HomeCurrent Issue
Current Issue
January 2024 - Volume 3 - 1
Research
20 December 2024•
Use of sodium valproate and other antiseizure drug treatments in England and Wales: quantitative analysis of nationwide linked electronic health recordsCaroline E Dale, Rohan Takhar, Yat Yi Fan, Fatemeh Torabi, Michail Katsoulis, Samuel Kim, Andrew Lambarth, Christopher Tomlinson, Tim Wilkinson, Tanja Mueller, Amanj Kurdi, Mark Ashworth, Mamas A Mamas, Kamlesh Khunti, Ashley Akbari, Andrew D Morris, Munir Pirmohamed, Anthony G Marson, David Williams, David Hunt, Cathie Sudlow, Reecha Sofat
12 December 2024•
Pregnant women admitted to hospital with covid-19 in 10 European countries: individual patient data meta-analysis of population based cohorts in International Obstetric Survey SystemsHilde Marie Engjom, Odette de Bruin, Rema Ramakrishnan, Anna J M Aabakke, Outi Äyräs, Catherine Deneux-Tharaux, Serena Donati, Marian Knight, Eva Jonasdottir, Teresia Svanvik, An Vercoutere, Nicola Vousden, Kitty WM Bloemenkamp
5 December 2024•
Vaccine effectiveness against mild and severe covid-19 in pregnant individuals and their infants in England: test negative case-control studyFreja C M Kirsebom, Nick Andrews, Anna A Mensah, Julia Stowe, Shamez Ladhani, Mary Ramsay, Jamie Lopez Bernal, Helen Julia Campbell
27 November 2024•
Caesarean section and risk of infection in offspring: systematic review and meta-analysis of observational studiesIsobel Masson Francis Todd, Maria Christine Magnus, Lars Henning Pedersen, David Burgner, Jessica Eden Miller
17 November 2024•
Comparative effectiveness of monovalent XBB.1.5 containing covid-19 mRNA vaccines in Denmark, Finland, and Sweden: _target trial emulation based on registry dataNiklas Worm Andersson, Emilia Myrup Thiesson, Nicklas Pihlström, Jori Perälä, Kristýna Faksová, Mie Agermose Gram, Eero Poukka, Tuija Leino, Rickard Ljung, Anders Hviid
12 November 2024•
Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control studyBarbara Iyen, Carol Coupland, Brian Gregory Bell, Darren M Ashcroft, Martin William Orrell, Delia Bishara, Tom Dening, Anthony J Avery
30 October 2024•
Characteristics of non-randomised studies of drug treatments: cross sectional studySally Yaacoub, Raphael Porcher, Anna Pellat, Hillary Bonnet, Viet-Thi Tran, Philippe Ravaud, Isabelle Boutron
12 November 2024•
Combinations of multiple long term conditions and risk of hospital admission or death during winter 2021-22 in England: population based cohort studyNazrul Islam, Sharmin Shabnam, Nusrat Khan, Clare Gillies, Francesco Zaccardi, Amitava Banerjee, Vahé Nafilyan, Kamlesh Khunti, Hajira Dambha-Miller
28 October 2024•
Proactive therapeutic drug monitoring of biologic drugs in patients with inflammatory bowel disease, inflammatory arthritis, and psoriasis: systematic review and meta-analysisDena Zeraatkar, Tyler Stacy Pitre, Sarah Kirsh, Tanvir Jassal, Michael Ling, Muizz Hussain, Rachel J Couban, Leticia Kawano-Dourado, Eirik K Kristianslund, Per Olav Vandvik
22 October 2024•
Human papillomavirus nonavalent (HPV9) vaccination and risk of immune mediated diseases, myocarditis, pericarditis, and thromboembolic outcomes in Denmark: self-controlled case series studyKristýna Faksová, Anna D Laksafoss, Anders Hviid
1 October 2024•
Sodium-glucose co-transporter-2 inhibitors in patients with chronic kidney disease with or without type 2 diabetes: systematic review and meta-analysisXinyu Zou, Qingyang Shi, Per Olav Vandvik, Yunhe Mao, Arnav Agarwal, Belen Ponte, Xiaoxi Zeng, Gordon Guyatt, Qinbo Yang, Xianghang Luo, Chang Xu, Ping Fu, Haoming Tian, Thomas Agoritsas, Sheyu Li
