.Nutrients. 2016 Jan 5;8(1):17. doi: 10.3390/nu8010017. Nutrients. 2016. PMID: 26742071 Free PMC article. Review.
-
Phenolic-enriched foods: sources and processing for enhanced health benefits.Proc Nutr Soc. 2017 May;76(2):163-171. doi: 10.1017/S0029665116000835. Epub 2016 Nov 2. Proc Nutr Soc. 2017. PMID: 27804893
Cited by
-
Comparative Antidiabetic Activity of Aqueous, Ethanol, and Methanol Leaf Extracts of Persea americana and Their Effectiveness in Type 2 Diabetic Rats.Evid Based Complement Alternat Med. 2019 Oct 16;2019:5984570. doi: 10.1155/2019/5984570. eCollection 2019. Evid Based Complement Alternat Med. 2019. PMID: 31737083 Free PMC article.
-
Molecular signaling mechanisms behind polyphenol-induced bone anabolism.Phytochem Rev. 2017;16(6):1183-1226. doi: 10.1007/s11101-017-9529-x. Epub 2017 Aug 31. Phytochem Rev. 2017. PMID: 29200988 Free PMC article. Review.
-
An Overview of Plant Phenolic Compounds and Their Importance in Human Nutrition and Management of Type 2 Diabetes.Molecules. 2016 Oct 15;21(10):1374. doi: 10.3390/molecules21101374. Molecules. 2016. PMID: 27754463 Free PMC article. Review.
-
The Emerging Role of Polyphenols in the Management of Type 2 Diabetes.Molecules. 2021 Jan 29;26(3):703. doi: 10.3390/molecules26030703. Molecules. 2021. PMID: 33572808 Free PMC article. Review.
-
A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Trigonella foenum-graecum) extract (Fenfuro™) in patients with type 2 diabetes.Food Nutr Res. 2016 Oct 11;60:32382. doi: 10.3402/fnr.v60.32382. eCollection 2016. Food Nutr Res. 2016. PMID: 27733237 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
