JFIFVBBA - Molecular Cell Research, Accepted manuscript. doi:10.1016/j.bbamcr.2018.07.020*Photoshop 3.08BIM%x|$1C8BIM: printOutputPstSboolInteenumInteClrmprintSixteenBitbool printerNameTEXTprintProofSetupObjc Proof Setup proofSetupBltnenum builtinProof proofCMYK8BIM;-printOutputOptionsCptnboolClbrboolRgsMboolCrnCboolCntCboolLblsboolNgtvboolEmlDboolIntrboolBckgObjcRGBCRd doub@oGrn doub@oBl doub@oBrdTUntF#RltBld UntF#RltRsltUntF#Pxl@ vectorDataboolPgPsenumPgPsPgPCLeftUntF#RltTop UntF#RltScl UntF#Prc@YcropWhenPrintingboolcropRectBottomlong cropRectLeftlong cropRectRightlong cropRectToplong8BIM8BIM&?8BIM Z8BIM8BIM 8BIM 8BIM' 8BIMH/fflff/ff2Z5-8BIMp8BIM@@8BIM8BIM5hhnullboundsObjcRct1Top longLeftlongBtomlongRghtlonghslicesVlLsObjcslicesliceIDlonggroupIDlongoriginenum ESliceOrigin autoGeneratedTypeenum ESliceTypeImg boundsObjcRct1Top longLeftlongBtomlongRghtlonghurlTEXTnullTEXTMsgeTEXTaltTagTEXTcellTextIsHTMLboolcellTextTEXT horzAlignenumESliceHorzAligndefault vertAlignenumESliceVertAligndefault bgColorTypeenumESliceBGColorTypeNone topOutsetlong leftOutsetlong bottomOutsetlong rightOutsetlong8BIM( ?8BIM8BIM p/X T Adobe_CMAdobed            /" ?   3!1AQa"q2B#$Rb34rC%Scs5&DTdE£t6UeuF'Vfv7GWgw5!1AQaq"2B#R3$brCScs4%&5DTdEU6teuFVfv'7GWgw ?GJd^mlKߩ" wgKս Fn&s1kïf]k :i)Tұ~՘Yp`\Khk_U/J^k]O{^!޿QZa"h\ogu^w4*_z>^c&1o]ի{?ѥ=.Q/]/?ʯn=x,Gsim~ (?Ӿa1pݶ_m9_kpSks`N X mj_R+m 5{lj'QoGPh"WfE۵޻2oQ5V]}k k^bJi}WԸ pvݎ߱nʽ;}zסjev?ȧz]oOuKw>ֆF]c~^[GOX?CVzޕA?ѤDdQl7 mY~f!@gK%׍Mvl>GR!חEՆ >9?qo[#L8gi7Q}/O~Oo$:/I19Aq?.QQR3Ec't _ZmA=V)ETWeSY?v[ߙfmi);ܳJ,ePC82Zlp>͹6=/_OOOZeySL?",KjR)ֺML`SuOszgS!0mZ沺ŗnqq .kWKDr(>i}[9i81zGhΟo5DKDr(u>E=vF; -[YgOz-Ʀ:׶c+SbWceYAgSKz1z{RSpFNmxvknu9fCZ9G=ZN[~t|h4l>?[F?oZ )x_"]NWM:V 1} .}g?3i>Plu}NoOsv$[|2l+ة?+:X>jhM3cɻI{=rvP~k}/TYPqzzپWKoEÛm~Ⱥieߢ7W7֯۵%/G\mXrٚl t=ކ 6~>ǽĊۏ~-zXqM}0 Ac2+߷{*]yT~fcGG5`}]c=vQ"JAOksrqM4cȸ`v4ul'eJU*63k UOV5r)̿0C,J=/c?54r\ >~lcC7bηg]7]I}YĻ'վBYӋnt}})Wk׵C8Hݵ=;)?>Y{29վ:6[Xuu\ߤЯԫzo_ȧ+_ZI6j-߷йO>ZHf߫==}22xn7T~bߒmVLƗl|m]"I)uQ~c` v55k1Jf59o7YM! iʖI)ҮV=X1UM /Y7^ƫ?}Mw[L̬Vluw3{_\+)#[r0~c!:F6am}ctq,޾-~7KҍZYO^$cVN}>~nVis?>r?3zRSVf}J_r?3zRSu?җ\ޔW=G b~{m snfYUw3ޗcHʾ6JWe5mtW?ju?ҡwT{tܿI"@Go%-W}t4n3.eQss_UՌ?yuJw]ɪƇ7w[C*k}KOS?J շ87|ȩۜ,H;;2:}hֿ uԴCqY_XkmW׳=bK;YS)~ϺINK;GVf}J_oϺINS*?r?3zU^2.ddPymv퓓߳eLRS8BIM!SAdobe PhotoshopAdobe Photoshop CC XICC_PROFILE HLinomntrRGB XYZ  1acspMSFTIEC sRGB-HP cprtP3desclwtptbkptrXYZgXYZ,bXYZ@dmndTpdmddvuedLview$lumimeas $tech0 rTRC< gTRC< bTRC< textCopyright (c) 1998 Hewlett-Packard CompanydescsRGB IEC61966-2.1sRGB IEC61966-2.1XYZ QXYZ XYZ o8XYZ bXYZ $descIEC http://www.iec.chIEC http://www.iec.chdesc.IEC 61966-2.1 Default RGB colour space - sRGB.IEC 61966-2.1 Default RGB colour space - sRGBdesc,Reference Viewing Condition in IEC61966-2.1,Reference Viewing Condition in IEC61966-2.1view_. \XYZ L VPWmeassig CRT curv #(-27;@EJOTY^chmrw| %+28>ELRY`gnu| &/8AKT]gqz !