16 September 2024•
Association between maternal mRNA covid-19 vaccination in early pregnancy and major congenital anomalies in offspring: population based cohort study with sibling matched analysisSarah C J Jorgensen, Samantha S M Drover, Deshayne B Fell, Peter C Austin, Rohan D'Souza, Astrid Guttmann, Sarah A Buchan, Sarah E Wilson, Sharifa Nasreen, Kevin A Brown, Kevin L Schwartz, Mina Tadrous, Kumanan Wilson, Jeffrey C Kwong
17 August 2024•
Deep brain stimulation for Parkinson’s disease: systematic review with meta-analysis and trial sequential analysisJohanne Juul Petersen, Caroline Barkholt Kamp, Pascal Faltermeier, Sophie Juul, Annemette Løkkegaard, Christian Gluud, Janus C Jakobsen
17 August 2024•
Multimorbidity and adverse outcomes following emergency department attendance: population based cohort studyMichael C Blayney, Matthew J Reed, John A Masterson, Atul Anand, Matt M Bouamrane, Jacques Fleuriot, Saturnino Luz, Marcus J Lyall, Stewart Mercer, Nicholas L Mills, Susan D Shenkin, Timothy S Walsh, Sarah H Wild, Honghan Wu, Stela McLachlan, Bruce Guthrie, Nazir I Lone
17 August 2024•
All cause and cause specific mortality in 15-24-year-olds in Denmark 2010 to 2022: nationwide study of socioeconomic predictorsSofie Kruckow, Janne S Tolstrup
14 August 2024•
Development and validation of a prognostic model to predict birth weight: individual participant data meta-analysisJohn Allotey, Lucinda Archer, Kym I E Snell, Dyuti Coomar, Jacques Massé, Line Sletner, Hans Wolf, George Daskalakis, Shigeru Saito, Wessel Ganzevoort, Akihide Ohkuchi, Hema Mistry, Diane Farrar, Fionnuala Mone, Jun Zhang, Paul T Seed, Helena Teede, Fabricio Da Silva Costa, Athena P Souka, Melanie Smuk, Sergio Ferrazzani, Silvia Salvi, Federico Prefumo, Rinat Gabbay-Benziv, Chie Nagata, Satoru Takeda, Evan Sequeira, Olav Lapaire, Jose Guilherme Cecatti, Rachel Katherine Morris, Ahmet A Baschat, Kjell Salvesen, Luc Smits, Dewi Anggraini, Alice Rumbold, Marleen van Gelder, Arri Coomarasamy, John Kingdom, Seppo Heinonen, Asma Khalil, François Goffinet, Sadia Haqnawaz, Javier Zamora, Richard D Riley, Shakila Thangaratinam
12 August 2024•
Age and sex specific thresholds for risk stratification of cardiovascular disease and clinical decision making: prospective open cohort studyZhe Xu, Juliet Usher-Smith, Lisa Pennells, Ryan Chung, Matthew Arnold, Lois Kim, Stephen Kaptoge, Matthew Sperrin, Emanuele Di Angelantonio, Angela M Wood
11 July 2024•
Harnessing policy to promote inclusive medical product evidence: development of a reference standard and structured audit of clinical trial diversity policiesJennifer Miller, William Pelletiers, Sakinah Suttiratana, Michael Ofosu Mensah, Jason Schwartz, Reshma Ramachandran, Cary Gross, Joseph S Ross
24 May 2024•
Incidence and treatment of group A streptococcal infections during covid-19 pandemic and 2022 outbreak: retrospective cohort study in England using OpenSAFELY-TPPChristine Cunningham, Louis Fisher, Christopher Wood, Victoria Speed, Andrew D Brown, Helen Curtis, Rose Higgins, Richard Croker, Ben FC Butler-Cole, David Evans, Peter Inglesby, Iain Dillingham, Sebastian CJ Bacon, Elizabeth Beech, Kieran Hand, Simon Davy, Tom Ward, George Hickman, Lucy Bridges, Thomas O'Dwyer, Steven Maude, Rebecca M Smith, Amir Mehrkar, Liam C Hart, Chris Bates, Jonathan Cockburn, John Parry, Frank Hester, Sam Harper, Ben Goldacre, Brian MacKenna
15 May 2024•
Development of a national maternity early warning score: centile based score development and Delphi informed escalation pathwaysStephen Gerry, Jonathan Bedford, Oliver C Redfern, Hannah Rutter, Mae Chester-Jones, Marian Knight, Tony Kelly, Peter J Watkinson
