doi: 10.1126/science.7071590.
Calcium and age in fibroblasts from control subjects and patients with cystic fibrosis
- PMID: 7071590
- DOI: 10.1126/science.7071590
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Calcium and age in fibroblasts from control subjects and patients with cystic fibrosis
Science.
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Abstract
Intracellular calcium increases significantly as human fibroblasts age in culture. The calcium increase occurs 5 to 6 weeks (passages) earlier and is significantly greater in fibroblasts from subjects with cystic fibrosis in comparison with cells from control subjects. Intracellular calcium, which is thought to be a pathogenetic factor in cystic fibrosis, may also be a meaningful marker in cell aging.
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