-8COZfr~ -;HUcq~ +:IXgw'7HYj{+=Oat 2FZn  % : O d y  ' = T j " 9 Q i  * C \ u & @ Z t .Id %A^z &Ca~1Om&Ed#Cc'Ij4Vx&IlAe@e Ek*Qw;c*R{Gp@j>i  A l !!H!u!!!"'"U"""# #8#f###$$M$|$$% %8%h%%%&'&W&&&''I'z''( (?(q(())8)k))**5*h**++6+i++,,9,n,,- -A-v--..L.../$/Z///050l0011J1112*2c223 3F3334+4e4455M555676r667$7`7788P8899B999:6:t::;-;k;;<' >`>>?!?a??@#@d@@A)AjAAB0BrBBC:C}CDDGDDEEUEEF"FgFFG5G{GHHKHHIIcIIJ7J}JK KSKKL*LrLMMJMMN%NnNOOIOOP'PqPQQPQQR1R|RSS_SSTBTTU(UuUVV\VVWDWWX/X}XYYiYZZVZZ[E[[\5\\]']x]^^l^__a_``W``aOaabIbbcCccd@dde=eef=ffg=ggh?hhiCiijHjjkOkklWlmm`mnnknooxop+ppq:qqrKrss]sttptu(uuv>vvwVwxxnxy*yyzFz{{c{|!||}A}~~b~#G k͂0WGrׇ;iΉ3dʋ0cʍ1fΏ6n֑?zM _ɖ4 uL$h՛BdҞ@iءG&vVǥ8nRĩ7u\ЭD-u`ֲK³8%yhYѹJº;.! zpg_XQKFAǿ=ȼ:ɹ8ʷ6˶5̵5͵6ζ7ϸ9к<Ѿ?DINU\dlvۀ܊ݖޢ)߯6DScs 2F[p(@Xr4Pm8Ww)KmAhttp://ns.adobe.com/xap/1.0/ image/tiff doi:10.1016/j.bbamcr.2018.07.020 _targeting Bcl-2-IP3 receptor interaction to treat cancer: A novel approach inspired by nearly a century treating cancer with adrenal corticosteroid hormones Clark W. Distelhorst Bcl-2 Inositol 1,4,5-trisphosphate receptor (IP3R) Calcium (Ca2+) Endoplasmic reticulum Apoptosis Adrenal corticosteroid hormones Dexamethasone Prednisone BBA - Molecular Cell Research, Accepted manuscript. doi:10.1016/j.bbamcr.2018.07.020 Elsevier B.V. journal BBA - Molecular Cell Research Copyright (c) 2018 Elsevier B.V. All rights reserved 0167-4889 10.1016/j.bbamcr.2018.07.020 http://dx.doi.org/10.1016/j.bbamcr.2018.07.020 6.4 10.1016/j.bbamcr.2018.07.020 Elsevier 2018-08-03T20:02:50-07:00 2018-11-06T21:07:48+05:30 2018-11-06T21:07:48+05:30 True Acrobat Distiller 4.05 for Windows converted from application/pdf to application/vnd.adobe.photoshop derived converted from application/vnd.adobe.photoshop to image/tiff saved xmp.iid:5213a165-5f22-2949-b322-0047b2ad12d1 2018-11-06T21:07:48+05:30 Adobe Photoshop CC (Windows) / xmp.did:5213a165-5f22-2949-b322-0047b2ad12d1 xmp.iid:5213a165-5f22-2949-b322-0047b2ad12d1 xmp.did:5213a165-5f22-2949-b322-0047b2ad12d1 3 sRGB IEC61966-2.1 CC       !1A QaqXY"#&67GVW%')3:Fw$(*29BEHRfguv45CIUc8DSsbxert R !1AQaq"R2B#br$34STU%56CGWctu ?z 楒Lr\/]Ar)j^VFR$!ׯ7\U y!1t9t"r/B勣 gOn\kg}|1aeYÈW?F^_Y|}+\sĞ+d,9J3V_#EGNU߫<)!5嗍6ۢ#"\pO_AE}_KLvuW+܋ /ϡG+=[Iyt:?E_ ƋmM-&zf3I huCoS'I9^Zqo"O '_=BS7ۢ#"ܯcVYvW+_B7DW ,k>uQۢ#"\~珌JdB?DvU߫!L?G~l| }\x%0gqkW_aG.\oot5{-r=/-2izG|$n\?C_㫓~d,{>/z?-r=*DOcQ=q*O~_>և\hr% ]u"=_:Zt!ۡ#"\/^{^+l\5CGE_FHX|"q;D:{DU~_䢢S.v"{t:{DUѫ|S[r=*DO|6_3ˈ~\QaevVRpnvRo'E?E_^O4N28wZSNo÷CF"ܟ^ae$sq~߫LJBՑ+NîW~Hq_=LNa߶ӡ~߫/L5+/n\E_rwy}'Wm\,^a;0ܠs}_=C3߹˷AG"?w'_GZJmZOn\~kW+ ^xBIYM}2{t:{DU߫+%2|ס4k_|߫+,/Iq/̱U<6{tZ*nW/| Lڬ돿˅=})pD6۪H~}%U%#+|:9{t:{DuߛرeM9ZO{~UU1xZr:t"\%2\3bxt:q*?,.Y'u=]x7n\E__>FϞϡefCǁr}*7r{I6,{>|l?^ۡ#"ܞG_Zs#CGE__HzĪ#EGE__o[Jp(x3H-r=*yӁ=q۴G_{W+/o?DZeU?C"Rw\n\}} \F_{?$4oDvW(԰wgԒn,7Nk~_įcrX_#CGE_?jN/Lϐ/׍bT\W+_S'o?^}%?zg8VXPvW+\)Y?]qu7/T!]>7#߳V2r8~~=j{>gqm̯ZqGn\hr%dREڏi=-q+]˦-2DUǝۡ#"yޮO0>ק=Z#CGE__S'z|wІr~?~~WٴvuW+_{+%U\vduU۫+ރU^lJ%Vfۢ"rKL5X̎|K2/4s_r=*6|䒢mnskW~WĸB՟BʕW9ƗkW~WĿL5\bӂ{tZq*r%//4N7an\E_rP™|*[56j8K 5#"r%?.)