Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jan 1:141:105042.
doi: 10.1016/j.ejps.2019.105042. Epub 2019 Oct 18.

Development of a w/o emulsion using ionic liquid strategy for transdermal delivery of anti - aging component α - lipoic acid: Mechanism of different ionic liquids on skin retention and efficacy evaluation

Zhuang Zhou  1 , Chao Liu  1 , Xiaocao Wan  1 , Liang Fang  2
Affiliations

Development of a w/o emulsion using ionic liquid strategy for transdermal delivery of anti - aging component α - lipoic acid: Mechanism of different ionic liquids on skin retention and efficacy evaluation

Zhuang Zhou et al. Eur J Pharm Sci. .

Abstract

Skin aging affects personal image and health. α - lipoic acid (ALA), with excellent free radical scavenging capacity, was used in this research to prepare W/O emulsion. Considering the instability of ALA, ionic liquid strategy was adopted to heighten the solubility of ALA for dissolving in water phase. The mechanism of different ionic liquids (ILs) on skin retention of ALA was investigated by in vitro skin permeation experiment, emulsion quality characterization, rheological test, ATR - FTIR and molecular simulation. The results showed that ionic liquid strategy had a positive influence on the solubilization of ALA. Different ILs were different in skin retention and regulated by skin layers rather than drug release, in which ALA - triethanolamine (ALA - TEOA) presented the best affinity with both stratum corneum (SC) and viable epidermis and dermis (VED), while ALA - N - (2 - Hydroxyethyl) piperidine (ALA - HEPP) as well as ALA - N - (2 - hydroxyethyl) pyrrolidine (ALA - HEPR) showed affinity with either SC or VED respectively. Finally, the emulsion presented brilliant anti - aging efficacy. This study provided a new method of emulsion research and had great significance for the development of topical formulations.

Keywords: Anti – aging efficacy; Ionic liquids; Skin retention; Solubility; Α – lipoic acid.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles
  NODES
admin 3
twitter 2