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. 2020 Aug;166(8):717-726.
doi: 10.1099/mic.0.000930.

Anti-biofilm and anti-virulence effects of zerumbone against Acinetobacter baumannii

Hye-Rim Kim  1 , Da-Seul Shin  1 , Hye-In Jang  1 , Yong-Bin Eom  1   2
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Free article

Anti-biofilm and anti-virulence effects of zerumbone against Acinetobacter baumannii

Hye-Rim Kim et al. Microbiology (Reading). 2020 Aug.
Free article

Abstract

Acinetobacter baumannii is a multidrug-resistant opportunistic pathogen that affects patients with a compromised immune system and is becoming increasingly important as a hospital-derived infection. This pathogen is difficult to treat owing to its intrinsic multidrug resistance and ability to form antimicrobial-tolerant biofilms. In the present study, we aimed to assess the potential use of zerumbone as a novel anti-biofilm and/or anti-virulence agent against A. baumannii. The results showed that zerumbone at sub-inhibitory doses decreased biofilm formation and disrupted established A. baumannii biofilms. The zerumbone-induced decrease in biofilm formation was dose-dependent based on the results of microtitre plate biofilm assays and confocal laser scanning microscopy. In addition, our data validated the anti-virulence efficacy of zerumbone, wherein it significantly interfered with the motility of A. baumannii. To support these phenotypic results, transcriptional analysis revealed that zerumbone downregulated the expression of biofilm- and virulence-associated genes (adeA, adeB, adeC and bap) in A. baumannii. Overall, our findings suggested that zerumbone might be a promising bioactive agent for the treatment of biofilm- and virulence-related infections caused by multidrug-resistant A. baumannii.

Keywords: Acinetobacter baumannii; anti-biofilm; anti-virulence; biofilm-associated protein (Bap); resistance-nodulation-division (RND)-type efflux pump; zerumbone.

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