ֽm\n\hr% uN.|7:WxNAY^hlW;t:pЊܭЯ~%&#^#߳fx^k\Al e>z}\akXzmlS.:ԫ1YVDtXJ*<"ʦtP[P}"Lߺ[P"v`i~[~p6G:Gd<<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <<>Q <~f~Oʤ{WsLJqΏו:DA,6ANg,G,TFv|ǥ׾g\~Te*WTtKPڪB׶s FAyҜ#,J0&MU[g'"zlce52{kն>GrKk-\RpVR2tQNΉa}d12$TAi\yq@ @ @ xg&N!\Cp,kQz-jZdJY屡Z;:s9Hr "uqYdP)7pb}+a3b}Ul/>%"BSupdTT(ধHOd#Ti%&3]x3tJd\,̭4LvO,hK1&;~'HLJb <*@`^Y$rYeL H9Ig9I)!dN4\ ,(0( @ ?3N(8$( 2yd,˔g0BY$@a di%]XpO+{NCC=ks2ERZIJN8≜ Y$v=u|"&)(x빌LzlږZN6'ZIה}uUTRU4+.A* QKz8'SxRN))_ԪQZߓ |XRA}kJBu7.C -T$M/*OX6T{;ÜPgHJ RAj %0M4&YD&!~("CK"sD2IM0%'#7&QDv`ȅ2A&PJM"Q,v0瘠6p?"WA2K1J1Ae99I*Ya 6%Zheu$Ry)ɷKc.YQ j9Iih۬-Kt\kCtS"LCFz$SJ` *W#u[D_3#Q(Qfd"@&G @ M>ޢi|M]~P*[Ts+8Fj8Gi,;p odW402NQs>&@ @Wmq}O4OtGEnk8s@ @ >&J\$mnDL/^hR')X“'*_8$`1'郇廣y5KVu{("}f%UҜQKMe<ڦM"Kt4/'uwT倽.I+WmӜ( BSRBY=JKt(ӊ%]qdNyRdIEe=q[C؋uŸT,֍uQP%y9&BlO3yTO4 1O$Muu?2oQ"e5ӈv| w5dߎ%KҶVJq(F0HT34z orL'gqnCfEJBN%Rt]+WLb @[\\_:Nd!6D?,3U9])횩nɹڪ`P$*Ud"i)}2a}0̾?5m9m[tfa/3]QXeWUmgt/ʁ(*j#?+X살}PLꛝ]K:42ΰtӳQYuIn5Lq7cnrH% &a0&~+\%$"ool7؃$O (&3HvW9=Pesp\] .4MNufB i"ZN]XIQGzN]UwήfU*zL,S43S: 8VTdLHܱtf%pj L/qudѣZvRCnu= z}eBȝd Jbz4sETZ9t'$*ޚ‘Kw5mCW _UBS-Ӫ\mXZ7" rzT1E)(S) W&eg +mLeZq2NJvO7QUuR.QNM۳֝+\ YAFaL$+NYBӜA6%1HXFunϝZ#gr,׸hm;S;E^ޱe+Eԧ5kpC;J$IEMJY#ոjLqsvmĉZaqזDfnXrsږwuQ(|l5])*WFvweJ̶q`R*o*ťtM+n]Oފ.RVUIʎEZ/ ʞBr^9'@&-െRiJJЖs t9W+5]Mͨv˞v".&7F5&[w kD]&mt1S ְS;jYO:sjl5"QHHU^SKF(5ct:3kgJؼF6cgTS*WZéu U {x\B<Θ,2J'YupR3/f(C+ZaC0TmEQ&/jyr)J X2(W $)94H8mp+Nw]3\0fY96\܋"?X[387YR>:r/J>;Kj$iy 0ۄۛgNRŕjDYmn^,F5d>1ro:Sz.MR+5t\fr)r7}Iݐ3J`%%-|ٿS%> @ 4JO J;ÇLγKj~iȱ;c|m! @ |v볍Ro j:S܍e^ح:'ҎWR'Mɐ:.djq|#Ћ!#BҮ_+*=T eH78+9I$Brmk8aEf| ?Pc}wUNъPuϙ} nȡJ*uBHLdNB >;.{3hp^nFQԕhNTTCk[e|n)ydi&)'昆YܓL␤aJF~džFn_WZaw;+脴 6VT7JvyW%Җw\EݕoF&t\SIqD-|Y"n}e. n[ɨ{oȼԗ+V*BKֶ(F69o)Fl!*THtpKw #kMY %icF!ku¥t¦=z.ksMwfd'ds0L+O}=I.eR"/Sz9qt뛙4xQnEFRgiKWҬ5z"^E0S4ƶ9K #z*tʚ[/u# &bfԡ5SƼמՉTtim]N%^.sTuMj|OJ.VzR R40[yݒ O.XFPSy{qjɊ:[Z:7Zz[^2*A-&С+2 u)]nTHFa#&ҳ8돌Gh2b<=Ҷ7fO&EE6[MqSԉՄg zƹ`Rb[ +ʕ)Ybff6#bDS҅m$V(m9rC{ 2ԑE!iТ dP]#. piZ4{bṳ.m+s]OLiMM:+z8)L#u"JDjrԝ$i 4<&:Ύh6v.di BmjSB9]TdnUE#ZYQHc -t)R%Nl[3>rY7Kl2KZQTƤ+.hZSR#jWgfNձqg%XI3M!\LO,"Sͦ&YJe𺖓`**eZCG*XioVʝTh'pXj\;ޏƸv#jI6dyԮ-PP"P kZYks4$6jO(#`A?tq=60{a,՛iE@ݒ代U8:V=]&5mH{C!T$%! @ =Hc͚e_U|nȱҒeHƆUS7 PxS5k"qAOR*'-|+qfDLr$>+q)e.Ň=Q{]rЯn.s^@lyW⥼mԧ$Xvtm{2[K"E3Ɂr3ԤW"TZ)T<)ʒ]0 p׍;zcm*4UmaTz]%NjTݐBObJ !E*v-+|i8Je$lX&dxecf*9$*ۓ`p*L S&8g.A߷r#PPaUƬĪVUT5UQyڵc@Y̖g*.F;Hdd d5)LR~LjYyso:focV9;vgrf&5l2z#VdBS3ݒU.IN\ԝɢ@y-ŠdN[neZIb鋄su['_WCWN[;dqyCp_~HSWV? 9pwPK_jG'UL89v+k:4ccذ6w쫱2_%o-Wv7KGL|*T2'VrdG\,AH9FlO)Q:WgazI@S!fH/;q D$\"9I,Q 0 g򋫔 cfvm_iX&%ϭ*n=0hrsjue'E'G([b"}rRM<#*a?̕bTHO L{jF[uqLP)j䟐q^ye f PM$LXM 8 CwWXlBC?-(O-- _Sғ,8@yC2&㼳FYr! v#ߞ @6yOvoevLW҉kt-$6eUP33=Fg kFXq\iU3]|JÊL&'k~'mnjU ^L~V+r}0xB`hW*kV ]23*3va~]ͥp?j]ƃ|Z:2*SV.^"WlO9a,Li)*LY5?