mTOR as a central hub of nutrient signalling and cell growth

doi:10.1038/s41556-018-0205-1

Review

. 2019 Jan;21(1):63-71.

doi: 10.1038/s41556-018-0205-1. Epub 2019 Jan 2.

mTOR as a central hub of nutrient signalling and cell growth

Joungmok Kim¹, Kun-Liang Guan²

Affiliations

¹ Department of Oral Biochemistry and Molecular Biology, School of Dentistry, Kyung Hee University, Seoul, Korea. jok011@khu.ac.kr.
² Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. kuguan@ucsd.edu.

PMID: 30602761
DOI: 10.1038/s41556-018-0205-1

Review

mTOR as a central hub of nutrient signalling and cell growth

Joungmok Kim et al. Nat Cell Biol. 2019 Jan.

. 2019 Jan;21(1):63-71.

doi: 10.1038/s41556-018-0205-1. Epub 2019 Jan 2.

Authors

Joungmok Kim¹, Kun-Liang Guan²

Affiliations

¹ Department of Oral Biochemistry and Molecular Biology, School of Dentistry, Kyung Hee University, Seoul, Korea. jok011@khu.ac.kr.
² Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. kuguan@ucsd.edu.

PMID: 30602761
DOI: 10.1038/s41556-018-0205-1

Abstract

The highly conserved protein kinase mechanistic _target of rapamycin (mTOR; originally known as mammalian _target of rapamycin) is a central cell growth regulator connecting cellular metabolism and growth with a wide range of environmental inputs as part of mTOR complex 1 (mTORC1) and mTORC2. In this Review, we introduce the landmark discoveries in the mTOR field, starting from the isolation of rapamycin to the molecular characterizations of key components of the mTORC signalling network with an emphasis on amino acid sensing, and discuss the perspectives of mTORC inhibitors in therapeutic applications.

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References

1. Sabatini, D. M. Twenty-five years of mTOR: uncovering the link from nutrients to growth. Proc. Natl Acad. Sci. USA 114, 11818–11825 (2017). - PubMed
1. Vezina, C., Kudelski, A. & Sehgal, S. N. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. 28, 721–726 (1975). - PubMed
1. Baker, H., Sidorowicz, A., Sehgal, S. N. & Vezina, C. Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation. J. Antibiot. 31, 539–545 (1978). - PubMed
1. Douros, J. & Suffness, M. New antitumor substances of natural origin. Cancer Treat. Rev. 8, 63–87 (1981). - PubMed
1. Eng, C. P., Sehgal, S. N. & Vezina, C. Activity of rapamycin (AY-22,989) against transplanted tumors. J. Antibiot. 37, 1231–1237 (1984). - PubMed

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[1] Sabatini, D. M. Twenty-five years of mTOR: uncovering the link from nutrients to growth. Proc. Natl Acad. Sci. USA 114, 11818–11825 (2017). - PubMed

[2] Sabatini, D. M. Twenty-five years of mTOR: uncovering the link from nutrients to growth. Proc. Natl Acad. Sci. USA 114, 11818–11825 (2017). - PubMed

[3] Vezina, C., Kudelski, A. & Sehgal, S. N. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. 28, 721–726 (1975). - PubMed

[4] Vezina, C., Kudelski, A. & Sehgal, S. N. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. 28, 721–726 (1975). - PubMed

[5] Baker, H., Sidorowicz, A., Sehgal, S. N. & Vezina, C. Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation. J. Antibiot. 31, 539–545 (1978). - PubMed

[6] Baker, H., Sidorowicz, A., Sehgal, S. N. & Vezina, C. Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation. J. Antibiot. 31, 539–545 (1978). - PubMed

[7] Douros, J. & Suffness, M. New antitumor substances of natural origin. Cancer Treat. Rev. 8, 63–87 (1981). - PubMed

[8] Douros, J. & Suffness, M. New antitumor substances of natural origin. Cancer Treat. Rev. 8, 63–87 (1981). - PubMed

[9] Eng, C. P., Sehgal, S. N. & Vezina, C. Activity of rapamycin (AY-22,989) against transplanted tumors. J. Antibiot. 37, 1231–1237 (1984). - PubMed

[10] Eng, C. P., Sehgal, S. N. & Vezina, C. Activity of rapamycin (AY-22,989) against transplanted tumors. J. Antibiot. 37, 1231–1237 (1984). - PubMed

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mTOR as a central hub of nutrient signalling and cell growth

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mTOR as a central hub of nutrient signalling and cell growth

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