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Review
. 2019 Jan;16(1):69-78.
doi: 10.1080/17425247.2019.1554647. Epub 2018 Dec 9.

Magnetic iron oxide nanoparticles for drug delivery: applications and characteristics

Thomas Vangijzegem  1 , Dimitri Stanicki  1 , Sophie Laurent  1   2
Affiliations
Review

Magnetic iron oxide nanoparticles for drug delivery: applications and characteristics

Thomas Vangijzegem et al. Expert Opin Drug Deliv. 2019 Jan.

Abstract

Introduction: For many years, the controlled delivery of therapeutic compounds has been a matter of great interest in the field of nanomedicine. Among the wide amount of drug nanocarriers, magnetic iron oxide nanoparticles (IONs) stand out from the crowd and constitute robust nanoplatforms since they can achieve high drug loading as well as _targeting abilities stemming from their remarkable properties (magnetic and biological properties). These applications require precise design of the nanoparticles regarding several parameters which must be considered together in order to attain highest therapeutic efficacy.

Areas covered: This short review presents recent developments in the field of cancer _targeted drug delivery using magnetic nanocarriers as drug delivery systems.

Expert opinion: The design of nanocarriers enabling efficient delivery of therapeutic compounds toward _targeted locations is one of the major area of research in the _targeted drug delivery field. By precisely shaping the structural properties of the iron oxide nanoparticles, drugs loaded onto the nanoparticles can be efficiently guided and selectively delivered toward _targeted locations. With these goals in mind, special attention should be given to the pharmacokinetics and in vivo behavior of the developed nanocarriers.

Keywords: Magnetic iron oxide nanoparticles; magnetically guided delivery; stimuli-responsive delivery; _targeted drug delivery; theranostics.

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