䕜 1XY2titI Nw9rcJ1iN)0^"d)nԠN1bay6>KLp:IPZ$ Z*Sި ShT a܂hwKT+[н9k/u8-5a_RVG0 u>sq-ThA**iќ>Ц(uQ2a,\58]䵗"Q5趾+JT4##:ӁEvYDW(;N2+)m%{里r yc/f8ʖEةT 2EjyViC̮UOǔ80LyH펔}HT2\s YۚrZj }i:$ޤBM/ :]Gd_]L&=ǦȊKZfUՖ13BB(FZ7"O*ʠv' 8v'ml/=U+VnZ }J;mj=^tNIt2Af 5$NyT^HC~>%Q\53;j-S=Ȝ'KV7v t+51!H VbӜD&Boc'èFP}GV,8Clpmoo/wǐKy [>9v S\zv?Sd^)JdV8~iZTxĸig35|tѧRf.ه3%*֏-W2t] t(c3f%_,o+тS@KR''R I*}pڭ%w~t[ufUUʣ+gF\rWIdFBA` @sU:KYHZ$~DNa6ɚi&@v@`yce} wYۍs(X*~\ؘ HhDf="'唩\LIϨR8UaGORRWUnfpԦ.RSmf2a N؍4K-ʪ@goPJ 9 !A+,-_ ;줫k%ŸaoU *zja2T˛H$d-Lʼn$L)ܾ:hS%,EKXU/+K0݊ޢߩ6ecf@{rO;iR,Ͳ_uqD y.vNɥ%U"OM'(&d@a ueͰ @ @N4?Q4M]ͼ}W5yyבj:F,?){'x՜5_T[܍Ø).Zu7Na ꪜDG+|ڧ#g+Ҡ)5yH" Y?ՇJET(jDAvkx+0cvZKm4(PzPG1C܎ӂqh@E"n q ۙ+>܅vB]%m9OE=ӍZAؾ'%j.mruM7\B3dI4RQ3y1g2a Շ1G- \-5 %[9>HХ!f,Sk_c=47]ĸ+(3ĥ-^cWU]OL3&QRJNE$\c sI6VK)Y>xQHtN2` 4nU̮..ٌB}Mv&݇:2x&SyVT*lEES (IRq2M1+OD+фJ>BvʘM""0p2)mM3]4IA:[:)=\+tu5R'u/SUu״suOK9!昐dxQSi+*SV_u9uJ[mLYv3,6O_6f%qg{rQI7y@}35.Xofg\szVi:Y/y JЮ8< uNʥivڦW 嶅u [M8%~ z%W =KpvQ hZY.u%!qkOuS޵Uf3h;U}w+YLS[}E,ZBg$D S#yqbWs˳y%^XfZJՌީ--չ]_hb.\ !ƊteN7cZ[A3;EP:k#W2ܐj|*Lyʌ5jaIn1UXEB)~*ȞP U %=qW YjRq&<{BjfJg,)p XTUTv4Z'[1~Y%=Rt7m@)Xv*q7fP<~lL C~ZZnRoe85ѻW`ح]'[YrVrM*Tq@drs#*(η&a%x.x"]fe'VK(Ź1-QQs 1Sd8de[NejMH)x Nt'\&)w#bީ0TEv~n6 Bj/2w1gqW~r]q(W1<\ N5ζwq=t^a\$Q1jf0 6Ϟ0rN%̷XlRn/x9@ @ YPfiDef w@@D6xo 䨒b}֩K[Q!ܵ%TLD̶srGh_?![^^Lqz(eaj A3"@ePx$ S(Sߜ^YZY49з0k6() T pNrYgKq(.7JI/]5!6ibgS r^J;Q/qF0}r}Y)u n)UɲF$ pNJz4dD4<(:ܢ\ЊN.w:FǔT>W-u}άʥU,D34P< z M!*%m`m7[yR Ce+qK= ٥,mwmd嫙eiR7 VйR!<3(,$ eu@R* Gs YLlMQ}J%Y':_h#v@hpLz2Id i ,T0. R͚+N")ET`\68_gZ?b4nfs&-mQ=肣J^VQjyH"yTYSZWbaڶWp*]g*;1̚T"̯ĺlǕiT#C45I %0f,R0ߎ:E]o㕏XZ8,G,0uNe% 6˖,qS,^k͸P}$*Tߜ CC2t`r15iiݪM)Rxc6ҥÜv.~d5$G^jYzV սb(l㛑 ʚ@Y-R6zܺp51 T?Uu#7u?X/2yPq/ExX-`Uu$' FJ}@ @ vf~OMOۯޅsp}k%wS{*y<{"Zfkj~Sfa "&@ c:{J+3^ԕUOPڪYκ ^ߞ)Rllf~b'>my2XJKJʫ 8ly~%uCIPHQ(93;Ե%>,-9BjhJs[BFu%9Azh݋ji+R^8c%kA31RviL*%n` ma/Z7q be9q2^#ج/=kvkpX5nֵ]fAt]-AE3&kWR1q5YըTQ1 <{o܌gsMު;)%v6Ȕ[5E9/gi.8)edk)7%́J%Mdg8 mxYy_;%ֆfޟ_pZ͢A6SLZiBaҁ "nDܩvܚ~c6KWb9Wkj@3Zg*)~ u_CYRHГcuu~nimU֔յ="d֎t[VT<,g2"M(4g( yxDT@ @ @R2 JT<=:=9NLY,$i iD9DiMvTon#YhneLJ;!"cx0 (Tq]s.qq#JgƎu]. k].P6UDJFf]ctHqLbIXR+'RSyH:ʼ-/z*iEY$lasM$(SΔM^7J݊SnUKYw$\{ZdqIa<VD"ۻF[˭Cҗ+!ZԔ0O$]SFZ0gIaS8*bR#'4;]IU"j zRP$qnh%-ZJLNHXL!\uבxN YCZ:p*o<.X9?o(ԺKL8Dhu[o$u3%:4~*؊jX{1h*(tHRJ2c]|d⣕<6_Wqx@ _jX Ie6KV³~F[u|Ε]3Q8H[瘵I|O:yI3X\f8?eյnv(n\55 SON3|um+}v vVҕ oS75mWVܻJmBW[ _b~YѡNߋp.8}ƭ݀i6?+7'C;7vg?Y/ta]C?pn#%3|շہ=?i ǣ[,^ k+/u6=XawPGN|hͥtY%Ctv%3|շ_a݀ҕ Ûӷ˧_H߰Gg™_q\.O~VsCvg[y,<=[CCs|<)kXc=_h m7xS7"KyDV؏;+6ҕLJѶaL/um+u3|jҽ%\HtGoGFqsBKEEҕ=;L/Q0r=[?+:9:8{C~S7z]6?+pӾ>Nbqш_hhԕ ?뿻zk+9~%_h *~ f}Z%w݁i֕ߠyß f}[]7팯'z!L/wӫacF;ƦoE<O~Vs*o=n3|"e;>[x)*Gn߿{oE=d`}}J?~S7zV¿WVgFRT?FЋ?iF3[m݀ J};yvp (][Y.o݅;+$`}rJn?n f}ƭs݁iR;™_rEOvVƒwm f}ƭz'?* ~Y]"-;݀iYҕ6x7Mշ_b; >lvVNa[npljW݀!o*VvyşGfڮ_cv;+vЍDJf}Z%-_!4 Xߤh}~/Zi|㸁tvV~ Po%3|շ#x)P?xS75m+}u`:}}J=;0oܑk%vۀ`:};+yQѿ=S7"L.{vCu`}?+=Fپߏ^-L$Wq?+z>>Cg?Q1g/^POv?+?o=_nyb;>[%CsӾ{ 7v7.݁ivVJ4>v73|յ| ̞O~VqڒvsE9}Zn7t~Vx)P<߿o^1)俨û#CwL%M[Kcq_h;w™_qo%_}tZ?JT0~HS7z[y,S݀" BT?8p7|ЦoEn$z>gJH8E/jҽ.oА4C+:8%C?n/bتͧrw`:}szenzR6S7D;_j݀iZ>*Jߛn;™_rWC~[Ц_rEN/WVmeo݄Y[ O_;>YR˽maL/Y/՟݀ޡXi*ɿq f}ZOYJT?FЦoEᗉ=@>YD>ng7Wf=XAc|`w™_rE𣘌 O~V~ P™_qס{?o/ms™_q5Uvv;+|BT7ߧ f}V &?