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. 2016 Aug 15;8(8):3530-9.
eCollection 2016.

Downregulation of androgen receptor is strongly associated with diabetes in triple negative breast cancer patients

Francesca Collina  1 , Margherita Cerrone  1 , Valentina Peluso  1 , Michelino De Laurentiis  2 , Roberta Caputo  2 , Rossella De Cecio  1 , Giuseppina Liguori  1 , Gerardo Botti  1 , Monica Cantile  1 , Maurizio Di Bonito  1
Affiliations

Downregulation of androgen receptor is strongly associated with diabetes in triple negative breast cancer patients

Francesca Collina et al. Am J Transl Res. .

Abstract

Developing of personalized therapies for Triple Negative Breast Cancer (TNBC) requires a more detailed knowledge of its biology and a correct stratification of molecular subtypes. Androgen Receptor (AR) is expressed in a large part of TNBCs but its prognostic role in this Breast Cancer (BC) subtype is highly debated. In this study, we analyzed AR expression in a series of 238 TNBCs and correlated its expression with clinical-pathological features, survival, and metabolic profile. We showed a consistent association between AR expression and a better prognosis of TNBC patients, while its downregulation appeared strongly associated with diabetic disease. Since a recent prospective study reported a lower BC risk in diabetic women treated with drugs able to reduce circulating levels of glucose compared with non-diabetic woman, and in vitro studies showed that AR level are regulated directly by hyperglycemia, we speculate on the perspective of new integrated therapies for TNBC.

Keywords: Triple negative breast cancers; androgen receptor; diabetes.

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Figures

Figure 1
Figure 1
AR immunostaining in TNBC: A. Low expression of AR (10X); B. Detail of low expression of AR (20X); C. CK8/18 negative staining with normal tissue as positive internal control (10X); D. Detail of CK8/18 negative staining (20X).
Figure 2
Figure 2
LAR TNBC immunephenotype: A. High expression of AR (10X); B. Detail of high expression of AR (20X); C. CK8/18 positive staining (10X); D. Detail of CK8/18 positive staining (20X).
Figure 3
Figure 3
AR+ TNBC patients Kaplan-Meier curves: A. Disease Free Survival (DFS) (p=0.998); B. Overall Survival (OS) (p=0.035).
Figure 4
Figure 4
LAR TNBC patients Kaplan-Meier curves: A. Disease Free Survival (DFS) (p=0.277); B. Overall Survival (OS) (p=0.054).
See this image and copyright information in PMC

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