3 May 2024•
Participant characteristics and exclusion from phase 3/4 industry funded trials of chronic medical conditions: meta-analysis of individual participant level dataJennifer Lees, Jamie Crowther, Peter Hanlon, Elaine W Butterly, Sarah H Wild, Frances Mair, Bruce Guthrie, Katie Gillies, Sofia Dias, Nicky J Welton, Srinivasa Vittal Katikireddi, David A McAllister
21 May 2024•
Regular use of fish oil supplements and course of cardiovascular diseases: prospective cohort studyGe Chen, Zhengmin (Min) Qian, Junguo Zhang, Shiyu Zhang, Zilong Zhang, Michael G Vaughn, Hannah E Aaron, Chuangshi Wang, Gregory YH Lip, Hualiang Lin
18 April 2024•
Identification of patients undergoing chronic kidney replacement therapy in primary and secondary care data: validation study based on OpenSAFELY and UK Renal RegistryShalini Santhakumaran, Louis Fisher, Bang Zheng, Viyaasan Mahalingasivam, Lucy Plumb, Edward PK Parker, Retha Steenkamp, Caroline Morton, Amir Mehrkar, Sebastian Bacon, Sue Lyon, Rob Konstant-Hambling, Ben Goldacre, Brian MacKenna, Laurie A Tomlinson, Dorothea Nitsch
5 April 2024•
Characterization of accelerated approval status, trial endpoints and results, and recommendations in guidelines for oncology drug treatments from the National Comprehensive Cancer Network: cross sectional studyMaryam Mooghali, Aaron P Mitchell, Joshua J Skydel, Joseph S Ross, Joshua D Wallach, Reshma Ramachandran
19 March 2024•
Preterm prelabour rupture of membranes before 23 weeks’ gestation: prospective observational studyLaura Goodfellow, Angharad Care, Ciara Curran, Devender Roberts, Mark A Turner, Marian Knight, Alfirevic Zarko
11 March 2024•
Socioeconomic inequalities in risk of infection with SARS-CoV-2 delta and omicron variants in the UK, 2020-22: analysis of the longitudinal COVID-19 Infection SurveyCameron Razieh, Sharmin Shabnam, Hajira Dambha-Miller, Eva J A Morris, Tom Yates, Yogini Chudasama, Francesco Zaccardi, Clare Gillies, Amitava Banerjee, Manish Pareek, Ben Lacey, Martin White, Kamlesh Khunti, Nazrul Islam
21 February 2024•
Effectiveness and cost effectiveness of pharmacological thromboprophylaxis for medical inpatients: decision analysis modelling studySarah Davis, Steve Goodacre, Daniel Horner, Abdullah Pandor, Mark Holland, Kerstin de Wit, Beverley J Hunt, Xavier Luke Griffin
17 February 2024•
ADNEX risk prediction model for diagnosis of ovarian cancer: systematic review and meta-analysis of external validation studiesLasai Barreñada, Ashleigh Ledger, Paula Dhiman, Gary Collins, Laure Wynants, Jan Y Verbakel, Dirk Timmerman, Lil Valentin, Ben Van Calster
13 February 2024•
Association of vaginal oestradiol and the rate of breast cancer in Denmark: registry based, case-control study, nested in a nationwide cohortAmani Meaidi, Nelsan Pourhadi, Ellen Christine Løkkegaard, Christian Torp-Pedersen, Lina Steinrud Mørch
13 February 2024•
Effect of timeframes to define long term conditions and sociodemographic factors on prevalence of multimorbidity using disease code frequency in primary care electronic health records: retrospective studyThomas Beaney, Jonathan Clarke, Thomas Woodcock, Azeem Majeed, Mauricio Barahona, Paul Aylin
10 February 2024•
Published research on the human health implications of climate change between 2012 and 2021: cross sectional studyVictoria L Bartlett, Harry Doernberg, Maryam Mooghali, Ravi Gupta, Joshua D Wallach, Kate Nyhan, Kai Chen, Joseph S Ross
7 February 2024•