<OpP?῀|_~j&;6ue`T0\=YY_b;->Y%C~z!L+D=+SxO!3|-b:Q_=_h'Cu3|-egCovV75%Cv{9^oHtlvV P<8o߼;B\kՁi #ҡ?~o f}VW tGgIP~B_rx/$z >?JT>Xx1m~UV r(ehș1gmB _}FY,jgͧ-nr qYH^hԕB^do~BqdiR+%+E*L.S2Y P իAgnrk&{܋K[i:0U.yl;uFt %IzJ}:tBsEaK+meXwX[Ѭfߏ;-4oV[wlʻGqÅm.weo i'eYEp^QŅeYwv[kh@+MuI`;,/YeFpqapYo˲?/ 58mvYeEa@k>=q,xYﯘ8e_sߣOֵ\GqÅ,o{k>w8]?,|%HX\?e~.ei$wX]/[ߣO>2pao,eF$OqÅ,M6n^0..ceYx~we[NZk;.Ce\vvW9ift'eYt`[O@ֳ{,-4% Ye;+3ֵ'eY}O$ GqŅ,-趁 w8[l ߟv[A֋^7o|.v[w4t|qˬqÅ6YgE@8?,]cO20"\#eYo˲tw^ Yeͷv[ӧo<_VOqŅ,v[ix@Kƻ댁8p,]gqD]phseYqߣH]W.@8\?e_sY^QÅ, 7Z~Co]Y~ I~370NfX吖9ɌEg93 >fq@@@y %gZTjXZ%{XAjM݊Q 1JvSG_βQed %dvՓM\̶fuĔn7u붡~kKɍxWiޒBg{F𸱦݂VFs3!2NIצ,)#޵@; ?o_%/?8t@撹oosZ~]zE|PƺGooZh?⇓:?:k8U?/Wj"'eek7aU26<L!]cvO}sW.޵~]q7 W'_}Svm @?D=GokZh!o8F.ɉ[~Dֳ*ޯo! MroZhߟnoSχ˵յ=ߊϦ \GokZ?Wr9?[[CV]nS~5ֶR4*4/^4=w,i akmnmۂ޾U STF EHSO{S.\QW(=ξQgrӏ].C9R"(~h`1nKg۵ohk:.z iXҋ'p2dS*N8_'0k$:kVL]o޽HO߿|vi6gޮvFz/D>,{ݱtz«zϗ$;♉񭟺֯+ \!}Z\cXWr>z {>|Q~ vG?~?'NKLJT޵:\zᷟ-pN6?ndw'~.|>{M/k:t+-zGյA::{TAֳ*?u_sյ'G>k;{zBǛsoX~?S$guK:/~q]kY @r0J"=q F,<"{[\xc`mAWV ˣoUZk\MYUUԹJE27ԢiO٩_$ۀGJ qb^lq.7v4Tg_SPHm OMBaY|xE?okZBˑ/PﷃA)!ֵ{܁_FIjbto:4Hyl|j6ߴ޵?`q_kyOSUr;{ztUr=/_nֵ0mo}O<|{UaM܌͏F:Dvᶅw#~p=vյgG˹o޵0 [+yçk6>)"pϋݴ޵\n/_?w~|݌-./浞Um뗤>{BJFrr vGGoAji(=q(ooZhto׿t~0qf|jaU{ㆫ5:?Yֳ+t^>{ȑl|[>뷭gWr:?/PkȰaj^y_#gUr>zz9xe[͕}U}6aW܎헧~>xj몚*x_~ÏosZhtOCȓ֯+뗫>'=EukX;Wq?=]>+{m][YVk_l+͐V=ndͻ ЯOlP5 {[M(وH^2lڳ]ӿ2+M>6M/j|\*SvMZtumRNQ;I` AO-~WӬ0Fa #&K)μ=:-C-ɇz(&m^:Q\ y)OZQޠ;*i:Ԧyf=Pv);-N]ހ$J{hnf_O0U{J6i2*IJLYK!߇}=@ ß~|Pw`|0<<} >b/E^.[5W3ľ-=KPU̠ǐeݤA>Pw=xm}@q87GL;>xx|>G66NHZ(psttZB kW-ViI$LLJK$'ID@fmwyHR4O XzKR"RQY|`G6|mGɼ0l(l(l(1WVeuE]մO0>կ1Q <<>Q <xx|>xx|>xy߿0@iݙ~Q$?cJx;6ГKJ#ޱ\~tX?KW^xY/ڈqm2d缾 6p5!N<<1Uָyz.i-YWInU ql%B%T[0]Ȣ$q-J`r9B4fY&H&O1e0Kw܂KV(5ƽY:Y3)lXY@~kkf.j_zsdD40.Id@rdPIR۱|C= (KԅaT.^O78JrNn~W]rVSZ(̉ mtbW{TWUi<癮V4lҖZY guxW$T=x "@ @ y^NLũ-M\bJf`Yޫ4I%[Bun!otȚr(;y崎1pW#L!>cFiЃ/4{iEpgRQjqj6uR{]G?u`:+6[/eըo|&7;nR>Զ7:m5%|S/%KIg.QR)Rb'.p1O),.zY6LΦ{MT K]W9#ݵAV5RW*uY$JTJAlYb^1]FqmV۪hcKs |=-V1P?^0(J~ŜONRbȩcu73)mw3 鶪Ȍ\*Kq*Dr&F*)'-@jvX:[ utwYN].lLM7%f ;e;CS]B 4&gc+ 92O"NqC{O!v4RNj~sj6Bk[M$I(Դk( vFL/Iՠ:f0YR#D.ffUouyة0Ru6rT5KND[VZV_AP:H$OQ(L9EJRP]ATִxG*6] }¾ҿ2]uIIHܤ%;$] 4ͳWZ&e7GIkErhfa>9+Fawmk2oGJTVKmlCUv8La[;A K(rk.z\쾧GZ)3\59XW]_tUM}8SL5Jk J@ԹS_N>wE"z`y%cOlsqƖu*ޠxj9U5cQ"֔Jt98Rr$%"d Hbɚl̻}mR`dX)c'%wmKJOQ-1WLg5ĩ L6BL^H;Q5r:p*pS1Nev91N̜–LԼS0 'NASLK^@ 5?OM56V.#5+4ӼHRn="ޞB"hN;k䚵sjdTf).xXt(siL8Q^̔Nj[IWQñڞiV"ۍT.BNP &H"B' I!Ar'&I%0iN`@ 8uCƜɜlü15¤*D/ td[.v)k(RSyS$eJ*yjCRNb3xG1Dn+o.Rǎ`Fu=AgQµZnĕc,ͭi0`Yٓ8Lg-t<@ڙRAKOH)6ڲXvmYͫZ˲x -T֓GoEm4=%NͻK.Ż6f݆ '*@Ȁ@ 9)MhiY$Ih%֮:[4.J5*\ZH5Yʙ8#a?`tno@s0RkoZ9M-Nn%uUSVd=2eZ ,MJmQ!2Y>sYK~;6]Wh @ @ Z;qrC圴w{XS&'o 赡!ŝlʛt%:IRZ)܁0FӫfddڠVeoԹIk{e8-=Rs" rcK<.:::ma{ܭ%QqD{KlQDw1 @ X Q9с1g:YN*q4>I&6Ieb@!n˵jʵeڳSZfezԪ*݋Vسj˷cW^ʴlYNl*JUTLhЀ8(O(44 !0t <8[EmOi'ƛ.Z_GKe~&YARTB6teN0 #s'9"rkj &k^L%m9Xʋ<8ɶ}>Z5NVۺ24/pz2o]KJoRJةN:yJ,%˫@ ٙM>&~Mݱ/U# =.