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Review
. 2020 Aug 14:7:12.
doi: 10.1186/s40673-020-00121-1. eCollection 2020.

Essential tremor: the most common form of cerebellar degeneration?

Elan D Louis  1 , Phyllis L Faust  2
Affiliations
Review

Essential tremor: the most common form of cerebellar degeneration?

Elan D Louis et al. Cerebellum Ataxias. .

Abstract

Background: The degenerative cerebellar ataxias comprise a large and heterogeneous group of neurological diseases whose hallmark clinical feature is ataxia, and which are accompanied, to variable degrees, by other features that are attributable to cerebellar dysfunction. Essential tremor (ET) is an exceptionally common neurological disease whose primary motor feature is action tremor, although patients often manifest intention tremor, mild gait ataxia and several other features of cerebellar dysfunction.

Main body: In this paper, we review the abundant evidence derived from clinical, neuroimaging and postmortem studies, linking ET to cerebellar dysfunction. Furthermore, we review the combination of clinical, natural history and postmortem features suggesting that ET is neurodegenerative. We then compare the prevalence of ET (400 - 900 cases per 100,000) to that of the other cerebellar degenerations (ranging from <0.5 - 9 cases per 100,000, and in composite likely to be on the order of 20 cases per 100,000) and conclude that ET is 20 to 45 times more prevalent than all other forms of cerebellar degeneration combined.

Conclusion: Given the data we present, it is logical to conclude that ET is, by far, the most common form of cerebellar degeneration.

Keywords: Essential tremor; cerebellar degeneration; cerebellum; neurodegeneration; prevalence; spinocerebellar ataxia.

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Conflict of interest statement

Competing interestsDr. Louis and Dr. Faust declare that they have no competing interests.

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References

    1. Paulson HL. The spinocerebellar ataxias. J Neuroophthalmol. 2009;29(3):227–237. - PMC - PubMed
    1. Koeppen AH. The neuropathology of the adult cerebellum. Handb Clin Neurol. 2018;154:129–149. - PMC - PubMed
    1. Manto M, Gandini J, Feil K, Strupp M. Cerebellar ataxias: an update. Curr Opin Neurol. 2020;33(1):150–160. - PubMed
    1. Meira AT, Arruda WO, Ono SE, Neto AC, Raskin S, Camargo CHF, et al. Neuroradiological Findings in the Spinocerebellar Ataxias. Tremor Other Hyperkinet Mov (N Y) 2019;9:10.7916/tohm.v0.682. - PMC - PubMed
    1. Soong BW, Morrison PJ. Spinocerebellar ataxias. Handb Clin Neurol. 2018;155:143–174. - PubMed

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