NUDT4

NUDT4
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2DUK
Identifikatori
Aliasi	NUDT4
Vanjski ID-jevi	OMIM: 609229 MGI: 1918457 HomoloGene: 41726 GeneCards: NUDT4
Lokacija gena (čovjek)
Hrom.	Hromosom 12 (čovjek)
Kraj	93,408,146 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	95,400,008 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• inositol diphosphate tetrakisphosphate diphosphatase activity; • inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity; • inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; • inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity; • vezivanje iona metala; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje sa RNK; • inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity; • hydrolase activity; • diphosphoinositol-polyphosphate diphosphatase activity; • inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity; • inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; • inositol diphosphate pentakisphosphate diphosphatase activity; • inositol bisdiphosphate tetrakisphosphate diphosphatase activity; • endopolyphosphatase activity; • bis(5'-adenosyl)-hexaphosphatase activity; • bis(5'-adenosyl)-pentaphosphatase activity; • m7G(5')pppN diphosphatase activity; • snoRNA binding;
Ćelijska komponenta	• intracellular anatomical structure; • jedro; • citoplazma; • citosol;
Biološki proces	• GO:0007243 intracellular signal transduction; • cyclic nucleotide metabolic process; • inositol phosphate metabolic process; • cyclic-nucleotide-mediated signaling; • calcium-mediated signaling; • diphosphoinositol polyphosphate metabolic process; • diadenosine pentaphosphate catabolic process; • diadenosine hexaphosphate catabolic process; • adenosine 5'-(hexahydrogen pentaphosphate) catabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	11163
	71207
	ENSG00000173598
	ENSMUSG00000020029
	Q9NZJ9
	Q8R2U6
	NM_001301022; NM_001301023; NM_001301024; NM_019094; NM_199040
	NM_027722; NM_001358996
	NP_001287951; NP_001287952; NP_001287953; NP_061967; NP_950241
	NP_081998; NP_001345925
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Difosfoinozitol polifosfat-fosfohidrolaza 2 je enzim koji je kod ljudi kodiran genom NUDT4.^[5]^[6]^[7]

Protein kodiran ovim genom regulira promet polifosfat-difosfoinozitola. Promet ovih visokoenergetskih difosfoinozitol-polifosfata predstavlja aktivnost promjene molekula sa važnim regulatornim posljedicama. Molekulskno prebacivanje difosfoinozitol-polifosfata može doprinijeti regulaciji unutarčelijskog prometa. Opisano je nekoliko alternativno prerađenih varijanti transkripta, ali priroda nekih od njih nije utvrđena cijelom dužinom. Izoforme DIPP2alfa i DIPP2beta međusobno se razlikuju samo po tome što DIPP2beta ima jednu dodatnu aminokiselinu zbog pomjeranja granice introna u alternativnoj preradi.^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 180 aminokiselina, a molekulska težina 20.306 Da.^[8].

10	20	30	40	50
MMKFKPNQTR	TYDREGFKKR	AACLCFRSEQ	EDEVLLVSSS	RYPDQWIVPG
GGMEPEEEPG	GAAVREVYEE	AGVKGKLGRL	LGIFENQDRK	HRTYVYVLTV
TEILEDWEDS	VNIGRKREWF	KVEDAIKVLQ	CHKPVHAEYL	EKLKLGCSPA
NGNSTVPSLP	DNNALFVTAA	QTSGLPSSVR

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173598 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020029 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Caffrey JJ, Safrany ST, Yang X, Shears SB (Jun 2000). "Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family". J Biol Chem. 275 (17): 12730–6. doi:10.1074/jbc.275.17.12730. PMID 10777568.
^ Caffrey JJ, Shears SB (maj 2001). "Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2". Gene. 269 (1–2): 53–60. doi:10.1016/S0378-1119(01)00446-2. PMID 11376937.
^ ^a ^b "Entrez Gene: NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4".
^ "UniProt, Q9NZJ9". Pristupljeno 12. 8. 2021.

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
Leslie NR, McLennan AG, Safrany ST (2002). "Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases". BMC Biochem. 3: 20. doi:10.1186/1471-2091-3-20. PMC 117780. PMID 12121577.
Fisher DI, Safrany ST, Strike P, et al. (2003). "Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate". J. Biol. Chem. 277 (49): 47313–7. doi:10.1074/jbc.M209795200. PMID 12370170.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution". PLOS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173598 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020029 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10777568-5] Caffrey JJ, Safrany ST, Yang X, Shears SB (Jun 2000). "Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family". J Biol Chem. 275 (17): 12730–6. doi:10.1074/jbc.275.17.12730. PMID 10777568.

[pmid11376937-6] Caffrey JJ, Shears SB (maj 2001). "Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2". Gene. 269 (1–2): 53–60. doi:10.1016/S0378-1119(01)00446-2. PMID 11376937.

[entrez-7] "Entrez Gene: NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4".

[UniProt-8] "UniProt, Q9NZJ9". Pristupljeno 12. 8. 2021.

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