`v;InoSq*Ȯ1V;e꼦NM9C$ @ @ @ @ -5.lk~ g ,bq鰩"i5:s IPtSkl:m+w?bivޭ6۝^tGe7fΒ?fӵ-;s_]ϵ{5h쯲sj]-лIV46lqj΋,%ZƅYc]ZMw"JɌw̩ލlRDD]_F hYO<ĵI,َ{h]ͺj[m.*; gvc/l}f_ȲMeX-+z{V_cbʱ2ҵs~| @ @ @ @ @_K SWJo hFqҦ* neO(LbB6Hd' !{ۼ;Gn,-Mǧ[zϣWi͋*/r=']=n=Z֋hGѭm?kZKKE{g;Gkz )nڤ&kt2[VF: 3VohS Q҅H`QkEm@taPi=seB>{e:Z%mNO5lVGoCײ?[Ի6QJ2J VjrTN*9: ,fO&y (&Y˞Yjͻ6mj՛VU6jͥ)iy]XgIbΒū6[طeVmشͫ6j՛Ie 4Ϧ4h@ @ ;/V}I{cWs~8eymBtw⳾8;MGu7YtUfɛ}0xB`@ @ @ @ @^j7)qLT9j NC:,;cRIvK䀇(fvb^զqvvg;VE+6{~>{E^١}G1g_KjIiƋEc[KcGbݧq Ϝ`FF5A9:a5oիeڻҠ9G+a:Yýrq8ӡ}ݡ]ۭoh,E٬:8J͔ejUA>d=?%ٻ/iZ Ӵ-5Ϸvî=ݢ5֒qϬZ읶TTZT_S-CʜG:VsOjyJDC-K0 ?ݚ~Ѡ;][زmZfńhSJݤhwk@Kl{ev/iV4/glOkt=Y[exhtZDŶ͟W.ƫy~ HVޚftuz!izmYF$r0*Bs&_wGx>ţuV-Nѣ^ݴ}ܟ%`=Ofzvm+v֡v雷^ңE-ɦnٟ@ @ @ @ @ ]y0qn`mݼTu-g11SmB幙i=:V)S672a*beK9-gZh;Ewopi'C1ޮlӽ]6=v4ujhl~>=؎ҟf읣ImzPڳk[ZowխfEitisOܻe{fE⃨i+f̙ yc{RZ*.i'7쟴է:Nvt˦vtSյ:Dӣ9ᗷ^v^w=>󻷵Z]NgٵVftzdޒ9E:ѧ0J .3.LxQNӚqնFYHYbYG%9Gϔ0*k?;o;^{O`e6i-o5 6ozoۺV;ڷjxwNHv-hmF٭h-3} @ M>Ijy]IKWAW?h+_Ujm!`@ @ ɚ:kL#ƅ5!riq")9b򈹦!ȣ 1r%%-RM2ǒ*p )(Mni;;q6V~mҷ75'"K#Nz̞B*_2yP$rgxsh[}j"WZЙ:DF[UP1$$2A>vC;%je^?e^>j*RQ}@[y?-!JN4'Gh/@} (UMFWU]e lZҊwԴBa#AʥXFi&=@ZvQsxG`>cvo}VY ~w92љ䥞**CuF[ tcjʼnގ))0Hiz,01cM\&ZblRSQRS̹->C䧻2",&uIc.YؽM{j!s=Ĭ !Ȓ)Ta-AHZRVd,$|3qG)w i/-La;Z?KR9 ҙ2Ϧ-f(0NHI(} \>,E᳙CsSC雋O4?NK={$nD8V)S|!4f݋K.ƒśv]mVi4qɢt6֓Chf-Rū ZRP`++ilV<ӵ}I[NJ:|q,52-d@"BT e$$Dx?v;l?xWyFgZJ_U7YsuNԶS*c-.JjDI8]:b&p.'4_ȿޝ{uew9jM^KhXorz,{S2qRX!֙H/杅āRq7/]EikGb̈́*ՔtUuUjZ~x{s9:|NNdop}^WFℬZR?R}*WI;4nd*Ll/f.vXPZ{˛xke(2:=LՌ*$N*wf7WdКɐd(wyD@tV\ȴ5% f[%FwSVjZR 0CB{ѕN⡭Ӏ(Z!ZYx*MPtд'smZqC>Դ2-mg@'9<':ye8  >{xmU븴eI뻁Q6R!K$onH )N8tr$y@]ضWƁ.msRSҵ"5)Z^T)@zs&$T,L8YoPP+=f[=bwk>@Tw<ь$0%R9"!9CrػyR]p)alhWUrMT%(Qx}s8T:I V1t QuwnSu3cB\uI܊aso--5}襶,P\I!.tXin FiZAu|H @ @ @ſ{r&n[mثmqM'LiI}/C؆Jd@IgE([(Si6YgL0p՝ŭkWkYسj27콗Ek_Eٻ>VCjZ͔jwy@ @iߙV|6M/mߗ-!g>{)Q5P~dN?ˆٴpusuLØ8}ht zчԟ"T7p,<T?Hl=nQh!>(ʬOu =ƼN9e)cJ&Mٻ9j=(-j@[z T)e&mR(I4ɣ3Q)eӖir ̤Q4dAb+U]5o2*߲׶zIJj)i~Rfւ}%&g#KgS`xQWKn' wOWڗwC, k9JQ 4ѵaLSI醎|zɾu;>9f ܜ@3HsւIƖ BAs=6iIƧwQw[)_sF ҥ5VVoc?97Roճ4%6$6N[ƅȕ8:oQ,*5M|○y DNۄWr3"3`\'TnK'2 LRTa& &Lܐ$ZViσ\b1쵔VOmL> M-YS"tsΞpry@|˷-hZY7TtJ 5gԒݲc M8E.ls;%dC'!ׄR,fAo245xrieJ0o9Ʃa fHD󤖌>y*%2CIJQ'WGLθZ= :;KַHKH^2_ Lp8{`f\<AS2QH˩NWjN,ojv+\֯BM$Q6闣eXR lU2GwJ˳J ]55emSvfYN֣ M6EukCʩڏRdo&wxXJ'Hcy-eH\2E8wyEQږޗqN޾SLhJaQoIN{bV8̹:S[]Ӹ!I^z 36 Sg;̯O|OzT֎[' !Tw_ J[51ֱAoy=81.ggS8j).>[.QûMN dVu^k [\\Ƕ $kNkft$&~37,LˎE&h77Qp[.)PSRt8y۪e%yvoyGM-=)NwAR IlM.Y̺y:ٷWS!` @/x>5T>S`F\ nǓW%V? ԣ 'e)7ylm^ Nl.4Gc4uԿ_EX>)NU>ՔLRVb}XW/gv!"j%R5-]؊jM%H%5uWG&s_jcR/j˙Fђ;IſV43gvR]0)S*j8H`Ȝ#PU$H,}lo r3Ot-鵴BisrM$ꔄd1D9O̚IS>/{MkJ-0XU ѯ4{T LYzA""jq=?%s(U6G,>D;k*ؕW)".ی'BEN* kBv7،?Iz9ڙeJĄ#Eo*d8{gMzS,sc"Bq4ckL 9Bअъ]\щVqP e[l H6C퀨0rvSn%2DiI0IILkNPO*yL(J,ro꥖o(@ @ @ @ @Nz]>CM(M]o@EvS QT;]Gu"y8m ȸu)m! @ @  ݔ| ThYRzOsmdQ7:sI$. @LA"^ f2ITt>Mtb%tZGKW&i5mJdžU+V-9ټҘa-$ | ֏Cj6o^ck{QTi}lRMUS>19N2C%FRc-KY\>aY-H,JH y ɖiGi$ `L<9@栙 MQQ̔d2^x4ti>T#~6oϹQmPT&腴#VDU6¨D.