Effect of a prepartum and postpartum, complex interdisciplinary lifestyle and psychosocial intervention on metabolic and mental health outcomes in women with gestational diabetes mellitus (the MySweetheart trial): randomised, single centred, blinded, controlled trialDan Yedu Quansah, Leah Gilbert, Amar Arhab, Elena Gonzalez-Rodriguez, Didier Hans, Justine Gross, Stefano Lanzi, Bobby Stuijfzand, Alain Lacroix, Antje Horsch, Jardena J Puder
5 February 2024•
Design differences and variation in results between randomised trials and non-randomised emulations: meta-analysis of RCT-DUPLICATE dataRachel Heyard, Leonhard Held, Sebastian Schneeweiss, Shirley V Wang
6 March 2024•
All cause and cause specific mortality associated with transition to daylight saving time in US: nationwide, time series, observational studyShi Zhao, Wangnan Cao, Gengze Liao, Zihao Guo, Lufei Xu, Chen Shen, Chun Chang, Xiao Liang, Kai Wang, Daihai He, Shengzhi Sun, Rui Chen, Francesca Dominici
29 January 2024•
Covid-19 pandemic and equity of global human papillomavirus vaccination: descriptive study of World Health Organization-Unicef vaccination coverage estimatesRebecca Mary Casey, Hiroki Akaba, Terri B Hyde, Paul Bloem
29 January 2024•
Post-covid-19 conditions in adults: systematic review and meta-analysis of health outcomes in controlled studiesJuan Victor Ariel Franco, Luis Ignacio Garegnani, Maria-Inti Metzendorf, Katharina Heldt, Rebekka Mumm, Christa Scheidt-Nave
11 January 2024•
Availability of results of clinical trials registered on EU Clinical Trials Register: cross sectional audit studyNicholas J DeVito, Jessica Morley, James Andrew Smith, Henry Drysdale, Ben Goldacre, Carl Heneghan
Specialist review
9 April 2024•
Neonatal hypoglycaemiaJane E Harding, Jane M Alsweiler, Taygen E Edwards, Chris JD McKinlay
29 March 2024•
New insights into understanding obesity: from measures to mechanismsNicholas J Timpson, Kaitlin H Wade, Madeleine L Smith, Lucy J Goudswaard, Naveed Sattar, Dimitri J Pournaras, Laura J Corbin
Editorial
12 November 2024•
Impact of multiple long term conditions on hospital admission and mortality during winter: importance of linked, population scale healthcare dataJonathan Adam Batty, Lesley Smith, Marlous Hall
28 October 2024•
Therapeutic drug monitoring for immune mediated inflammatory diseasesNeil Chanchlani, Zenas Z N Yiu, Lisa K Stamp, Andrew S Day
17 August 2024•
Progressive pulmonary fibrosis: a need for real world data to solve real world clinical problemsHuajian Liu, Kerri-Marie Heenan, Liam Coyle, Nazia Chaudhuri
17 August 2024•
Multimorbidity in emergency departments: urgent need for integrated careYouri Yordanov, Agathe Beauvais, Pierre-Clément Thiébaud
11 July 2024•
Fostering diversity in clinical trials: need for evidence and implementation to improve representationDavid Collister, Claire Song, Shannon M Ruzycki
3 April 2024•
Practical implications of the ADNEX risk prediction model for diagnosis of ovarian cancerSaketh Guntupalli
28 February 2024•
Multimorbidity research: where one size does not fit allAnna Head, Martin O'Flaherty, Chris Kypridemos
Opinion
12 April 2024•
To adjust or not to adjust: it is not the tests performed that count, but how they are reported and interpretedAnne-Laure Boulesteix, Sabine Hoffmann
Education
19 February 2024•
Machine learning in the assessment and management of acute gastrointestinal bleedingGaurav Bhaskar Nigam, Michael F Murphy, Simon P L Travis, Adrian J Stanley
Methods primer
30 May 2024•
Assessing the methodological quality and risk of bias of systematic reviews: primer for authors of overviews of systematic reviewsCarole Lunny, Salmaan Kanji, Pierre Thabet, Anna-Bettina Haidich, Konstantinos I Bougioukas, Dawid Pieper