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. 2015 Aug 6:5:179.
doi: 10.3389/fonc.2015.00179. eCollection 2015.

Sjögren Syndrome Complicated by Mucosa-Associated Lymphoid Tissue Lymphoma and Lymphocytic Interstitial Pneumonia

Fatma Ahmed  1 , Osama Raslan  1 , Razi Muzaffar  1 , Nadeem Parkar  1 , Nitin Marwaha  1 , Medhat M Osman  1
Affiliations

Sjögren Syndrome Complicated by Mucosa-Associated Lymphoid Tissue Lymphoma and Lymphocytic Interstitial Pneumonia

Fatma Ahmed et al. Front Oncol. .

Abstract

Sjögren syndrome (SS) is an autoimmune disease with exocrine glands dysfunction and multiorgan involvement. It is associated with increased risk of lymphoproliferative disorders, especially B-cell marginal zone lymphoma. While the role of F-18 Fluorodeoxyglucose position emission tomography/computed tomography (F-18 FDG PET/CT) for evaluation of lymphoma has been established, its use in patients with a chronic history of SS to evaluate for possible lymphoproliferative disorders or multiorgan involvement is limited. We present a case of chronic SS in which F-18 FDG PET/CT demonstrated FDG avid intraparotid and cervical lymph nodes pathologically proven to be mucosa-associated lymphoid tissue lymphoma. In addition, the patient had bibasilar cystic changes consistent with lymphocytic interstitial pneumonia.

Keywords: FDG PET/CT; FDG avid; LIP; MALT lymphoma; Sjögren syndrome.

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Figures

Figure 1
Figure 1
Contrast-enhanced computed tomography demonstrated fatty atrophy of the parotid glands (yellow arrow), enhancing predominately left parotid nodule (green arrow), and enlarged cervical lymph nodes (red arrows).
Figure 2
Figure 2
F-18 Fluorodeoxyglucose position emission tomography/computed tomography demonstrated FDG avid predominately left parotid nodule (green arrows) and cervical lymph nodes (red arrows), suspicious for lymphoma.
Figure 3
Figure 3
F-18 Fluorodeoxyglucose position emission tomography/computed tomography demonstrated bibasilar thin-walled lung cysts, consistent with LIP (blue arrowheads).
Figure 4
Figure 4
FNA of left parotid nodule demonstrated monotonous population of small to intermediated size atypical lymphocytes. (Top panels – Diff-Quik stain, bottom panels – Pap stain).
See this image and copyright information in PMC

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