Eritroblastopenija

Čista eritrocitna aplazija
Čista eritrocitna aplazija
Drugi nazivi	Eritroblastopenija, čista aplazija crvenih krvnih zrnaca
	Mikrografija krvnih ćelija pod skenirajućim elektronskim mikroskopom. S lijeva na desno: ljudska crvena krvna zrnca, trombocit i leukocit. Čista aplazija crvenih krvnih zrnaca posebno pogađa eritrocite
Specijalnost	Hematologija

Čista aplazija crvenih krvnih zrnaca (PRCA) ili eritroblastopenija odnosi se na tip aplazijske anemije koja utiče na prekursore crvenih krvnih zrnaca, ali obično ne na bijela krvna zrnca. U PRCA, koštana srž prestaje proizvoditi crvena krvna zrnca. Postoji više etiologija koje mogu uzrokovati PRCA. Stanje je prvi opisao Paul Kaznelson 1922. godine.^[1]

Znakovi i simptomi

Znakovi i simptomi mogu uključivati:

Uzroci

Uzroci PRCA uključuju:

Autoimunska bolest,
Timom.^[2]
Virusne infekcije kao što su HIV, virus herpes simpleks, parvovirus B19 (peta bolest),^[3] ili hepatitis.
Limfoproliferacija: Povezanost čiste aplazije crvenih krvnih zrnaca s T-ćelijskom leukemijom velikih granulastih limfocita je dobro poznata, posebno u Kini.^[4]
Idiopatija: Mnogi slučajevi PRCA smatraju se idiopatskim jer nije otkriven vidljiv uzrok.^[5]
Lijekovi kao što je mikofenolna kiselina^[6] ili eritropoetin.^[7]
Kongenitalni: Termin "nasljedna čista aplazija crvenih krvnih zrnaca" koristi se za označavanje Diamond–Blackfanove anemije.^[8]

Tretman

PRCA se smatra autoimunskom bolešću jer će kod mnogih pacijenata reagovati na imunosupresivno liječenje kao što je ciklosporinom,^[9] iako ovaj pristup nije bez rizika.^[10]

Također pogledajre

Reference

^ Kaznelson P (1922). "Zur Entstehung der Blutplättchen". Verh Dtsch Ges Inn Med. 34: 557–8.
^ Hirokawa M, Sawada K, Fujishima N, et al. (januar 2008). "Long-term response and outcome following immunosuppressive therapy in thymoma-associated pure red cell aplasia: a nationwide cohort study in Japan by the PRCA collaborative study group". Haematologica. 93 (1): 27–33. doi:10.3324/haematol.11655. PMID 18166782.
^ Geetha D, Zachary JB, Baldado HM, Kronz JD, Kraus ES (decembar 2000). "Pure red cell aplasia caused by Parvovirus B19 infection in solid organ transplant recipients: a case report and review of literature". Clinical Transplantation. 14 (6): 586–91. doi:10.1034/j.1399-0012.2000.140612.x. PMID 11127313.
^ Kwong YL, Wong KF (1998). "Association of pure red cell aplasia with T large granular lymphocyte leukaemia". J. Clin. Pathol. 51 (9): 672–5. doi:10.1136/jcp.51.9.672. PMC 500904. PMID 9930071.
^ Miller AC, Rashid RM (2008). "Three episodes of acquired pure red cell aplasia restricted to pregnancy". Journal of Perinatal Medicine. 36 (3): 270–1. doi:10.1515/JPM.2008.041. PMID 18576941.
^ Petrochko C (2009). "FDA Strengthens Warning on Transplant Drug." Medpage Today. 14 August 2009. Accessed 19 August 2009.
^ Macdougall, IC (novembar 2007). "Epoetin-induced pure red cell aplasia: diagnosis and treatment". Current Opinion in Nephrology and Hypertension. 16 (6): 585–8. doi:10.1097/MNH.0b013e3282f0c4bf. PMID 18089975.
^ OMIM: 105650
^ Sawada K, Hirokawa M, Fujishima N, et al. (august 2007). "Long-term outcome of patients with acquired primary idiopathic pure red cell aplasia receiving cyclosporine A. A nationwide cohort study in Japan for the PRCA Collaborative Study Group". Haematologica. 92 (8): 1021–8. doi:10.3324/haematol.11192. PMID 17640861.
^ Sawada K, Fujishima N, Hirokawa M (august 2008). "Acquired pure red cell aplasia: updated review of treatment". Br. J. Haematol. 142 (4): 505–14. doi:10.1111/j.1365-2141.2008.07216.x. PMC 2592349. PMID 18510682.

Vanjski linkovi

[1] Kaznelson P (1922). "Zur Entstehung der Blutplättchen". Verh Dtsch Ges Inn Med. 34: 557–8.

[pmid18166782-2] Hirokawa M, Sawada K, Fujishima N, et al. (januar 2008). "Long-term response and outcome following immunosuppressive therapy in thymoma-associated pure red cell aplasia: a nationwide cohort study in Japan by the PRCA collaborative study group". Haematologica. 93 (1): 27–33. doi:10.3324/haematol.11655. PMID 18166782.

[pmid11127313-3] Geetha D, Zachary JB, Baldado HM, Kronz JD, Kraus ES (decembar 2000). "Pure red cell aplasia caused by Parvovirus B19 infection in solid organ transplant recipients: a case report and review of literature". Clinical Transplantation. 14 (6): 586–91. doi:10.1034/j.1399-0012.2000.140612.x. PMID 11127313.

[4] Kwong YL, Wong KF (1998). "Association of pure red cell aplasia with T large granular lymphocyte leukaemia". J. Clin. Pathol. 51 (9): 672–5. doi:10.1136/jcp.51.9.672. PMC 500904. PMID 9930071.

[5] Miller AC, Rashid RM (2008). "Three episodes of acquired pure red cell aplasia restricted to pregnancy". Journal of Perinatal Medicine. 36 (3): 270–1. doi:10.1515/JPM.2008.041. PMID 18576941.

[6] Petrochko C (2009). "FDA Strengthens Warning on Transplant Drug." Medpage Today. 14 August 2009. Accessed 19 August 2009.

[7] Macdougall, IC (novembar 2007). "Epoetin-induced pure red cell aplasia: diagnosis and treatment". Current Opinion in Nephrology and Hypertension. 16 (6): 585–8. doi:10.1097/MNH.0b013e3282f0c4bf. PMID 18089975.

[8] OMIM: 105650

[pmid17640861-9] Sawada K, Hirokawa M, Fujishima N, et al. (august 2007). "Long-term outcome of patients with acquired primary idiopathic pure red cell aplasia receiving cyclosporine A. A nationwide cohort study in Japan for the PRCA Collaborative Study Group". Haematologica. 92 (8): 1021–8. doi:10.3324/haematol.11192. PMID 17640861.

[pmid18510682-10] Sawada K, Fujishima N, Hirokawa M (august 2008). "Acquired pure red cell aplasia: updated review of treatment". Br. J. Haematol. 142 (4): 505–14. doi:10.1111/j.1365-2141.2008.07216.x. PMC 2592349. PMID 18510682.

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