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. 2018 Jul;28(6):1196-1202.
doi: 10.1097/IGC.0000000000001291.

Activity of Pembrolizumab in Recurrent Cervical Cancer: Case Series and Review of Published Data

Marlene Kranawetter  1 , Sebastian Röhrich  2 , Leonhard Müllauer  3 , Helena Obermair  4 , Alexander Reinthaller, Christoph Grimm  1 , Alina Sturdza  5 , Wolfgang J Köstler  6 , Stephan Polterauer
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Activity of Pembrolizumab in Recurrent Cervical Cancer: Case Series and Review of Published Data

Marlene Kranawetter et al. Int J Gynecol Cancer. 2018 Jul.

Abstract

Objectives: Recent data support the use of pembrolizumab in cervical cancer. The aim of this study was to investigate pembrolizumab in heavily pretreated patients with recurrent cervical cancer.

Methods: Data from consecutive patients treated with pembrolizumab at a single academic institution were assessed. Programmed cell death ligand 1 (PD-L1) status and microsatellite instability were assessed from tumor samples. Irrespective of PD-L1 expression status, pembrolizumab was administered at fixed dose of 200 mg intravenously every 3 weeks. Treatment response was evaluated by computed tomography, using iRECIST (2017) criteria. Descriptive statistics were performed. Results from previous publications were summarized.

Results: In total, 11 heavily pretreated patients with recurrent cervical cancer received pembrolizumab. Of these, 2 (18%) patients showed partial response and 2 (18%) patients showed disease stabilization on computed tomography, resulting in a clinical benefit rate of 36%. These 4 patients are still on treatment and durable antitumor activity of up to 52 weeks was observed. Treatment was generally well tolerated with 1 patient showing dose-limiting toxicity. Median overall survival was 26 (3-53) weeks, and a 6-month overall survival rate of 65% was observed. Of the 5 patients with high PD-L1 expression, 3 showed response to treatment.

Conclusions: Pembrolizumab shows promising activity in heavily pretreated patients with recurrent cervical cancer in a real-life clinical setting. Treatment was generally well tolerated, and adverse effects were manageable. Growing evidence supports the use of pembrolizumab in this group of patients.

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