Protein GOT1B vezikulskog transporta je protein koji je kod ljudi kodiran genom GOLT1B .[ 5] [ 6] [ 7]
Got1p je protein koji pomaže u transportu vezikula kroz Golgijev aparat ćelije.[ 8] Homolozi proteina pronađeni su u Caenorhabditis elegans Plasmodium falciparum GOT1 je obično blisko povezan sa Sf2p (kodiran sa sft2), koji je još jedan protein slične funkcije. In vivo endosom -Golgijev aparat i ER -Golgijev aparat . In vitro got 1, posebno, rezultira defektom u transportu ER-Golgijev aparat, u odnosu na vezanje vezikula na Golgijeve membrane. Tačan doprinos proteina vezivanju vezikula je još uvijek misterija; međutim, sumnja se da je Got1p uključen u oslobađanje Ca2+ u Golgijevoj membrani, uzrokujući uticaj ionskih kanala povezanih s vezivanjem vezikula.[ 9]
Aminokiselinska sekvenca
uredi
^ a b c GRCh38: Ensembl release 89: ENSG00000111711 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030245 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Bourdon V, Naef F, Rao PH, Reuter V, Mok SC, Bosl GJ, Koul S, Murty VV, Kucherlapati RS, Chaganti RS (Nov 2002). "Genomic and expression analysis of the 12p11-p12 amplicon using EST arrays identifies two novel amplified and overexpressed genes". Cancer Res . 62 (21): 6218–23. PMID 12414650 . ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics" . Genome Res . 10 (5): 703–713. doi :10.1101/gr.10.5.703 . PMC 310876 PMID 10810093 . ^ "Entrez Gene: GOLT1B golgi transport 1 homolog B (S. cerevisiae)" .^ Connerly, PL (2010). "How Do Proteins Move Through the Golgi Apparatus?" . Nature Education . 3 (9): 60. ^ Conchon S, Cao X, Barlowe C, Pelham HR (juli 1999). "Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex" . The EMBO Journal . 18 (14): 3934–46. doi :10.1093/emboj/18.14.3934 . PMC 1171469 PMID 10406798 . ^ "UniProt, Q9Y3E0" . Pristupljeno 10. 8. 2021 .
Dopunska literatura
uredi
Conchon S, Cao X, Barlowe C, Pelham HR (juli 1999). "Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex" . The EMBO Journal . 18 (14): 3934–46. doi :10.1093/emboj/18.14.3934 . PMC 1171469 PMID 10406798 . Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (mart 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Research . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (septembar 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Reports . 1 (3): 287–92. doi :10.1093/embo-reports/kvd058 . PMC 1083732 PMID 11256614 . Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (maj 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways" . Oncogene . 22 (21): 3307–18. doi :10.1038/sj.onc.1206406 PMID 12761501 . Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (oktobar 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Research . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . 
