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Review
. 2016 Oct:64:16-29.
doi: 10.1016/j.plipres.2016.08.002. Epub 2016 Aug 4.

Fat type in phytosterol products influence their cholesterol-lowering potential: A systematic review and meta-analysis of RCTs

Jessica J A Ferguson  1 , Elizabeth Stojanovski  2 , Lesley MacDonald-Wicks  3 , Manohar L Garg  4
Affiliations
Review

Fat type in phytosterol products influence their cholesterol-lowering potential: A systematic review and meta-analysis of RCTs

Jessica J A Ferguson et al. Prog Lipid Res. 2016 Oct.

Abstract

The most common form of phytosterol (PS) fortified foods are fat spreads and dairy products. The predominant fats used are soybean/sunflower (SS) or rapeseed/canola (RC) oils and animal fat (D) in dairy products. This review aimed to investigate whether the carrier fat is a determinant of the hypocholesterolaemic effects of PS fortified foods. Databases were searched using relevant keywords and published RCTs from 1990 investigating the effects of dietary PS intervention (≥1.5g per day) on total cholesterol and LDL-C were included. After methodological quality assessment and data extraction, a total of 32 RCTs (RC, n=15; SS, n=9; D, n=8) were included. As expected, all fat groups significantly reduced TC and LDL-C (p<0.01). When compared across different carrier fats, RC as the main carrier fat, reduced LDL-C significantly more than the SS spreads (p=0.01). Therefore, a combination of monounsaturated fatty acid rich spread with adequate amounts of omega-3 fatty acids (as evident in RC spreads) may be the superior carrier fat for the delivery of PS for optimal blood cholesterol-lowering. The findings of this research provide useful evidence for optimising the hypocholesterolaemic effects of PS and support further investigation into the possible mechanisms behind these findings.

Keywords: Canola; Cholesterol; Dairy; Phytosterols; Rapeseed; Sunflower.

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