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. 2016 Oct 19;16(10):1733.
doi: 10.3390/s16101733.

Microwave-Based Microfluidic Sensor for Non-Destructive and Quantitative Glucose Monitoring in Aqueous Solution

Thomas Chretiennot  1 , David Dubuc  2 , Katia Grenier  3
Affiliations

Microwave-Based Microfluidic Sensor for Non-Destructive and Quantitative Glucose Monitoring in Aqueous Solution

Thomas Chretiennot et al. Sensors (Basel). .

Abstract

This paper presents a reliable microwave and microfluidic miniature sensor dedicated to the measurement of glucose concentration in aqueous solution. The device; which is integrated with microtechnologies; is made of a bandstop filter implemented in a thin film microstrip technology combined with a fluidic microchannel. Glucose aqueous solutions have been characterized for concentration ranging from 80 g/L down to 0.3 g/L and are identified with the normalized insertion loss at optimal frequency. The sensitivity of the sensor has consequently been estimated at 7.6 × 10-3 dB/(g/L); together with the experimental uncertainty; the resolution of the sensor comes to 0.4 g/L. These results demonstrate the potentialities of such a sensor for the quantitative analysis of glucose in aqueous solution.

Keywords: glucose; glycaemia; microfluidic; microwave; sensor.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Fabricated biosensor consisting of a quarter wave-length stub implemented in a thin film microstrip technology. Inlets provide the detailed architecture of the inter-digitated capacitor (IDC) equipped with the microfluidic channel and the IDC dimensions.
Figure 2
Figure 2
Simulated electric field intensity at the resonance.
Figure 3
Figure 3
Measured S21 spectra in the frequency range [0; 55] GHz for deionized water (reference liquid in this study) and a glucose solution at 80 g/L.
Figure 4
Figure 4
Block diagram of the RadioFrequency (RF) measurement setup.
Figure 5
Figure 5
Measured normalized spectra S21 for the highest eight concentrated glucose solutions in the same frequency range.
Figure 6
Figure 6
Modulus of the normalized S21 parameter at 7.5 GHz as a function of the glucose concentration.
Figure 7
Figure 7
Clarke error grid established with the lowest five glucose solutions measured on the presented biosensor.
See this image and copyright information in PMC

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References

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