ELF1

E74-liki faktor 1 (transkripcijski faktor ETS-domena) je protein koji je kod ljudi kodiran genom ELF1.

ELF1
Identifikatori
Aliasi	ELF1
Vanjski ID-jevi	OMIM: 189973 MGI: 107180 HomoloGene: 7303 GeneCards: ELF1
Lokacija gena (čovjek) Hrom. Hromosom 13 (čovjek) Bend 13q14.11 Početak 40,931,924 bp Kraj 41,061,440 bp
Lokacija gena (miš) Hrom. Hromosom 14 (miš) Bend 14|14 D3 Početak 79,718,634 bp Kraj 79,819,934 bp
Ontologija gena Molekularna funkcija • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • vezivanje sa DNK • sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948, GO:0016582 vezivanje za proteine • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • jedro • nukleoplazma Biološki proces • GO:0032657 regulation of cytokine production • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • Ćelijska diferencijacija • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of T cell receptor signaling pathway • transcription by RNA polymerase II • regulation of cytokine-mediated signaling pathway • regulation of B cell receptor signaling pathway • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	1997	13709
Ensembl	ENSG00000120690	ENSMUSG00000036461
UniProt	P32519	Q60775
RefSeq (mRNK)	NM_001145353 NM_172373 NM_001370329 NM_001370330 NM_001370331 NM_001370332	NM_001286411 NM_001286412 NM_007920
RefSeq (bjelančevina)	NP_001138825 NP_758961 NP_001357258 NP_001357259 NP_001357260 NP_001357261	NP_001273340 NP_001273341 NP_031946
Lokacija (UCSC)	Chr 13: 40.93 – 41.06 Mb	Chr 14: 79.72 – 79.82 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 619 aminokiselina, a molekulska težina 67.498 Da.

10		20		30		40		50
MAAVVQQNDL		VFEFASNVME		DERQLGDPAI		FPAVIVEHVP		GADILNSYAG
LACVEEPNDM		ITESSLDVAE		EEIIDDDDDD		ITLTVEASCH		DGDETIETIE
AAEALLNMDS		PGPMLDEKRI		NNNIFSSPED		DMVVAPVTHV		SVTLDGIPEV
METQQVQEKY		ADSPGASSPE		QPKRKKGRKT		KPPRPDSPAT		TPNISVKKKN
KDGKGNTIYL		WEFLLALLQD		KATCPKYIKW		TQREKGIFKL		VDSKAVSRLW
GKHKNKPDMN		YETMGRALRY		YYQRGILAKV		EGQRLVYQFK		EMPKDLIYIN
DEDPSSSIES		SDPSLSSSAT		SNRNQTSRSR		VSSSPGVKGG		ATTVLKPGNS
KAAKPKDPVE		VAQPSEVLRT		VQPTQSPYPT		QLFRTVHVVQ		PVQAVPEGEA
ARTSTMQDET		LNSSVQSIRT		IQAPTQVPVV		VSPRNQQLHT		VTLQTVPLTT
VIASTDPSAG		TGSQKFILQA		IPSSQPMTVL		KENVMLQSQK		AGSPPSIVLG
PAQVQQVLTS		NVQTICNGTV		SVASSPSFSA		TAPVVTFSPR		SSQLVAHPPG
TVITSVIKTQ		ETKTLTQEVE		KKESEDHLKE		NTEKTEQQPQ		PYVMVVSSSN
GFTSQVAMKQ		NELLEPNSF

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Funkcija

Ovaj gen kodira faktor transkripcije specifičan za transformaciju E26. Kodirani protein primarno se eksprimira u limfoidnim ćelijamama i može djelovati i kao pojačivač i kao potiskivač za regulaciju transkripcije različitih gena. Alternativno prerađivanje rezultira u više varijanti transkripta.

Dopunaka literatura

• Xiang P, Lo C, Argiropoulos B, Lai CB, Rouhi A, Imren S, Jiang X, Mager D, Humphries RK (Sep 2010). "Identification of E74-like factor 1 (ELF1) as a transcriptional regulator of the Hox cofactor MEIS1". Experimental Hematology. 38 (9): 798–8, 808.e1-2. doi:10.1016/j.exphem.2010.06.006. PMC 3887005. PMID 20600580.
• Juang YT, Solomou EE, Rellahan B, Tsokos GC (Mar 2002). "Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR zeta-chain". Journal of Immunology. 168 (6): 2865–71. doi:10.4049/jimmunol.168.6.2865. PMID 11884456.
• Mao S, Frank RC, Zhang J, Miyazaki Y, Nimer SD (maj 1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias". Molecular and Cellular Biology. 19 (5): 3635–44. doi:10.1128/mcb.19.5.3635. PMC 84165. PMID 10207087.
• Nishiyama C, Takahashi K, Nishiyama M, Okumura K, Ra C, Ohtake Y, Yokota T (Dec 2000). "Splice isoforms of transcription factor Elf-1 affecting its regulatory function in transcription-molecular cloning of rat Elf-1". Bioscience, Biotechnology, and Biochemistry. 64 (12): 2601–7. doi:10.1271/bbb.64.2601. PMID 11210123.
• Thompson CB, Wang CY, Ho IC, Bohjanen PR, Petryniak B, June CH, Miesfeldt S, Zhang L, Nabel GJ, Karpinski B (Mar 1992). "cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1". Molecular and Cellular Biology. 12 (3): 1043–53. doi:10.1128/mcb.12.3.1043. PMC 369536. PMID 1545787.
• Tsokos GC, Nambiar MP, Juang YT (Apr 2003). "Activation of the Ets transcription factor Elf-1 requires phosphorylation and glycosylation: defective expression of activated Elf-1 is involved in the decreased TCR zeta chain gene expression in patients with systemic lupus erythematosus". Annals of the New York Academy of Sciences. 987: 240–5. doi:10.1111/j.1749-6632.2003.tb06054.x. PMID 12727645.
• Gunther M, Laithier M, Brison O (Jul 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Molecular and Cellular Biochemistry. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766. S2CID 1339642.
• Yang W, Tang H, Zhang Y, Tang X, Zhang J, Sun L, et al. (Jan 2013). "Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians". American Journal of Human Genetics. 92 (1): 41–51. doi:10.1016/j.ajhg.2012.11.018. PMC 3542470. PMID 23273568.
• Bassuk AG, Anandappa RT, Leiden JM (maj 1997). "Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells". Journal of Virology. 71 (5): 3563–73. doi:10.1128/JVI.71.5.3563-3573.1997. PMC 191503. PMID 9094628.