LYPLA3

LYPLA3
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4X90, 4X91, 4X92, 4X93, 4X94, 4X95, 4X97
Identifikatori
Aliasi	PLA2G15
Vanjski ID-jevi	OMIM: 609362 MGI: 2178076 HomoloGene: 8200 GeneCards: PLA2G15
Lokacija gena (čovjek)
Hrom.	Hromosom 16 (čovjek)
Kraj	68,261,058 bp
Lokacija gena (miš)
Hrom.	Hromosom 8 (miš)
Kraj	106,891,347 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • O-acyltransferase activity; • lysophospholipase activity; • acyltransferase activity; • hydrolase activity; • phospholipid binding; • calcium-independent phospholipase A2 activity;
Ćelijska komponenta	• membrana; • mitohondrija; • Lizozom; • Egzosom; • Vanćelijsko; • nukleoplazma; • intracellular membrane-bounded organelle; • extracellular region;
Biološki proces	• fatty acid catabolic process; • phosphatidylcholine catabolic process; • ceramide metabolic process; • lipid metabolism; • fatty acid metabolic process; • lipid catabolic process; • phosphatidylethanolamine catabolic process; • glycerophospholipid metabolic process; • phosphatidylcholine metabolic process; • phospholipid metabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	23659
	192654
	ENSG00000103066
	ENSMUSG00000031903
	Q8NCC3
	Q8VEB4
	NM_012320; NM_001363551
	NM_133792; NM_001357319
	NP_036452; NP_001350480
	NP_598553; NP_001344248
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Fosfolipaza A2 grupe XV je enzim koji je kod ljudi kodiran genom PLA2G15.^[5]^[6]^[7]

Lizofosfolipaze su enzimi koji djeluju na biološke membrane, kako bi regulirali multifunkcionalne lizofosfolipide. Protein kodiran ovim genom hidrolizira lizofosfatidilholin u glicerofosforilholin i slobodnu masnu kiselinu. Ovaj enzim je prisutan u plazmi i smatra se da je povezan sa lipoproteinom velike gustoćee. Kasniji članak proturječi funkciji ovog gena. Dokazuje da ovaj gen kodira lizosomski enzim umjesto lizofosfolipaze i da ima i kalcij neovisnu fosfolipazu A2 i transakcilazne aktivnosti.^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 412 aminokiselina, a molekulska težina 46.658 Da.^[8]

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin

Q: Glutamin

R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MGLHLRPYRV	GLLPDGLLFL	LLLLMLLADP	ALPAGRHPPV	VLVPGDLGNQ
LEAKLDKPTV	VHYLCSKKTE	SYFTIWLNLE	LLLPVIIDCW	IDNIRLVYNK
TSRATQFPDG	VDVRVPGFGK	TFSLEFLDPS	KSSVGSYFHT	MVESLVGWGY
TRGEDVRGAP	YDWRRAPNEN	GPYFLALREM	IEEMYQLYGG	PVVLVAHSMG
NMYTLYFLQR	QPQAWKDKYI	RAFVSLGAPW	GGVAKTLRVL	ASGDNNRIPV
IGPLKIREQQ	RSAVSTSWLL	PYNYTWSPEK	VFVQTPTINY	TLRDYRKFFQ
DIGFEDGWLM	RQDTEGLVEA	TMPPGVQLHC	LYGTGVPTPD	SFYYESFPDR
DPKICFGDGD	GTVNLKSALQ	CQAWQSRQEH	QVLLQELPGS	EHIEMLANAT
TLAYLKRVLL	GP

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103066 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031903 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M (maj 1999). "Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase". Biochem Biophys Res Commun. 257 (1): 50–6. doi:10.1006/bbrc.1999.0411. PMID 10092508.
^ Schaloske RH, Dennis EA (Nov 2006). "The phospholipase A2 superfamily and its group numbering system". Biochim Biophys Acta. 1761 (11): 1246–59. doi:10.1016/j.bbalip.2006.07.011. PMID 16973413.
^ ^a ^b "Entrez Gene: LYPLA3 lysophospholipase 3 (lysosomal phospholipase A2)".
^ "UniProt, Q8NCC3". Pristupljeno 7. 7. 2021.

Dopunska literatura

Wang A, Dennis EA (1999). "Mammalian lysophospholipases". Biochim. Biophys. Acta. 1439 (1): 1–16. doi:10.1016/s1388-1981(99)00063-3. PMID 10395961.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Ohta T, Michel JJ, Schottelius AJ, Xiong Y (1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell. 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. PMID 10230407.
Hiraoka M, Abe A, Shayman JA (2002). "Cloning and characterization of a lysosomal phospholipase A2, 1-O-acylceramide synthase". J. Biol. Chem. 277 (12): 10090–9. doi:10.1074/jbc.M111977200. PMID 11790796.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Abe A, Poucher HK, Hiraoka M, Shayman JA (2004). "Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells". J. Lipid Res. 45 (4): 667–73. doi:10.1194/jlr.M300342-JLR200. PMID 14754907.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103066 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031903 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10092508-5] Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M (maj 1999). "Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase". Biochem Biophys Res Commun. 257 (1): 50–6. doi:10.1006/bbrc.1999.0411. PMID 10092508.

[pmid16973413-6] Schaloske RH, Dennis EA (Nov 2006). "The phospholipase A2 superfamily and its group numbering system". Biochim Biophys Acta. 1761 (11): 1246–59. doi:10.1016/j.bbalip.2006.07.011. PMID 16973413.

[entrez-7] "Entrez Gene: LYPLA3 lysophospholipase 3 (lysosomal phospholipase A2)".

[UniProt-8] "UniProt, Q8NCC3". Pristupljeno 7. 7. 2021.

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