-d\j~14n=q\dO둡]6섳F֕Ti6W]Ty 7~6vb&"ed2HCs|=d K4;Ny.!;e+X(WSw{!hQwL$W)釕$n} 3@[e7\VUM"j,:WS/Oƹ8>N %RS?q<d{[ 9.XnF5[KF[:o$t[ VP*Rv4_XI6rR(FTš.PrD-YIԽ4ZYL*,,RC~}!sIߛ hEt1/SCt WDbʍ-UHr*"BZc4)؂8y1 m}K=ȝuUEdn oS3\]Q\&q55K4-r6E2kF,S P\aȌ̼~Tqt+ /iU/QS0JS`8HQ$eFCqtt9d}رm)+.q=Ը7hv)5 S X̖Nyu"R2ZmR1:̘ N3 4ӾU۫ifĴ5T)cYnV@+SHyI>M*58!LQٍl-6gvVJ [RQjۋdpXh9 .o %93n&Z|kVꠡްKs5Olz2hzۊhrZtȂF3&'^TUt(p4c5sg]MRqޅ. EW'z*C/xlrfF$%Tju!` ~84Ezkn7ffqNoL9S I7R"׳lz}=k-{JzE'Hֹ,wQ"J|&Hrd $ @ Hh!枫o/0[k;SAk]ki᚝TҨZ8TЬX؝'@[BӮecuS폹isGI 驋;pmuɴ+MQKV +*=$m1BR):;\fXIsYzVsyܛk"H[%H-e+xjT)P$(V*^gcH8JwݨƍY0g)Jw;Q1܊jPbeV{*5"a톸9}7J6i ICi"aëzN[CSHWVF#)v{i k9L|LȹBmn\O9(e0kJ]-q5{M\u__\{N&!CJz~C,0il BS?2j(o0G4,9ČĜ@PyksjIdֺJKsopA(25) Śhצ&JE_exXT-u:+nj{qMy[+Q9'mXaiD֡I@Y&M~As>tM}mcUgfNmS#SbiSƜFk)tXi(I4rUQ ۚ5J2tZl)t⎢{'nS) ArYXp҇&YeP m@ @ @ @ @Nզ^&w>_^]kn}6BǟiPtOvՕ-iT񍦔jz9d0@ @ @6O4v+Ռ(JR[4i,mVF]%d&W#q\[aΔB'\@ Ge+=R^@ӕ-ύat[T&XI9YfZg#{}giv-GlYYv5kkGF)?%wދzitݳwڻk읟J-v-V-j՝.òݽvl{Ɋ,u WrzRWڝץ꤅)gz.$)*zz eSIZa,ӗ Ҍ}{Iiv%Vm;6[=[vZseQ>5OoqRKV-Xݾ{'h>n{6G;>?{GmKV*Nx_MwoAKBToau^s֖C$mI!RIJ7{뱣v'uoRƏDSnVՔh֭Zi*(m{WL}+Zͥ흷;]gvϣQaZ+6]Jt6,kvkܳn՜`;-*>N5[EEITYFz:BO R$R%^ɐdsiwjV;OnZ+6Yصa ڵj׽m{j;8~WjǸݿ;cwo}]Bݞ:l贳skHv˲zO @ <%i6d+V;Sb PҒT Fԏ)3Z)Ao*Tې ,FQ @ @ @ @ ӻ38uV|Jx=-]&1`??]+?I~K;%-/g6vqK5])9Co|$ @ @ @ @ +Ttf)-jp7b\*&ՌۧVlԅgnQ Wm,CG^u;'nI渘ZY7;؅Z;{udvř5nNhiO,)kt]z8vMv4:r) ̴ k$pK:C`,+%WRKf AY 464wͽ.[]ٖXoZ8tgi2͈QޝANoEcމ;whڲߡht-hA}+})YHI%QEI)eT!e$$$\JI$$(Gb$I$PI\#mmۖ۫m"@ @ @ @ @ @ @ 4̱JOO'NE}|EsY+unP=5dH~ ݂s4޾s6`0@ @ @ @ u=*]ۡ^?ʼjWj5]_lkG*qzAQIhu36(wHDqŦ8f2y WtvjAGjN܋u%hJ,\$sP^Ĺ^,5 [QR'PRXL yB i%Q$p'y93˖]0.[So7o=?[ M6u۟\U.TmhPOLqNJEܧ,1=z."xڮ[4):t( XZi)Ӑ)*tr3T$ZJTYp-7Nn._<&ʊf*4Z+AIJy n6+-ZDS5k9%"^kkU$qlkm_v⪺z8=Lm9^yRrO IUvTh-v]e:DΝK2;i)O1+VZS%<ـtZ 6Ktk[I۳س)k[m6TJZ<ػgyv;vۻV]v-vӥV6ƓMjٵkSGbըi']Tɋ5q,UFznU4zM5ũ{% oxl4m^HҮ]Nsҏ{.zk:u[NtzK ZVvҵfUr=wwW]WעZ _cUzIҥVhqkGWQoxK;YEn⁜=`pHʽ֩~-i,ȒKVI3Wl}|wfڷҾ,vVYձfʕfJ[mq@'ݷ^ ->Zش6cC;7; v[n׽-۶+ӧ Ia4s93)TW+҂TCK%^q)KO1df$ch;׻;Nh{?x>Ի:-kitTձb۶U\**:]-I]Gjŋ};doKkWEbi]EoIkݱeִe6TNPh)B<?%.S_/Єrz~ tK!;C\^BUkSA I׉R+}Rq) ֥aLYIdD<34Rndgu5:߭@CU1)wYoC\OêtxC`W;sNw]a(v:`ry$NiL!&҈O$3ODO=|B ; CÈKGCx8PZ{DK_<宅gZg;ѭ[_ LPh)>_Ќ]k?扫k'ɎPe&@/#Zg|A@j&-}$s42ȴVYޤκAd[1,{+I_Qg?;~E>~? ?nbe+ƽ껓ƅ~ꚵ cxpi#D{VD۫^Q'r32ՇG/8iF:Ꟶ@BLB"";z"#7x@x>+1*ub_FS\+[%̘ŎUvTr2OXjDdI',Lm>~3Z5=ƥ4hUuRҭ]t:Z:w%y]:j&3H ;N,I4%6ѓSukLTdֻX4YgK4S.eNkK<Ŝj 1g, Ph e@ @ @ @ ;,v4Gz$_׉UַKu䣴o¬?~LRt}0xB`@ @ @ @iK` S',5&՝5QY[jWGS!P,ƥ%+`HSL`Ԝd0[5JsY W@6q;jf_vH8w,2Yfe+EIIͼLk{t~h57(42_ c?]hmvrlXTm:7C_[gﳳfi{{vLQe7z_G*7 T?tT_KPoPiMm/CI@kajh%4ͤL!,rqa @Dvf!C8ǓKQL,8̺Ґϑ0&v^pwq1ʖwî]u 7`wEE僞<4 |0TFPm2u ?5QѰ@mñk./ʿ|YHܨ]懘?TxG1FfX[ofθ,L:t&K$L"|͸,6_M{=6OWz eѧm¬-f?Y%/ftkZ;+^֕ٳgfջVڲV,V;ȓ.R^d>CGÆ9ڝU'akTJl>}ܲiQ|2UoB퇾 ;?ǿOj0hy1s'N]޳iftcTs''7tFR;p_.7i*~w]{Lwd]-EWūΜE*.if ;˸?m>kV]G՛]v"l6Z!4ݟOkv].MvUnŽ%ҵnÇFTI.iM>:pK4(> l҈6*Wa0Wh},| 8CGwxw~.hb3Y?]