ZFC3H1

Protein cinkovog prsta sa C3H1 je protein koji je kod ljudi kodiran genom ZFC3H1.

ZFC3H1
Identifikatori
Aliasi	ZFC3H1
Vanjski ID-jevi	MGI: 2446143 HomoloGene: 17017 GeneCards: ZFC3H1
Lokacija gena (čovjek) Hrom. Hromosom 12 (čovjek) Bend 12q21.1 Početak 71,609,599 bp Kraj 71,667,725 bp
Lokacija gena (miš) Hrom. Hromosom 10 (miš) Bend 10|10 D2 Početak 115,220,864 bp Kraj 115,268,677 bp
Ontologija gena Molekularna funkcija • vezivanje iona metala • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje sa RNK Ćelijska komponenta • Vanćelijsko • Egzosomski kompleks • Jedarce • jedro Biološki proces • GO:0033168, GO:0036404, GO:1902360 RNA processing Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	196441	216345
Ensembl	ENSG00000133858	ENSMUSG00000034163
UniProt	O60293	n/a
RefSeq (mRNK)	NM_144982	NM_001033261
RefSeq (bjelančevina)	NP_659419	n/a
Lokacija (UCSC)	Chr 12: 71.61 – 71.67 Mb	Chr 10: 115.22 – 115.27 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Genski lokus ZFC3H1 nalazi se na hromosomu 12, sekvenca q21.1, start: 71,609.599 bp - kraj: 71,667.725 bp.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.989 aminokiselina, a molekulska težina 226.356 Da.

10		20		30		40		50
MATADTPAPA		SSGLSPKEEG		ELEDGEISDD		DNNSQIRSRS		SSSSSGGGLL
PYPRRRPPHS		ARGGGSGGGG		GSSSSSSSSQ		QQLRNFSRSR		HASERGHLRG
PSSYRPKEPF		RSHPPSVRMP		SSSLSESSPR		PSFWERSHLA		LDRFRFRGRP
YRGGSRWSRG		RGVGERGGKP		GCRPPLGGGA		GSGFSSSQSW		REPSPPRKSS
KSFGRSPSRK		QNYSSKNENC		VEETFEDLLL		KYKQIQLELE		CINKDEKLAL
SSKEENVQED		PKTLNFEDQT		STDNVSITKD		SSKEVAPEEK		TQVKTFQAFE
LKPLRQKLTL		PGDKNRLKKV		KDGAKPLSLK		SDTTDSSQGL		QDKEQNLTRR
ISTSDILSEK		KLGEDEEELS		ELQLRLLALQ		SASKKWQQKE		QQVMKESKEK
LTKTKTVQQK		VKTSTKTHSA		KKVSTTAKQA		LRKQQTKAWK		KLQQQKEQER
QKEEDQRKQA		EEEERRKREE		EIRKIRDLSN		QEEQYNRFMK		LVGGKRRSRS
KSSDPDLRRS		LDKQPTDSGG		GIYQYDNYEE		VAMDTDSETS		SPAPSPVQPP
FFSECSLGYF		SPAPSLSLPP		PPQVSSLPPL		SQPYVEGLCV		SLEPLPPLPP
LPPLPPEDPE		QPPKPPFADE		EEEEEMLLRE		ELLKSLANKR		AFKPEETSSN
SDPPSPPVLN		NSHPVPRSNL		SIVSINTVSQ		PRIQNPKFHR		GPRLPRTVIS
LPKHKSVVVT		LNDSDDSESD		GEASKSTNSV		FGGLESMIKE		ARRTAEQASK
PKVPPKSEKE		NDPLRTPEAL		PEEKKIEYRL		LKEEIANREK		QRLIKSDQLK
TSSSSPANSD		VEIDGIGRIA		MVTKQVTDAE		SKLKKHRILL		MKDESVLKNL
VQQEAKKKES		VRNAEAKITK		LTEQLQATEK		ILNVNRMFLK		KLQEQIHRVQ
QRVTIKKALT		LKYGEELARA		KAVASKEIGK		RKLEQDRFGP		NKMMRLDSSP
VSSPRKHSAE		LIAMEKRRLQ		KLEYEYALKI		QKLKEARALK		AKEQQNISPV
VEEEPEFSLP		QPSLHDLTQD		KLTLDTEEND		VDDEILSGSS		RERRRSFLES
NYFTKPNLKH		TDTANKECIN		KLNKNTVEKP		ELFLGLKIGE		LQKLYSKADS
LKQLILKTTT		GITEKVLHGQ		EISVDVDFVT		AQSKTMEVKP		CPFRPYHSPL
LVFKSYRFSP		YYRTKEKLPL		SSVSYSNMIE		PDQCFCRFDL		TGTCNDDDCQ
WQHIQDYTLS		RKQLFQDILS		YNLSLIGCAE		TSTNEEITAS		AEKYVEKLFG
VNKDRMSMDQ		MAVLLVSNIN		ESKGHTPPFT		TYKDKRKWKP		KFWRKPISDN
SFSSDEEQST		GPIKYAFQPE		NQINVPALDT		VVTPDDVRYF		TNETDDIANL
EASVLENPSH		VQLWLKLAYK		YLNQNEGECS		ESLDSALNVL		ARALENNKDN
PEIWCHYLRL		FSKRGTKDEV		QEMCETAVEY		APDYQSFWTF		LHLESTFEEK
DYVCERMLEF		LMGAAKQETS		NILSFQLLEA		LLFRVQLHIF		TGRCQSALAI
LQNALKSAND		GIVAEYLKTS		DRCLAWLAYI		HLIEFNILPS		KFYDPSNDNP
SRIVNTESFV		MPWQAVQDVK		TNPDMLLAVF		EDAVKACTDE		SLAVEERIEA
CLPLYTNMIA		LHQLLERYEA		AMELCKSLLE		SCPINCQLLE		ALVALYLQTN
QHDKARAVWL		TAFEKNPQNA		EVFYHMCKFF		ILQNRGDNLL		PFLRKFIASF
FKPGFEKYNN		LDLFRYLLNI		PGPIDIPSRL		CKGNFDDDMF		NHQVPYLWLI
YCLCHPLQSS		IKETVEAYEA		ALGVAMRCDI		VQKIWMDYLV		FANNRAAGSR
NKVQEFKFFT		DLVNRCLVTV		PARYPIPFSS		ADYWSNYEFH		NRVIFFYLSC
VPKTQHSKTL		ERFCSVMPAN		SGLALRLLQH		EWEESNVQIL		KLQAKMFTYN
IPTCLATWKI		AIAAEIVLKG		QREVHRLYQR		ALQKLPLCAS		LWKDQLLFEA
SEGGKTDNLR		KLVSKCQEIG		VSLNELLNLN		SNKTESKNH

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Dopunska literatura

• Tomita T, Ieguchi K, Coin F, Coin F, Kato Y, Kikuchi H, Oshima Y, Kurata S, Maru Y (2014). "ZFC3H1, a zinc finger protein, modulates IL-8 transcription by binding with celastramycin A, a potential immune suppressor". PLOS ONE. 9 (9): e108957. doi:10.1371/journal.pone.0108957. PMC 4182580. PMID 25268596.