UNC5C

Netrinski receptor UNC5C jest protein koji je kod ljudi kodiran genom UNC5C sa hromosoma 4.

UNC5C
Identifikatori
Aliasi	UNC5C
Vanjski ID-jevi	OMIM: 603610 MGI: 1095412 HomoloGene: 2765 GeneCards: UNC5C
Lokacija gena (čovjek) Hrom. Hromosom 4 (čovjek) Bend 4q22.3 Početak 95,162,504 bp Kraj 95,549,206 bp
Lokacija gena (miš) Hrom. Hromosom 3 (miš) Bend 3 H1|3 65.57 cM Početak 141,170,977 bp Kraj 141,540,685 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • netrin receptor activity • netrin receptor activity involved in chemorepulsion • GO:0001948, GO:0016582 vezivanje za proteine • protein kinase binding • vezivanje tubulina Ćelijska komponenta • integral component of membrane • neuron projection • međućelijske veze • ćelijska membrana • sinapsa • membrana • Akson • dendrit • growth cone • soma • lamellipodium • Filopodija • cell surface • projekcija ćelije Biološki proces • positive regulation of apoptotic process • netrin-activated signaling pathway • multicellular organism development • brain development • regulation of cell migration • GO:0072468 Transdukcija signala • anterior/posterior axon guidance • axon guidance • GO:0097285 apoptoza • negative chemotaxis • chemorepulsion of axon • dorsal root ganglion development Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	8633	22253
Ensembl	ENSG00000182168	ENSMUSG00000059921
UniProt	O95185	O08747
RefSeq (mRNK)	NM_003728	NM_001293561 NM_009472
RefSeq (bjelančevina)	NP_003719	NP_001280490 NP_033498
Lokacija (UCSC)	Chr 4: 95.16 – 95.55 Mb	Chr 3: 141.17 – 141.54 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 931 aminokiselina, а molekulska težina 103.146 Da..

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MRKGLRATAA		RCGLGLGYLL		QMLVLPALAL		LSASGTGSAA		QDDDFFHELP
ETFPSDPPEP		LPHFLIEPEE		AYIVKNKPVN		LYCKASPATQ		IYFKCNSEWV
HQKDHIVDER		VDETSGLIVR		EVSIEISRQQ		VEELFGPEDY		WCQCVAWSSA
GTTKSRKAYV		RIAYLRKTFE		QEPLGKEVSL		EQEVLLQCRP		PEGIPVAEVE
WLKNEDIIDP		VEDRNFYITI		DHNLIIKQAR		LSDTANYTCV		AKNIVAKRKS
TTATVIVYVN		GGWSTWTEWS		VCNSRCGRGY		QKRTRTCTNP		APLNGGAFCE
GQSVQKIACT		TLCPVDGRWT		PWSKWSTCGT		ECTHWRRREC		TAPAPKNGGK
DCDGLVLQSK		NCTDGLCMQT		APDSDDVALY		VGIVIAVIVC		LAISVVVALF
VYRKNHRDFE		SDIIDSSALN		GGFQPVNIKA		ARQDLLAVPP		DLTSAAAMYR
GPVYALHDVS		DKIPMTNSPI		LDPLPNLKIK		VYNTSGAVTP		QDDLSEFTSK
LSPQMTQSLL		ENEALSLKNQ		SLARQTDPSC		TAFGSFNSLG		GHLIVPNSGV
SLLIPAGAIP		QGRVYEMYVT		VHRKETMRPP		MDDSQTLLTP		VVSCGPPGAL
LTRPVVLTMH		HCADPNTEDW		KILLKNQAAQ		GQWEDVVVVG		EENFTTPCYI
QLDAEACHIL		TENLSTYALV		GHSTTKAAAK		RLKLAIFGPL		CCSSLEYSIR
VYCLDDTQDA		LKEILHLERQ		MGGQLLEEPK		ALHFKGSTHN		LRLSIHDIAH
SLWKSKLLAK		YQEIPFYHVW		SGSQRNLHCT		FTLERFSLNT		VELVCKLCVR
QVEGEGQIFQ		LNCTVSEEPT		GIDLPLLDPA		NTITTVTGPS		AFSIPLPIRQ
KLCSSLDAPQ		TRGHDWRMLA		HKLNLDRYLN		YFATKSSPTG		VILDLWEAQN
FPDGNLSMLA		AVLEEMGRHE		TVVSLAAEGQ		Y

Funkcija

Ovaj genski proizvod pripada UNC-5 porodici netrinskih receptora. Netrini su izlučeni proteini koji usmjeravaju proširenje aksona i migraciju ćelija tokom neuralnog razvoja. Oni su bifunkcionalni proteini koji djeluju kao atraktanti za neke tipove ćelioja i kao repelenti za druge, a smatra se da ova suprotna djelovanja posreduju dvije klase receptora. Porodica receptora UNC-5 posreduju u repelentnom odgovoru na netrin; oni su transmembranski proteini koji sadrže dva imunoglobulinska (Ig) domena i dva tipa I trombospondinskih motiva u vanćelijskoj regiji.

Dopunska literatuta

• Kennedy TE (2001). "Cellular mechanisms of netrin function: long-range and short-range actions". Biochem. Cell Biol. 78 (5): 569–75. doi:10.1139/bcb-78-5-569. PMID 11103947.
• Livesey FJ (2001). "Netrins and netrin receptors". Cell. Mol. Life Sci. 56 (1–2): 62–8. doi:10.1007/s000180050006. PMID 11213262. S2CID 33776808.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Thiebault K, Mazelin L, Pays L, et al. (2003). "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4173–8. Bibcode:2003PNAS..100.4173T. doi:10.1073/pnas.0738063100. PMC 153067. PMID 12655055.
• Geisbrecht BV, Dowd KA, Barfield RW, et al. (2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". J. Biol. Chem. 278 (35): 32561–8. doi:10.1074/jbc.M302943200. PMID 12810718.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kruger RP, Lee J, Li W, Guan KL (2005). "Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation". J. Neurosci. 24 (48): 10826–34. doi:10.1523/JNEUROSCI.3715-04.2004. PMC 6730211. PMID 15574733.
• Llambi F, Lourenço FC, Gozuacik D, et al. (2005). "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase". EMBO J. 24 (6): 1192–201. doi:10.1038/sj.emboj.7600584. PMC 556396. PMID 15729359.
• Bernet A, Mazelin L, Coissieux MM, et al. (2008). "Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies". Gastroenterology. 133 (6): 1840–8. doi:10.1053/j.gastro.2007.08.009. PMC 2211510. PMID 17967459.