Katepsin L2

CTSV
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1FH0, 3H6S, 3KFQ
Identifikatori
Aliasi	CTSV, katepsin L2, katepsin V, CATL2, CTSL2, CTSU
Vanjski ID-jevi	OMIM: 603308 MGI: 88564 HomoloGene: 76699 GeneCards: CTSV
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	97,156,556 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	64,518,704 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• cysteine-type peptidase activity; • peptide binding; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • aminopeptidase activity; • hydrolase activity; • serine-type endopeptidase activity; • cysteine-type endopeptidase activity; • cysteine-type carboxypeptidase activity; • GO:0031493 histone binding; • kininogen binding; • GO:0032403 protein-containing complex binding;
Ćelijska komponenta	• citoplazma; • perikaryon; • apical part of cell; • secretory granule; • extracellular region; • microvillus; • Vakuola; • lysosomal lumen; • neuron projection; • Lizozom; • external side of plasma membrane; • Vanćelijsko; • jedro; • Jedarce; • GO:0016023 citoplazmatska vezikula;
Biološki proces	• male gonad development; • GO:1904578 response to organic cyclic compound; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • cellular response to starvation; • extracellular matrix disassembly; • response to glucocorticoid; • response to glucose; • Sertoli cell differentiation; • response to gonadotropin; • Proteoliza; • cell communication; • decidualization; • Spermatogeneza; • multicellular organism aging; • proteolysis involved in cellular protein catabolic process; • nerve development; • autophagic cell death; • response to odorant; • regulation of keratinocyte differentiation; • negative regulation of keratinocyte proliferation; • protein processing; • protein autoprocessing; • hair follicle morphogenesis; • regulation of actin cytoskeleton reorganization;
	Izvori:Amigo / QuickGO
Ortolozi
	1515
	13039
	ENSG00000136943
	ENSMUSG00000021477
	O60911
	P06797
	NM_001333; NM_001201575
	NM_009984
	NP_001188504; NP_001324
	NP_034114
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Katepsin L2, poznat i kao katepsin V je genetički kodiran sa lokusa gena CTSL2. Ovaj protein i gen koji ga kontrolira su specifičnoat čovjeka.^[5]

Protein koji je kodiran ovim genom je član proteinske porodice peptidaza, porodica C1. To je lizosomna cistein proteinaza koja može imati važnu ulogu u fiziologiji rožnjaće.

Ovaj gen se ispoljava kod bolesnika sa karcinomima debelo crijevo i dojke, crijeva, mliječnih žlijezda ili peritumorskih tkiva. To sugerira moguću ulogu ovog gena tumorskim procesima.^[6]^[7] ^[8]^[9]

Klinički značaj

Katepsin L2 može imati određenu ulogu u patogenezi keratokonusa.^[10]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136943 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021477 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CTSL2 cathepsin L2".
^ Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-1-8.
^ Hadžiselimović R., Pojskić N. (2005): Uvod u humanu imunogenetiku. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-3-4.
^ Hadžiselimović R. (1986): Uvod u teoriju antropogeneze. Svjetlost, Sarajevo, ISBN 9958-9344-2-6.
^ Kapur Pojskić L., Ed. (2014): Uvod u genetičko inženjerstvo i biotehnologiju, 2. izdanje. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 978-9958-9344-8-3.
^ Kenney, M. C.; Chwa, M.; Atilano, S. R.; Tran, A.; Carballo, M.; Saghizadeh, M.; Vasiliou, V.; Adachi, W.; Brown, D. J. (2005) Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder. Invest. Ophthal. Vis. Sci. 46: 823-832. PMID 15728537

Vanjski linkovi

Commons logo

Commons ima datoteke na temu: Katepsin L2

Commons logo

Commons ima datoteke na temu: Katepsin L2

MEROPS online database for peptidases and their inhibitors: C01.009 Arhivirano 22. 2. 2021. na Wayback Machine

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136943 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021477 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CTSL2 cathepsin L2".

[6] Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-1-8.

[7] Hadžiselimović R., Pojskić N. (2005): Uvod u humanu imunogenetiku. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-3-4.

[8] Hadžiselimović R. (1986): Uvod u teoriju antropogeneze. Svjetlost, Sarajevo, ISBN 9958-9344-2-6.

[9] Kapur Pojskić L., Ed. (2014): Uvod u genetičko inženjerstvo i biotehnologiju, 2. izdanje. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 978-9958-9344-8-3.

[Kenney05-10] Kenney, M. C.; Chwa, M.; Atilano, S. R.; Tran, A.; Carballo, M.; Saghizadeh, M.; Vasiliou, V.; Adachi, W.; Brown, D. J. (2005) Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder. Invest. Ophthal. Vis. Sci. 46: 823-832. PMID 15728537

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