SLC9B2

SLC9B2
Identifikatori
Aliasi	SLC9B2
Vanjski ID-jevi	OMIM: 611789 MGI: 2140077 HomoloGene: 45381 GeneCards: SLC9B2
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	103,085,829 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	135,051,148 bp
Ontologija gena
Molekularna funkcija	• solute:proton antiporter activity; • antiporter activity; • monovalent cation:proton antiporter activity; • lithium:proton antiporter activity; • sodium:proton antiporter activity; • vezivanje identičnih proteina;
Ćelijska komponenta	• integral component of membrane; • membrana; • mitohondrija; • mitochondrial inner membrane; • endosome membrane; • basolateral plasma membrane; • synaptic vesicle membrane; • sperm principal piece; • ćelijska membrana; • mitochondrial membranes; • intracellular vesicle; • endozom; • apical plasma membrane; • međućelijske veze; • GO:0016023 citoplazmatska vezikula; • projekcija ćelije; • sinapsa; • Treplja; • motile cilium;
Biološki proces	• proton transmembrane transport; • ion transmembrane transport; • cation transport; • ion transport; • positive regulation of osteoclast development; • transmembrane transport; • flagellated sperm motility; • sodium ion transmembrane transport; • regulation of insulin secretion involved in cellular response to glucose stimulus; • clathrin-dependent endocytosis; • sodium ion transport;
	Izvori:Amigo / QuickGO
Ortolozi
	133308
	97086
	ENSG00000164038
	ENSMUSG00000037994
	Q86UD5
	Q5BKR2
	NM_001300754; NM_001300756; NM_178833
	NM_178877
NP_001287683; NP_001287685; NP_849155; NP_001357128; NP_001357129;
	NP_001357130; NP_001357131; NP_001357132; NP_001357133; NP_001357134; NP_001357135; NP_001357136
	NP_849208
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Član 2 potporodice B porodice rastvornih nosača 9 (NHA2, katioski protonski antiporter 2), jest protein koji je kod ljudi kodiran genom SLC9B2 sa hromosoma 4.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 537 aminokiselina, а molekulska težina 57.564 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGDEDKRITY	EDSEPSTGMN	YTPSMHQEAQ	EETVMKLKGI	DANEPTEGSI
LLKSSEKKLQ	ETPTEANHVQ	RLRQMLACPP	HGLLDRVITN	VTIIVLLWAV
VWSITGSECL	PGGNLFGIII	LFYCAIIGGK	LLGLIKLPTL	PPLPSLLGML
LAGFLIRNIP	VINDNVQIKH	KWSSSLRSIA	LSIILVRAGL	GLDSKALKKL
KGVCVRLSMG	PCIVEACTSA	LLAHYLLGLP	WQWGFILGFV	LGAVSPAVVV
PSMLLLQGGG	YGVEKGVPTL	LMAAGSFDDI	LAITGFNTCL	GIAFSTGSTV
FNVLRGVLEV	VIGVATGSVL	GFFIQYFPSR	DQDKLVCKRT	FLVLGLSVLA
VFSSVHFGFP	GSGGLCTLVM	AFLAGMGWTS	EKAEVEKIIA	VAWDIFQPLL
FGLIGAEVSI	ASLRPETVGL	CVATVGIAVL	IRILTTFLMV	CFAGFNLKEK
IFISFAWLPK	ATVQAAIGSV	ALDTARSHGE	KQLEDYGMDV	LTVAFLSILI
TAPIGSLLIG	LLGPRLLQKV	EHQNKDEEVQ	GETSVQV

Funkcija

Natrij-vodikovi antiporteri, kao što je NHEDC2, pretvaraju protonsku pokretačku silu koju uspostavlja respiratorni lanac ili mitohondrijska F1F0 ATPaza u gradijente natrija koji pokreću druge procese. Oni zahtijevaju energiju, pretvaraju signale okoline u ćelijske odgovore ili funkciju u efluksu lijeka.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164038 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037994 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2".
^ "UniProt, Q86UD5" (jezik: engleski). Pristupljeno 30. 10. 2017.
^ Xiang M, Feng M, Muend S, Rao R (novembar 2007). "A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension". Proceedings of the National Academy of Sciences of the United States of America. 104 (47): 18677–81. Bibcode:2007PNAS..10418677X. doi:10.1073/pnas.0707120104. PMC 2141836. PMID 18000046.

Dopunska literatura

Kondapalli KC, Kallay LM, Muszelik M, Rao R (oktobar 2012). "Unconventional chemiosmotic coupling of NHA2, a mammalian Na+/H+ antiporter, to a plasma membrane H+ gradient". The Journal of Biological Chemistry. 287 (43): 36239–50. doi:10.1074/jbc.M112.403550. PMC 3476291. PMID 22948142.
Ha BG, Hong JM, Park JY, Ha MH, Kim TH, Cho JY, Ryoo HM, Choi JY, Shin HI, Chun SY, Kim SY, Park EK (juli 2008). "Proteomic profile of osteoclast membrane proteins: identification of Na+/H+ exchanger domain containing 2 and its role in osteoclast fusion". Proteomics. 8 (13): 2625–39. doi:10.1002/pmic.200701192. PMID 18600791. S2CID 5494045.
Huang X, Morse LR, Xu Y, Zahradka J, Sychrová H, Stashenko P, Fan F, Battaglino RA (decembar 2010). "Mutational analysis of NHAoc/NHA2 in Saccharomyces cerevisiae". Biochimica et Biophysica Acta (BBA) - General Subjects. 1800 (12): 1241–7. doi:10.1016/j.bbagen.2010.08.001. PMC 2967667. PMID 20713131.
Fuster DG, Zhang J, Shi M, Bobulescu IA, Andersson S, Moe OW (august 2008). "Characterization of the sodium/hydrogen exchanger NHA2". Journal of the American Society of Nephrology. 19 (8): 1547–56. doi:10.1681/ASN.2007111245. PMC 2488271. PMID 18508966.
Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP (juni 2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Human Molecular Genetics. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
Battaglino RA, Pham L, Morse LR, Vokes M, Sharma A, Odgren PR, Yang M, Sasaki H, Stashenko P (januar 2008). "NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts". Bone. 42 (1): 180–92. doi:10.1016/j.bone.2007.09.046. PMC 3593247. PMID 17988971.
Schushan M, Xiang M, Bogomiakov P, Padan E, Rao R, Ben-Tal N (mart 2010). "Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension". Journal of Molecular Biology. 396 (5): 1181–96. doi:10.1016/j.jmb.2009.12.055. PMC 2824056. PMID 20053353.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164038 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037994 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2".

[UniProt-6] "UniProt, Q86UD5" (jezik: engleski). Pristupljeno 30. 10. 2017.

[7] Xiang M, Feng M, Muend S, Rao R (novembar 2007). "A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension". Proceedings of the National Academy of Sciences of the United States of America. 104 (47): 18677–81. Bibcode:2007PNAS..10418677X. doi:10.1073/pnas.0707120104. PMC 2141836. PMID 18000046.

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