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Selpercatinib

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Description
English: Figure 1. The mechanism of pralsetinib, selpercatinib, cabozantinib, and vandetanib inhibiting different receptors and their respective intracellular cascades. Only receptors inhibited by cabozantinib being investigated in the EXAM study are mentioned. RET: Rearranged during transfection. MET: Tyrosine-protein kinase met or hepatocyte growth factor receptor. VEGFR-2: Vascular epithelial growth factor 2. EFGR: Epidermal growth factor receptor. RAS: Rat sarcoma. RAF: Rapidly accelerated fibrosarcoma. MEK: Mitogen-activated protein kinase kinase-1. ERK: Extracellular regulated kinase. MAPK: Mitogen-activated protein kinase. PI3K: Phosphoinositide 3 kinases. AKT: Protein kinase B. mTOR: Mammalian _target of rapamycin. MDM2: Mouse double minute 2. BAD: BCL2 associated agonist of cell death. The figure was created in Miro.
Date
Source https://www.mdpi.com/1422-0067/24/3/2312
Author Højer Wang, L.; Wehland, M.; Wise, P.M.; Infanger, M.; Grimm, D.; Kreissl, M.C.

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current20:35, 14 April 2024Thumbnail for version as of 20:35, 14 April 20241,280 × 928 (490 KB)Ozzie10aaaa (talk | contribs)adjust
20:18, 14 April 2024Thumbnail for version as of 20:18, 14 April 20241,280 × 928 (575 KB)Ozzie10aaaa (talk | contribs)Uploaded a work by Højer Wang, L.; Wehland, M.; Wise, P.M.; Infanger, M.; Grimm, D.; Kreissl, M.C. from https://www.mdpi.com/1422-0067/24/3/2312 with UploadWizard

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