}+e<n>ɛvU{NWs w^i =Y .I}":LlXckRZTJsԿjr۫uO5QE7>z}< ,L scrD!:b,a0نsNsLig} ~z?Qm+mCl @ @ @ 4OQSWsoc98KU֮3NQ%ޡ-_My?e__m2d @ @ @ צ^gp1pUPVuFCNA _Sj凘Rrí,\Ȕ$( }-G ǫ9k%mqJuDCuPk!TԄI3ROnY26׳-Kj%_[֥Q3H/Pڰ1B.s;ܬd^t%I`_65}ew+UO/*Vo˓*jmr<ԬvUJq[,R XpSy~(_G,iz-PXRʹnFHSΦCScIaݛK*#7}wػi2=;˧VmXZ]z՛vн r]F89emn%n1[B_@6;:{gm̉Dn H9jT<$<އ{-?G ݅;//ƅgɪ$gyu=`uj\v"OxNhm.OVc02H%(8_+Z7Y}5dE[ΧT*2OsSc *T!Wu˲Q6B[V c*Y,&r̔dtg͜dfY2N ͟zeݳ]}IaY\5%Ÿt. WUm(ĽZ$ƋEi Rr=@Td21뫇WaqNMk]6[kEbںފ+kik|}z[ӲQ35Z46%@J%I[wpm=NtfGJu{QN)ę'it 'g"}p u96jӦn̪`ݚV뒪{ȹ:3u*["奓N1,qa6EQRmE9WɈR!N`L.Zh1"G~Z}{N[8Stj7x={UompFjDlq-rJTs^+ F WZUneؖNTo,0Iti"%A^Pt3"Tn3[)jXѪ9(*BAi5a,l%pW]S@Q[ DEsOW,6=TR& ).A3*Y@o)9@'sm'e2N1w77ܬ^ȍ.hg 2ja* eKFD4R3C:ג\%J"VQS= .nU*oJ.qu\u7 f^glsEOD L6i gҝ5W3@rW2չuPT&;D_^[P-. "r]&z}+F{23ڃԷ޲I V򦭲bcM!0F9Z/$z~=A(TReH*բ(\UNti<rq<9'd_>.ۀ`6mz 芓X|HI)!7`HG^Y謧dP°R/\w¹ֳLkCyGٍw'T`k wqH›̆-,Bw*i#ULj*WQjArfP0'%aY:\8锷(0cD݌ɺ&Iq{AЮԔ[ZvPVVlJY^\Ug<4-r)5bY7tSE XBڄFשZ -MvQAH(AC/ ըM4elׁ0O(髫}8Mb'q7˜MCzXڟ[|.8˦ۮ{WMZ.-0#bڞzp6nn3y, X준.ҽVK̼/㪄UͭWk\Nv)VVT_gL-D $R>*&1 J39BO#ì_^k 8ݶhFw]arM]sj)*PZ槺LMf͍c" vtjS(mpac$Jv0ROׄ˵G;8Na!ǻeYquʸVi>Xl~^4%}8mMhH*R{{2j.Pڝc|j*:)PrAgw- E00iդK\8&gF;X;bo%it쥧5uaRU=yozh2jKr$ %Dy!*¤R>YYmki&*C}O?ا-_fj܆ɩ]42}"rVEMrcl8`8AI,@r"2nt [&JM9#Ύ6QW:[X)Ws hoziƶ2np0){2(sÅ-Kti*3W0ȼzҼU֧SUM*#ꃕ9Z_ b 34zFȒn3(xiSӬŤ˥5H @ @ @ ]> f|w,Qu c LUeekv;Ioo"˿mUsN5ɛ}0x @ @ @ @ xxtSݯ-Ժu]{U&Uu*4DiLRYK*IyEpBQOAO`~{z)Nk30wfdʩjݢDF#U3yn.e"hLi ¾uy]gM/7vFFj=:IUnrؒJQLGD =++`ba>VE{"Ig L)t$vovA,$tYjedW)AUU0ΜOV>ҦIOD$,5Z3KZKvS1ZFon˺yxܞ_\Z )mYj,\gH"e6gQ$Q)J%BM߿wϔ  )jû`r2+tOS[Zِ)L+r!ԘKRI1[I0 G[fuNeWju)[gr)ۨKh8ԔZҕ2(ׅ*)ZZI5H)6xJXbjd2Q٭T2PWBzbtkRRː,9}*gOh9C'f[2 {)r4D%s^X!L,ͭZP6hlO"VI[%/~HNP7$T@DwÞdݭG1Ie>Wطzފz(EUs=/)tlNH[ү) aK -pP1PQUld+rU][ʹʡBoZE<92:uF7yQ ٲ YmXOD4[jGܺt(7^bdž8M,[ c&oSW]:1 f*%[}.|n[`␽UvRze- fnXS*bu o3߱;/ԎӧFZӑHLdԓk[qU`T`3qhp-~ Nt۪xm7P&zf @ @ @ @N4Jͽ7v=q* n\;]Gu"<`o5g.5T6`!0@ @ @ @ @ @ @ @ @ @ @ @ ]>$KWoۿx-վgUlZƜ/FaPxֺ!Z*z{43{D5q4!NѥsJ+ZS~&HCS`MF"]TdqUws7}W؜c5^o7uUw >ơ|V_"VrGuwS}C>w!f} <[Kߍ]ޒe}V_Gv,׏յ1/rp@WzIOy;_oogg);$}^<߬w>^HB! 8[RX)}G~o<>hBx,&2.I/>a O}llvQeGuwEUa ^>RҽKMUB6A= )?Y]ވRoGIO>wh%zٵ\}pUޒ|o&/БiJi=ޒC龁'y{%OI㪰jRH(?>a ^>Vmeͩϭ:$o'xzvsBľoAk&Wϕ (>qm^>յ~[_=ޒe}W/z%Ե}1]i'E,v^>V}=/ԜCS{}O}g_.35}{$/BM[Q>ݫ>YWq]i'|x ^>VLK~ޒ=U֒eܳݼ.S e]'T__vϩyڼ}ۚuuMϪBxRj#Ot}gwA^>Vvqٱ|úKp>kjZ:$;!|K+6}oM7۟oϜa,׏S.''O}g~|sw _7[O5XM,nn?.0ͥ ΄wWZIکY#77˦^>Y6o9^Ouwp}=>瓿_: cO{ϩ/BZ[w?o1]&MSy 5GftyH)>DǪ[[~_8Hxzi%Hմ-l.͛S]&Y_6/|ރV]&;}_^?y_hBn=֒e7}WBxRoH?}7}Wߗļ} k7~us z$ʯxσ_/el˞]&7ݳʷOUdWI}Oy]؃U_A]'Q}}||XYAj~KsoUbq[Y-OE,ϛ~NX_.>aRSQw,׏Էni$/Ͽ/pa _75-my{$oϟ!_g/]'S _7OuwMU^>VoUI=ޒe7}WBյ[}QޒaMGG%XOx8m_;+(@uWzIziyVHBմ'5]֒e7}WBxRn#K{Ϫ 55-_.7֒e7ӈ}|ĹZVUwWzI}Oy~/s~ľoBCM'2KnM,.BauvdWzI}4Oy@?/j\ݕ?UuM7ܳ+Ѕ/B[˃iy/CO+BxRoS}Cg/! ^>UlTUޒe7yʺմUDUi :$ǚ>{.xB5md x]%mNn<Ѕ|U^_vDUuMS_wC\-}uuoDwWzIųa _7"Ӆ ]U)dWzIAˇ~%zV؞㺻L9>!|KjZ_UuM,! ^>ԴRLy=0s/x+O oStuwMSݹ+jښdƗ֒e7yWBU^_ԞI/Ϳ}_7B5-DOuwßU%z K[\eGuw tgoýBķNGuuMS}>o_.4"{$okЎͥs]'Q}=~}\~ewWZIM7yO\_zF 4ޥ;$ob-~W^i%Q}}| _7vZ wWzIzhʿ>| 5]KY:0ŞT*W*SBgnjrFTIE220/ q7!ᶱXʴfw#1<͋>@+2ˇm( 9jT--#D;lW""4U(>RӌhBǰ؅>ֻ`0ZА=cYBxk]Z,{`,!0aw@r0G =x k+^nb0Z'@g }whz؇ֻ⷗ y=c[C.|W0aZ0 k+DAֻ%b0ZЗ`z؅>ֻ@r  k=?xk]/>?ֻIyq4,!Zya=ub0Z?parent.window.postMessage('ixistenz.url:https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce1/6345611/4b1ec8737d92/nihms-1502949-f0003.jpg', '*');
  NODES